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요약문 3
I. 서론 11
1. 연구 배경 11
2. 연구 목적 12
II. 연구 내용 및 방법 13
1. 연구 내용 13
2. 연구 방법 15
III. 연구 결과 19
1. AAALAC-I 인증 프로세스 흐름도 19
2. 연구 결과 21
IV. 결론 35
참고문헌 36
Abstract 37
[부록 1] PD 및 부록 40
Section 1. Introduction 45
Section 2. Description 50
I. Animal Care and Use Program 50
A. Program Management 50
1. Program Management Responsibility 50
a. The Institutional Official 50
b. The Attending Veterinarian 50
c. Collaborations 51
2. Personnel Management 51
a. Training and Education 51
i. Veterinary and Other Professional Staff 51
ii. Animal Care Personnel 52
iii. The Research Team 52
b. Occupational Health and Safety of Personnel 54
i. Hazard Identification and Risk Assessment 55
ii. Facilities, Equipment and Monitoring 56
iii. Personnel Training 58
iv. Personal Hygiene 59
v. Animal Experimentation Involving Hazards 59
vi. Personal Protection 61
vii. Medical Evaluation and Preventive Medicine for Personnel 62
c. Investigating and Reporting Animal Welfare Concerns 63
B. Program Oversight 64
1. The Role of the IACUC/OB 64
a. IACUC/OB Composition and Function 64
b. Protocol Review 64
c. Special Considerations for IACUC/OB Review 66
i. Experimental and Humane Endpoints 66
ii. Unexpected Outcomes that Affect Animal Well-being 66
iii. Physical Restraint 66
iv. Multiple Survival Surgical Procedures 67
v. Food and Fluid Regulation 67
vi. Use of Non-Pharmaceutical-Grade Drugs and Other Substances 68
vii. Field Investigations 68
viii. Agricultural Animals 68
ix. Animal Reuse 68
2. Post-Approval Monitoring 69
II. Animal Environment, Housing and Management 69
A. Animal Environment 69
1. Temperature and Humidity 69
2. Ventilation and Air Quality 70
3. Life Support Systems for Aquatic Species 70
4. Noise and Vibration 70
B. Animal Housing(All terrestrial, flighted, and aquatic species) 71
1. Primary Enclosures 71
2. Environmental Enrichment, Social and Behavioral Management 71
a. Enrichment 71
b. Social Environment 72
c. Procedural Habituation and Training of Animals 72
d. Enrichment, Social and Behavioral Management Program Review 72
e. Sheltered or Outdoor Housing 72
f. Naturalistic Environments 73
C. Animal Facility Management 73
1. Husbandry 73
a. Food 73
b. Drinking Water 74
c. Bedding and Nesting Materials 75
d. Miscellaneous Animal Care and Use Equipment 75
e. Sanitation 76
f. Waste Disposal 77
g. Pest Control 77
h. Emergency, Weekend and Holiday Care 78
2. Population Management 79
a. Identification 79
b. Record Keeping 79
c. Breeding, Genetics and Nomenclature 79
III. Veterinary Care 79
A. Animal Procurement and Transportation 80
1. Animal Procurement 80
2. Transportation of Animals 80
B. Preventive Medicine 80
1. Animal Biosecurity 80
2. Quarantine and Stabilization 81
3. Separation by Health Status and Species 82
4. Surveillance, Diagnosis, Treatment and Control of Disease 82
C. Clinical Care and Management 84
1. Emergency Care 84
2. Clinical Record keeping 84
3. Diagnostic Resources 84
4. Drug Storage and Control 85
D. Surgery 85
1. Pre-Surgical Planning 85
2. Surgical Facilities 85
3. Surgical Procedures 86
4. Aseptic Technique 86
5. Intraoperative Monitoring 86
6. Postoperative Care 87
E. Pain and Distress 87
F. Anesthesia and Analgesia 87
G. Euthanasia 88
IV. Physical Plant 89
A. Location and Construction Guidelines 89
B. Functional Areas and Operations 90
1. Heating, Ventilation, and Air-Conditioning(HVAC) 90
2. Power and Lighting 90
3. System Malfunctions 91
4. Storage Areas 91
5. Facilities for Sanitizing Materials 92
C. Special Facilities48 92
1. Specialized Types of Animal Housing 92
2. Surgery 92
3. Other Specialized Animal Use Facilities 92
4. Other Animal Support Facilities 93
D. Security and Access Control 93
[Appendices] 94
1. Organizational Chart(s) 95
2. Animal Usage Form A or B 98
3. Summary of Animal Housing and Support Sites 99
4. Line Drawings 102
5. Medical Evaluation Form 108
6. IACUC/OB Membership Roster 109
7. Blank IACUC/OB Protocol Form 110
8/10. Heating, Ventilation and Air Conditioning(HVAC) System Summary 118
9/11. Aquatic Systems Summary 131
10/12. Primary Enclosures and Animal Space Provisions 132
11/13. Cleaning and Disinfection of the Micro- and Macro-Environment 133
12/14. Continuing Education records of Veterinary and Other Professional Staff 136
13/15. Description of facilities that use hazardous agents 138
[부록 2] PSE 및 Site Visit 신청서 사본 142
[부록 3] PSE Site Visit 최종 평가 결과 148
[부록 4] Site Visit Exit Briefing Note 168
판권기 172
〈표 1-1〉 AAALAC 환경조건 List 16
[그림 1] Performance Qualification Validation 절차 17
[그림 2-1] Test Equipment Calibration Verification List-1 26
[그림 2-2] Test Equipment Calibration Verification List-2 27
[그림 3-1] Building(Rooms) System Status Test List-1 28
[그림 3-2] Building(Rooms) System Status Test List-2 29
[그림 4] Summery of Test Results 30
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