본문 바로가기 주메뉴 바로가기
22대 대한민국 국회 국회정보길라잡이 국회의원검색
회원가입 로그인
HOME

정보검색

소장정보 검색

국회도서관 홈으로 정보검색 소장정보 검색
결과 내 검색 동의어 포함
결과 내 검색 동의어 포함

-

초록보기



The subacute oral toxicity of 1-(4-methylpiperazinyl)-3-phenylisoquinoline (CWJ- a-5) was investigated in Sprague-Dawley (SD) rats. Five groups of 5 males and 5 females were orally administered at doses of 0, 37.5, 75, 150 and 200 mg/kg with CWJ-a-5 for 2 weeks. In clinical signs, Salivation was observed in the 75, 150 and 500 mg/kg male and female groups. Loss of fur was observed in the 500 mg/kg male and female group. Body weight were significantly decreased in the 150 and 500 mg/kg male groups and in the 500 mg/kg female group. Food consumption was significantly decreased in the 300 mg/kg male group. In serum biochemistry, total cholesterol and phospholipid were significantly increased in 500 mg/kg male and female group. Aspartate aminotransferase was significantly increased in the 500 mg/kg female group. In histopathological examination, vacuolar degeneration of renal tubules in the kidney, vacuolar degeneration of hepatocytes in the liver vacuolar degeneration of myocytes in the heart, vacuolar degeneration of histiocytes in the spleen and thymus, atrophy of seminiferous tubule and degeneration of germinal epithelium in the testis, vacuolar degeneration of corpus luteum, granulosa cell and theca cell in the ovary were observed in the 150 and 500 mg/kg male and female groups. Based on these results, the no observed adverse effect level (NOAEL) with CWJ-a-5 was considered to be 75 mg/kg and the absolute toxic dose was considered to be 150 mg/kg in this study

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
3-Monochloro-1,2-propanediol(3-MCPD)의 안전성 및 위해성 평가 이병무 pp.1-11

Initial Risk Assessment of Acetanilide in OECD High Production Volume Chemical Program Hye-Youn Park 外著 pp.13-22

Initial Risk Assessment of Disodium Disulphite in OECD High Production Volume Chemical Program Sanghwan Song 外著 pp.23-29

A 4-week Repeated Oral Dose Toxicity Study of Plant Sterol Esters in Sprague-Dawley Rats Jong-Choon Kim 外著 pp.31-41

Case Report of Asbestos Exposure-Related Lung Carcinoma Hee Kyung Chang 外著 pp.43-46

1-(4-methylpiperazinyl)-3-phenylisoquinoline(CWJ-a-5)의 Sprague-Dawley(SD) 랫드를 이용한 2주간 반복 경구투여 독성시험 강부현 外著 pp.47-57

LNCaP 세포주를 이용한 내분비계장애물질중 안드로겐성 확인시험을 위한 검색법 김진호 外著 pp.59-64

생식독성과 Benchmark Dose를 활용한 Endosulfan의 노출허용수준 산출 이효민 外著 pp.65-71

마우스 및 랫드에서 자양강장제 황제공진보의 단회투여독성시험 이정남 外著 pp.73-77

YHB216의 토끼에서 국소독성시험 및 마우스에서 소핵시험 강민정 外著 pp.79-85

유전자 재조합 Human Factor Ⅷ(GC-γ AHF)의 안전성에 관한 연구 김민영 外著 pp.87-98
Di(2-ethylhexyl)phthalate의 발암위해성 평가 :MOE(Margin of Exposure) 방법론의 활용 최시내 外著 pp.99-106

추천서가 (다양한 추천 자료를 만나보세요)

권호기사보기

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 기사목차