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? HM10411 is a recombinant granulocyte-colony stimulating factor (rG-CSF) that has been developing

as a drug for neutropenia. In this study, antigenic potential of HM10411 was examined by active systemic

anaphylaxis (ASA) in guinea pigs and passive cutaneous anaphylaxis (PCA) in guinea pig-guinea pig

system. HM10411 was subcutaneously administered at 0, 5, and 50 mg/kg and also as a suspension with adjuvant

(50 mg/kg+FCA). Ovalbumin (OVA) as a suspension with adjuvant was used to induce positive control

responses. In the ASA test, no symptoms except urination and evacuation that were considered as physiological

phenomena were observed at 0 and 5 mg/kg. Two of 5 animals at 50 mg/kg showed sneezing, dyspnea, or

cyanosis. All animals in the adjuvant mixture group showed severe symptoms of anaphylatic shock and 3 of

them died. In the PCA test, no antibody against HM10411 was detected in the sera from the animals sensitized

with 0 or 5 mg/kg. Only 1 serum sample from the animals immunized with 50 mg/kg showed positive reaction

against HM10411, while all 5 sera collected from the HM10411 and FCA mixture group contained the

HM10411-specific antibodies. These results suggest HM10411 is considered to have antigenicity in guinea pig.

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권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Up-regulation of Heme Oxygenase-1 Expression by cAMP-elevating Agents in RAW 264.7 cells Young Shin KO 外著 pp.71-77

세포주와 마우스 조직에서 타우린수송체의 발현분석 안혜숙 外著 pp.78-84

Coumarins from Angelica gigas Roots having Rat Lens Aldose Reductase Activity Sanghyun LEE 外著 pp.85-88

KI-60606의 일반약리작용시험 김은주 ;김현진 ;김동연 pp.89-98

조건적 불사화 흰쥐 뇌 모세혈관 내피세포주에서 Taurine 수송 특성 강영숙 ;이나영 pp.99-103

토끼의 비강, 직장 및 질 점막을 통한 로이신엔케팔린과 [D-알라²]-로이신엔케팔린아미드의 투과 증진 곽혜선 ;박인숙 ;전인구 pp.104-113

새로운 혈액대용제제 PEG-헤모글로빈 SB1의 개에 대한 단회정맥투여 독성시험 한정희 外著 pp.114-116

Type Ⅳ phosphodiesterase inhibitor(CJ-10882)의 개에 대한 2주간 경구반복투여 독성시험 차신우 外著 pp.117-123

Evaluation of Allergenic Potency of an Inactivated Combination Vaccine against Hantaan and Puumala Viruses Using Mice and Guinea Pigs Su Hae LEE 外著 pp.124-128

기니픽에서 HM10411의 항원성 고우석 外著 pp.129-135

참고문헌 (13건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Antigenicity of DA-3030, a Recombinant Human Granulocyte-colony Stimulating Factor, in Guinea Pigs and Mice 네이버 미소장
2 Infection in cancer patients: A continuing association 네이버 미소장
3 Use of Hematopoietic Growth Factors in Elderly Patients Receiving Cytotoxic Chemotherapy 네이버 미소장
4 The Granulocyte-Macrophage Colony-Stimulating Factors 네이버 미소장
5 Disulfide structure and N-glycosylation sites of an extracellular domain of granulocyte-colony stimulating factor receptor. 네이버 미소장
6 Therapeutic effect of HM10411 on neutropema caused by anticancer agents in mice. 미소장
7 Toxicology: Corrigendum to “Comparison of four human studies of perinatal exposure to methylmercury for use in risk assessment” [111 (1996) 157–162] 네이버 미소장
8 Folding and oxidation of recombinant human granulocyte-colony stimulating fac-tor produced in Escherichia coli. Characterization of the disulfide-reduced intermediates and cystem-serine analogs. 미소장
9 Prophylactic granulocyte colony-stimulating factor in patients receiving dose-intensive cancer chemotherapy: a meta-analysis 네이버 미소장
10 Homologous and heterologous passive cutaneous anaphylatic activity of mouse antisera during the course of immunization. 미소장
11 Granulocyte colony stimulating factor and its receptor. In The cytokine handbook (Thompson A. Ed) 미소장
12 Proliferative effects of a recombinant human granu locyte colony-stimulating factor (rG-CSF) on highly eniich ed hematopoietic progenitor cells. 미소장
13 Granulocytopenia and cancer therapy. Past problems, current solutions, future challenges. 네이버 미소장

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