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Alzheimer’s disease (AD) is a progressive neurological disorder that represents a major cause of dementia worldwide. Its pathogenesis involves multiple pathways, including the amyloid cascade, tau protein, oxidative stress, and metal ion dysregulation. Recent studies have suggested a critical link between changes in gut microbial diversity and the disruption of the gut–brain axis in AD. Previous studies primarily explored the potential benefits of probiotics and prebiotics in managing AD. However, studies have yet to fully describe a novel promising approach involving the use of synbiotics, which include a combination of active probiotics and new-generation prebiotics. Synbiotics show potential for mitigating the onset and progression of AD, thereby offering a holistic approach to address the multifaceted nature of AD. This review article primarily aims to gain further insights into the mechanisms of AD, specifically the intricate interaction between gut bacteria and the brain via the gut–brain axis. By understanding this relationship, we can identify potential targets for intervention and therapeutic strategies to combat AD effectively. This review also discusses substantial evidence supporting the role of synbiotics as a promising AD treatment that surpasses traditional probiotic or prebiotic interventions. We find that synbiotics may be used not only to address cognitive decline but also to reduce AD-related psychological burden, thus enhancing the overall quality of life of patients with AD.

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권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Using synbiotics as a therapy to protect mental health in Alzheimer's disease Anh Pham Thi Ngoc, Adil Zahoor, Dong Gyun Kim, Seung Hwan Yang p. 1739-1747

Effects of metal and metal oxide nanoparticles against biofilm-forming bacteria : a systematic review Hend Algadi, Mohammed Abdelfatah Alhoot, Anis Rageh Al-Maleki, Neny Purwitasari p. 1748-1756

Variations in the antivirulence effects of fatty acids and virstatin against Vibrio cholerae strains Donghyun Lee, Jayun Joo, Hunseok Choi, Seonghyeon Son, Jonghyun Bae, Dong Wook Kim, Eun Jin Kim p. 1757-1768

(The) gut microbial lipid metabolite 14(15)-EpETE inhibits substance P release by targeting GCG/PKA signaling to relieve cisplatin-induced nausea and vomiting in rats Man Lu, Liwei Xie, Sijie Yin, Jing Zhou, Lingmei Yi, Ling Ye p. 1769-1777

Antidepressant effect and mechanism of Picea mariana essential oil on reserpine-induced depression model mice Ying Wang, Guofeng Shi, Yixi Zeng, Juting Li, Yongyu Wu, Jiahui Zheng, Anjing Xu, Yanqing Ma, Lanyue Zhang, Hui Li p. 1778-1788

Impact of high-temperature feeds on gut microbiota and MAFLD Lijun Xue, Kaimin Li, Yanfei Jia, Dongxue Yao, Xuexing Guo, Shuhong Zhang p. 1789-1802

Mutagenicity and genotoxicity assessment of Leuconostoc lactis DMLL10 isolated from kimchi Heejung Park, Seoyeon Lee, Sojeong Heo, Do-Won Jeong p. 1803-1809

ICP5249 promotes hair growth by activating the AMPK-autophagy signaling pathway Jung Ok Lee, Yu-jin Kim, You Na Jang, Jung min Lee, Kayoung Shin, Sekyoo Jeong, Hwa-Jee Chung, Beom Joon Kim p. 1810-1818

Mesorhizobium koreense sp. nov., isolated from soil Hyosun Lee, Dhiraj Kumar Chaudhary, Dong-Uk Kim p. 1819-1825

Identification and characterization of an R-M system in Paracoccus denitrifican DYTN-1 to improve the plasmid conjugation transfer efficiency Yunpeng Shi, Wenyan Cao, Zhiping Zheng, Sha Xu, Lijuan Chai, Shenghu Zhou, Yu Deng p. 1826-1835

In silico analysis and biochemical characterization of Streptomyces PET hydrolase with bis(2-hydroxyethyl) terephthalate biodegradation activity Gobinda Thapa, So-Ra Han, Prakash Paudel, Min-Su Kim, Young-Soo Hong, Tae-Jin Oh p. 1836-1847

Developing strain-specific simple sequence repeat (SSR) markers for Chlorella sorokiniana Mais Sweiss, Maen Hasan, Nidal Odat p. 1848-1856

Roles of endophytic fungi isolated from Mangifera indica L. in promoting plant growth Kanyapat Sonsiam, Orlavanh Sonesouphap, Anyaporn Sangkaew, Pariyanuj Chulaka, Prakitsin Sihanonth, Chulee Yompakdee p. 1857-1866

Kraft lignin decomposition by forest soil bacterium Pseudomonas kribbensis CHA-19 Dockyu Kim, Han-Woo Kim, Hyoungseok Lee p. 1867-1875

Novel insights into Cr(Ⅵ)-induced rhamnolipid production and gene expression in Pseudomonas aeruginosa RW9 for potential bioremediation Fatini Mat Arisah, Norhayati Ramli, Hidayah Ariffin, Toshinari Maeda, Mohammed Abdillah Ahmad Farid, Mohd Zulkhairi Mohd Yusoff p. 1877-1889

Analyzing the effect of microbial consortia fermentation on the quality of HnB by untargeted metabolomics Ling Zou, Hong Zhang, Zhonghua Liu, Jianfeng Sun, Yang Hu, Yishu Ding, Xinwei Ji, Zhenfei Yang, Qi Zhang, Binbin Hu p. 1890-1897

Study on optimization of liquid fermentation medium and antitumor activity of the Mycelium on Phyllopora lonicerae Min Liu, Lu Liu, Guoli Zhang, Guangyuan Wang, Ranran Hou, Yinghao Zhang, Xuemei Tian p. 1898-1911

Enhancing protein content in wild-type Saccharomyces cerevisiae via random mutagenesis and optimized fermentation conditions Sang-Hun Do, Tae-Gi Lee, Sun-Ki Kim p. 1912-1918

Sensitive and enzyme-free Pseudomonas aeruginosa detection and isolation via DNAzyme cascade triggered DNA tweezer Furong Liu, Jingyuan Xu, Lihua Yang p. 1919-1925

Engineering of recombinant human papillomavirus 16 L1 protein for incorporation with para-azido-L-phenylalanine Jinhyeon Kim, Ki Jun Jeong, Geun-Joong Kim, Jong-il Choi p. 1926-1932

참고문헌 (86건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Host microbiota constantly control maturation and function of microglia in the CNS 미소장
2 The Role of Tau in Alzheimer's Disease and Related Disorders 미소장
3 Structural and functional features of central nervous system lymphatic vessels 미소장
4 The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. 미소장
5 BDNF serum and CSF concentrations in Alzheimer’s disease, normal pressure hydrocephalus and healthy controls 미소장
6 Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease–like pathology and cognitive decline 미소장
7 IL12 polymorphisms, HBV infection and risk of hepatocellular carcinoma in a high‐risk Chinese population 미소장
8 Psychobiotics: A Novel Class of Psychotropic 미소장
9 Oxidative stress mediates the pathogenic effect of different Alzheimer’s disease risk factors 미소장
10 Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology 미소장
11 Hippocampal neurogenesis as a target for the treatment of mental illness: A critical evaluation 미소장
12 Chronic Neuron-Specific Tumor Necrosis Factor-Alpha Expression Enhances the Local Inflammatory Environment Ultimately Leading to Neuronal Death in 3xTg-AD Mice 미소장
13 Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses 미소장
14 Metal ions, Alzheimer's disease and chelation therapy 미소장
15 The presenilin hypothesis of Alzheimer's disease: Evidence for a loss-of-function pathogenic mechanism 미소장
16 Synaptic plasticity of NMDA receptors: mechanisms and functional implications 미소장
17 Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway 미소장
18 Antidepressant-Like Effects of the Histone Deacetylase Inhibitor, Sodium Butyrate, in the Mouse 미소장
19 The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism 미소장
20 Dietary modulation of the human colonic microbiota: updating the concept of prebiotics 미소장
21 The Serotonin Syndrome 미소장
22 Depression and Risk for Alzheimer Disease 미소장
23 Oxidative Stress and the Pathogenesis of Alzheimer's Disease 미소장
24 CD36 Mediates the Innate Host Response to β-Amyloid 미소장
25 Tau in Alzheimer Disease and Related Tauopathies 미소장
26 ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease 미소장
27 Oxidative stress precedes fibrillar deposition of Alzheimer's disease amyloid β-peptide (1–42) in a transgenic Caenorhabditis elegans model 미소장
28 The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age‐Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults 미소장
29 Psychiatric disorders associated with Alzheimer's disease 미소장
30 The amyloid hypothesis of Alzheimer's disease at 25 years 미소장
31 Novel osmotin inhibits SREBP2 via the AdipoR1/AMPK/SIRT1 pathway to improve Alzheimer’s disease neuropathological deficits 미소장
32 Inflammatory Cytokines and Alzheimer’s Disease: A Review from the Perspective of Genetic Polymorphisms 미소장
33 The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease: A Mini Review 미소장
34 Minocycline reduces inflammatory parameters in the brain structures and serum and reverses memory impairment caused by the administration of amyloid β (1-42) in mice 미소장
35 Diagnostic Biomarkers of Alzheimer’s Disease as Identified in Saliva using 1H NMR-Based Metabolomics 미소장
36 The vicious circle of hypometabolism in neurodegenerative diseases: Ways and mechanisms of metabolic correction 미소장
37 Microbiota modulation counteracts Alzheimer’s disease progression influencing neuronal proteolysis and gut hormones plasma levels 미소장
38 The Enteric Network: Interactions between the Immune and Nervous Systems of the Gut 미소장
39 Bacterial Probiotics their Importances and Limitations: A Review 미소장
40 Therapeutic potential of Bifidobacterium breve strain A1 for preventing cognitive impairment in Alzheimer’s disease 미소장
41 Protective roles of intestinal microbiota derived short chain fatty acids in Alzheimer’s disease-type beta-amyloid neuropathological mechanisms 미소장
42 Prebiotic Effect of Fructooligosaccharides from Morinda officinalis on Alzheimer’s Disease in Rodent Models by Targeting the Microbiota-Gut-Brain Axis 미소장
43 Decreased microglial activation through gut-brain axis by prebiotics, probiotics, or synbiotics effectively restored cognitive function in obese-insulin resistant rats 미소장
44 Nutritional patterns associated with the maintenance of neurocognitive functions and the risk of dementia and Alzheimer’s disease: A focus on human studies 미소장
45 A novel polyphenolic prebiotic and probiotic formulation have synergistic effects on the gut microbiota influencing Drosophila melanogaster physiology 미소장
46 The Brain-Gut-Microbiome Axis 미소장
47 Gut microbes as future therapeutics in treating inflammatory and infectious diseases: Lessons from recent findings 미소장
48 Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features 미소장
49 Probiotic and selenium co-supplementation, and the effects on clinical, metabolic and genetic status in Alzheimer's disease: A randomized, double-blind, controlled trial 미소장
50 Amyloid-β pathology enhances pathological fibrillary tau seeding induced by Alzheimer PHF in vivo 미소장
51 Psychobiotics in mental health, neurodegenerative and neurodevelopmental disorders 미소장
52 Small molecules as therapeutic drugs for Alzheimer's disease 미소장
53 Crosstalk between Oxidative Stress and Tauopathy 미소장
54 A novel synbiotic delays Alzheimer’s disease onset via combinatorial gut-brain-axis signaling in Drosophila melanogaster 미소장
55 The pros, cons, and many unknowns of probiotics 미소장
56 Effects of Bifidobacterium breve A1 on the cognitive function of older adults with memory complaints: a randomised, double-blind, placebo-controlled trial 미소장
57 Effect of synbiotic and probiotic supplementation on serum brain-derived neurotrophic factor level, depression and anxiety symptoms in hemodialysis patients: a randomized, double-blinded, clinical trial 미소장
58 Role of the Immune System in the Development of the Central Nervous System 미소장
59 New Insights Into the Pathogenesis of Alzheimer's Disease 미소장
60 Sodium Butyrate Reduces Brain Amyloid-β Levels and Improves Cognitive Memory Performance in an Alzheimer’s Disease Transgenic Mouse Model at an Early Disease Stage 미소장
61 Oxidative Stress and Dementia in Alzheimer’s Patients: Effects of Synbiotic Supplementation 미소장
62 Protective effect of sodium propionate in Aβ1-42 -induced neurotoxicity and spinal cord trauma 미소장
63 B cells migrate into remote brain areas and support neurogenesis and functional recovery after focal stroke in mice 미소장
64 The Bewildering Effect of AMPK Activators in Alzheimer’s Disease: Review of the Current Evidence 미소장
65 Metabolomics and incident dementia in older Chinese adults: The Shanghai Aging Study 미소장
66 Potentiation of anti-Alzheimer activity of curcumin by probiotic Lactobacillus rhamnosus UBLR-58 against scopolamine-induced memory impairment in mice 미소장
67 Synbiotic-Derived Metabolites Reduce Neuroinflammatory Symptoms of Alzheimer’s Disease 미소장
68 Clinical Trials of Probiotic Strains in Selected Disease Entities 미소장
69 Prebiotics Regulation of Intestinal Microbiota Attenuates Cognitive Dysfunction Induced by Surgery Stimulation in APP/PS1 Mice 미소장
70 Tau Protein and Its Role in Blood–Brain Barrier Dysfunction 미소장
71 The gut microbiota–brain axis in behaviour and brain disorders 미소장
72 G82S RAGE polymorphism influences amyloid-RAGE interactions relevant in Alzheimer’s disease pathology 미소장
73 The Microbiome and Alzheimer’s Disease: Potential and Limitations of Prebiotic, Synbiotic, and Probiotic Formulations 미소장
74 The Effect of Synbiotic and Probiotic Supplementation on Mental Health Parameters in Patients Undergoing Hemodialysis: A Double-blind, Randomized, Placebo-controlled Trial 미소장
75 Lactobacillus plantarum 69-2 Combined with Galacto-Oligosaccharides Alleviates d-Galactose-Induced Aging by Regulating the AMPK/SIRT1 Signaling Pathway and Gut Microbiota in Mice 미소장
76 Prebiotic Lactulose Ameliorates the Cognitive Deficit in Alzheimer’s Disease Mouse Model through Macroautophagy and Chaperone-Mediated Autophagy Pathways 미소장
77 Alzheimer’s disease and its treatment by different approaches: A review 미소장
78 The Relationship Between Anxiety and Alzheimer’s Disease1 미소장
79 Gut microbiota in mental health and depression: role of pre/pro/synbiotics in their modulation 미소장
80 Cholinergic System and Its Therapeutic Importance in Inflammation and Autoimmunity 미소장
81 Nutraceuticals-based therapeutic approach: recent advances to combat pathogenesis of Alzheimer’s disease 미소장
82 Serum BDNF as a Potential Biomarker of Alzheimer's Disease: Verification Through Assessment of Serum, Cerebrospinal Fluid, and Medial Temporal Lobe Atrophy 미소장
83 Blood-Brain Barrier Dysfunction in CNS Disorders and Putative Therapeutic Targets: An Overview 미소장
84 The beneficial effect of synbiotics consumption on Alzheimer's disease mouse model via reducing local and systemic inflammation 미소장
85 Alzheimer disease 미소장
86 Therapeutic potential of natural molecules against Alzheimer's disease via SIRT1 modulation 미소장

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