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Background and Purpose Although plasmapheresis is becoming standard practice as a rescue therapy for neuromyelitis optica (NMO), evidence for the therapeutic efficacy of plasmapheresis is limited, and the effect of plasmapheresis on anti-aquaporin-4 (AQP4) levels in patients with NMO has not been reported. Here, our objective was to evaluate the clinical efficacy of therapeutic plasmapheresis and its effect on anti-AQP4 antibody levels in patients with NMO spectrum disorder (NMOSD). Methods We retrospectively reviewed the medical records of 15 patients with NMOSD who had 18 acute attacks and received plasmapheresis because they did not respond to high-dose intravenous methylprednisolone (IVMP) therapy. Anti-AQP4 antibodies were measured before and after plasmapheresis. The primary outcomes were functional improvements immediately and 6 months after plasmapheresis, and the secondary outcome was the change in anti-AQP4 antibody serum levels following plasmapheresis. Results Plasmapheresis following IVMP therapy led to significant improvement in 50% of the 18 attacks in 15 patients immediately after the procedure was completed, and in 78% (14 attacks) after 6 months. Plasmapheresis was generally well tolerated in all patients. Anti-AQP4 antibody serum levels declined significantly following plasmapheresis, to a mean of 15% of the preplasmapheresis levels. Lower scores on the visual outcome scale recorded before an attack were associated with significant immediate improvement upon the completion of plasmapheresis (p=0.03). Conclusions Plasmapheresis following IVMP therapy effectively removed anti-AQP4 antibodies and was accompanied by a substantial improvement in the neurological disability of patients with NMOSD. Lower levels of pre-existing neurological damage may be associated with an improved acute response to plasmapheresis.

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기사명 저자명 페이지 원문 목차
Autonomic function tests : some clinical applications Phillip A. Low, Victoria A. Tomalia, Ki-Jong Park pp.1-8

Interaction between sleep-disordered breathing and acute ischemic stroke Seong Hwan Ahn, Jin Ho Kim, Dong Uk Kim, In Seong Choo, Hyun Jin Lee, Hoo Won Kim pp.9-13

Short-term and long-term stroke survival : the belgrade prognostic study Sanja Medic, Ljiljana Beslac-Bumbasirevic, Darija Kisic-Tepavcevic, Tatjana Pekmezovic pp.14-20

Decreased metabolism in the cerebral cortex in early-stage Huntington's disease : a possible biomarker of disease progression? Hyeeun Shin, Man Ho Kim, Su Jin Lee, Kyung-Han Lee, Mi-Jung Kim, Ji Sun Kim, Jin Whan Cho pp.21-25

Translation and validation of the Korean version of the 39-item Parkinson's disease questionnaire Do-Young Kwon, Jae Woo Kim, Hyeo-Il Ma, Tae-Beom Ahn, Jinwhan Cho, Phil Hyu Lee, Sun Ju Chung, Joong-Seok Kim, Jong Sam Baik, Seong-Beom Koh pp.26-31

Decremental responses to repetitive nerve stimulation in X-linked bulbospinal muscular atrophy Jee Young Kim, Kee Duk Park, Seung-Min Kim, Il Nam Sunwoo pp.32-35

Clinical efficacy of plasmapheresis in patients with neuromyelitis optica spectrum disorder and effects on circulating anti-aquaporin-4 antibody levels Su-Hyun Kim, Woojun Kim, So-Young Huh, Kyue Yim Lee, In Ja Jung, Ho Jin Kim pp.36-42

Reduced frontal P3a amplitude in migraine patients during the pain-free period Yong Seo Koo, Deokwon Ko, Gwan-Taek Lee, Kyungmi Oh, Myung-Sun Kim, Kyung Hwan Kim, Chang-Hwan Im, Ki-Young Jung pp.43-50

The effect of ropinirole on the quality of life in patients with restless legs syndrome in Korea: an 8-week, multicenter, prospective study Yong Won Cho, Seung Bong Hong, Do Hyung Kim, Ho Won Lee, Eun Yeon Joo, Jee Hyun Kim, Won Chul Shin, Kee Hyung Park, Sun Jung Han, Hyang Woon Lee pp.51-56

Two cases of X-linked myotubular myopathy with novel MTM1 mutations Eun Hye Lee, Mi-Sun Yum, Seong Jong Park, Beom Hee Lee, Gu-Hwan Kim, Han-Wook Yoo, Tae-Sung Ko pp.57-60

Acute myelitis in a patient with Vogt-Koyanagi-Harada disease : case report and review of the literature Shaojuan Gu, Yu Liu, Zhi Song, Xiaohong Zi, Hao Deng pp.61-64

참고문헌 (25건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Plasma exchange in neuroimmunological disorders: Part 1: Rationale and treatment of inflammatory central nervous system disorders. 네이버 미소장
2 A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis 네이버 미소장
3 Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice 네이버 미소장
4 Neuromyelitis optica IgG predicts relapse after longitudinally extensive transverse myelitis 네이버 미소장
5 NMO-IgG predicts the outcome of recurrent optic neuritis. 네이버 미소장
6 Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis optica. 네이버 미소장
7 Neuromyelitis optica. 네이버 미소장
8 New insights into neuromyelitis optica. 소장
9 Plasma exchange for severe attacks of CNS demyelination: predictors of response. 네이버 미소장
10 Plasma exchange for acute attacks of CNS demyelination: Predictors of improvement at 6 months. 네이버 미소장
11 Beneficial plasma exchange response in central nervous system inflammatory demyelination. 네이버 미소장
12 Therapeutic efficacy of plasma exchange in NMO-IgG-positive patients with neuromyelitis optica 네이버 미소장
13 The rescue effect of plasma exchange for neuromyelitis optica. 네이버 미소장
14 Current and future treatment approaches for neuromyelitis optica. 네이버 미소장
15 EFNS guidelines on diagnosis and management of neuromyelitis optica 네이버 미소장
16 Guidelines on the use of therapeutic apheresis in clinical practice--evidence-based approach from the Apheresis Applications Committee of the American Society for Apheresis. 네이버 미소장
17 Revised diagnostic criteria for neuromyelitis optica. 네이버 미소장
18 The spectrum of neuromyelitis optica 네이버 미소장
19 The clinical course of neuromyelitis optica (Devic's syndrome). 네이버 미소장
20 Quantitative measurement of anti-aquaporin-4 antibodies by enzyme-linked immunosorbent assay using purified recombinant human aquaporin-4. 네이버 미소장
21 Narita YM, Hirahara K, Mizukawa Y, Kano Y, Shiohara T. Efficacy of plasmapheresis for the treatment of severe toxic epidermal necrolysis: Is cytokine expression analysis useful in predicting its therapeutic efficacy? J Dermatol 2011;38:236-245. 미소장
22 Plasma exchange in severe spinal attacks associated with neuromyelitis optica spectrum disorder. 네이버 미소장
23 Plasma exchange: why we do what we do. 네이버 미소장
24 Plasma Exchange in Severe Attacks of Neuromyelitis Optica 네이버 미소장
25 Introduction and overview of therapeutic apheresis. 네이버 미소장

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