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22대 대한민국 국회 국회정보길라잡이 국회의원검색
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소장정보 검색

국회도서관 홈으로 정보검색 소장정보 검색
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결과 내 검색 동의어 포함

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Title page

Contents

Foreword 3

Abstract 7

Graphical Representation 8

Summary of the AOP 9

Molecular Initiating Events (MIEs), Key Events (KEs), Adverse Outcomes (AOs) 9

Key Event Relationships (KERs) 9

Stressors 10

17beta-Trenbolone 10

Overall Assessment of the AOP 11

Domain of Applicability 11

Life Stage Applicability 11

Taxonomic Applicability 11

Sex Applicability 11

Essentiality of the Key Events 12

Weight of Evidence Summary 12

Quantitative Consideration 15

References 16

Appendix 1: List of MIE(s), KE(s) and AO(s) in the AOP 24

List of MIE(s) in this AOP 24

Event: 25: Agonism, Androgen receptor 24

List of KE(s) in the AOP 31

Event: 129: Reduction, Gonadotropins, circulating concentrations 31

Event: 274: Reduction, Testosterone synthesis by ovarian theca cells 34

Event: 3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells 37

Event: 219: Reduction, Plasma 17beta-estradiol concentrations 40

Event: 285: Reduction, Vitellogenin synthesis in liver 43

Event: 221: Reduction, Plasma vitellogenin concentrations 46

Event: 309: Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development 48

Event: 78: Reduction, Cumulative fecundity and spawning 50

List of AO(s) in this AOP 52

Event: 360: Decrease, Population trajectory 52

Appendix 2: List of Key Event Relationships in the AOP 54

List of Adjacent Key Event Relationships 54

Relationship: 31: Agonism, Androgen receptor leads to Reduction, Gonadotropins, circulating concentrations 54

Relationship: 143: Reduction, Gonadotropins, circulating concentrations leads to Reduction, Testosterone synthesis by ovarian theca cells 57

Relationship: 302: Reduction, Testosterone synthesis by ovarian theca cells leads to Reduction, 17beta-estradiol synthesis by ovarian granulosa cells 59

Relationship: 5: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells leads to Reduction, Plasma 17beta-estradiol concentrations 63

Relationship: 252: Reduction, Plasma 17beta-estradiol concentrations leads to Reduction, Vitellogenin synthesis in liver 68

Relationship: 315: Reduction, Vitellogenin synthesis in liver leads to Reduction, Plasma vitellogenin concentrations 72

Relationship: 255: Reduction, Plasma vitellogenin concentrations leads to Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development 75

Relationship: 337: Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development leads to Reduction, Cumulative fecundity and spawning 78

Relationship: 94: Reduction, Cumulative fecundity and spawning leads to Decrease, Population trajectory 81

List of Non Adjacent Key Event Relationships 84

Relationship: 32: Agonism, Androgen receptor leads to Reduction, Testosterone synthesis by ovarian theca cells 84

Relationship: 1384: Agonism, Androgen receptor leads to Reduction, 17beta-estradiol synthesis by ovarian granulosa cells 89

Relationship: 1385: Agonism, Androgen receptor leads to Reduction, Vitellogenin synthesis in liver 92

Relationship: 1386: Reduction, Plasma 17beta-estradiol concentrations leads to Reduction, Plasma vitellogenin concentrations 96

Appendix 3: Concordance Table 101

Tables

Table 1. Summary of the experimental data for decrease E2 production and decreased E2 levels. IC50- half maximal inhibitory concentration values reported if available, otherwise the concentration... 65

Figures

Figure 1. Overview of steroid biosynthesis pathway. Note, testosterone is converted to 17ß-estradiol through aromatization catalyzed by cyp19 (aromatase) 60

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