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결과 내 검색 동의어 포함

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초록보기



Diesel exhaust particle (?2.5 μm, DEP2.5) is known to be probarbly carcinogenic (IARC group 2A). DEP2.5

contains organic compounds such as polycyclicaromatic hydrocarbon (PAH), heterocyclic compounds,

phenols, and nitroarenes. Reactive oxygen species (ROS) are generated by DEP2.5 without any biological

activation system. Therefore, an alternative mechanism by which DEP2.5 could be carcinogenic is known by the generation of oxidative DNA damage. The aim of this study was to investigate genotoxic effects of DEP2.5

using single cell gel electrophoresis. In order to evaluate the mechanisms of DEP2.5 genotoxicity, the rat microsome

mediated and DNA repair enzyme treated comet assays together with routine comet assay were performed. DEP2.5 was collected from diesel engine bus and dichloromethane extract was obtained. The organic extract of DEP2.5 revealed DNA damage itself in NIH/3T3 cells. And it showed both oxidative and

microsome mediated DNA damages. Vitamin C as an model antioxidant reduced DNA damage in endonuclase

III treated comet assay. One of flavonoid, galangin as a CYP1A1 inhibitor reduced DNA damage in the

presence of S-9 mixture. Our results show that DEP2.5 are genotoxic and a great source of oxidative stress, but antioxidants can significantly reduce oxidative DNA damages. And DEP2.5 may contain indirect mutagens which can be inhibited by CYP inhibitors.

권호기사

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기사명 저자명 페이지 원문 목차
Distribution of inorganic metals in blood of adults in urban area of Seoul, Korea Ho-hyun Kim ;Young-wook Lim ;Ji-yeon Yang ;Moon-ki Ho ;Dong-chun Shin pp.327-334

디젤분진이 체세포에서의 DNA 손상에 미치는 영향 허 찬 ;김남이 ;정규혁 ;문창규 ;허문영 pp.335-344

A twenty-eight days inhalation toxicity study of N-decane in Sprague Dawley rats Kyung Taek Rim ;Hyeon Young Kim ;Kyung Seuk Song ;Yong Hyun Chung ;Hee Kyung Chang ;Jeong Hee Han ;S pp.345-352

Development of quantitative Vitellogenin ELISAs for goldfish(Carassius auratus) used in endocrine disruptor screening Chun-ri Li ;Kwang-tae Kim ;Andre Kim ;Kyu-hyuck Chung ;Dong-kyoo Kim ;Shin-won Kang ;Jang-su Park pp.353-357

흰쥐에서 divalent metal transporter 1의 조직내 분포와 iron에 의한 조절 최재혁 ;박정덕 pp.359-366

Mancozeb의 아급성 노출이 마우스의 면역병리학적 인자 및 비장세포 증식능에 미치는 영향 표명윤 ;정애희 pp.367-373

산업폐수처리장 방류수의 내분비계 장애작용 평가 오승민 ;김기서 ;유병택 ;장형석 ;이희성 ;정규혁 pp.375-382

한국인 간장 및 신장피질에 함유된 카드뮴, 구리, 수은, 아연 함량과 메탈로치오나인과의 관계 이상기 ;유영찬 ;윤여표 ;양자열 ;오승민 ;정규혁 pp.383-388

카드뮴이 마우스 뇌에서 아연의 항상성에 관여하는 유전자발현에 미치는 영향 박종안 ;여은영 ;남상훈 ;장봉기 ;이종화 ;김완종 pp.389-399

참고문헌 (37건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Rapid chemosensitivity testing of human lung tumor cells using the MTT assay. 네이버 미소장
2 Oxidative DNA damages and lung cancer 미소장
3 Oxidative DNA damage in vitamin C-supplemented guinea pigs after intratracheal instillation of diesel exhaust particles 네이버 미소장
4 Metabolism of polycyclic aromatic hydrocarbons: etiologic role in carcinogenesis. 네이버 미소장
5 BIOMarkers for Occupational Diesel exhaust Exposure Monitoring (BIOMODEM)-a study in underground mining 미소장
6 Mechanisms of genotoxicity of particles and fibers. 네이버 미소장
7 Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes. 네이버 미소장
8 The bioflavonoid galangin blocks aryl hydrocarbon receptor activation and polycyclic aromatic hydrocarbon-induced pre-B cell apoptosis. 네이버 미소장
9 Diesel and gasoline engine exhausts. 네이버 미소장
10 Physiologically Based Pharmacokinetics of Uptake by Inhalation of a Series of 1,1,1-Trihaloethanes: Correlation with Various Physicochemical Parameters 네이버 미소장
11 Complex mixtures of urban air pollutants: identification and comparative assessment of mutagenic and tumorigenic chemicals and emission sources. 네이버 미소장
12 Genotoxic effects of carbon black particles, diesel exhaust particles, and urban air particulates and their extracts on a human alveolar epithelial cell line (A549) and a human monocytic cell line (THP‐1) 네이버 미소장
13 A simple technique for quantitation of low levels of DNA damage in individual cells 네이버 미소장
14 DNA binding of polycyclic aromatic hydrocarbons in a human bronchial epithelial cell line treated with diesel and gasoline particulate extracts and benzo[a]pyrene 네이버 미소장
15 환경백서 미소장
16 Ex-vivo and in vitro protective effects of kolaviron against oxygen-derived radical-induced DNA damage and oxidative stress in human lymphocytes and rat liver cells 네이버 미소장
17 Program summary: Research on Diesel Exhaust 미소장
18 Carcinogenic Effects of Exposure to Diesel Exhaust. NIOSH Current Intelligence Bulletin 50. DHHS (NIOSH) 미소장
19 ML. DNA damage in lung after oral exposure to diesel exhaust particles in Big Blue rats 미소장
20 Lung cancer in rats from prolonged exposure to high concentrations of carbonaceous particles: implication for human risk assessment 미소장
21 Evaluation of benzo(a)pyrene-induced DNA damage in human endothelial cells using alkaline single cell gel electrophoresis. 네이버 미소장
22 DNA adduct formation and oxidative stress in colon and liver of Big Blue(R) rats after dietary exposure to diesel particles 네이버 미소장
23 Diesel and gasoline engine exhausts. 네이버 미소장
24 Involvement of reactive oxygen species in the metabolic pathways triggered by diesel exhaust particles in human airway epithelial cells 미소장
25 Anti-genotoxicity of galangin as a cancer chemopreventive agent candidate 미소장
26 Intake of flavonoids and lung cancer. 네이버 미소장
27 Health Assessment Document for Diesel Emissions: SAB Review Draft. EPA/600/8-90/057D 미소장
28 Inhibition of polycyclic aromatic hydrocarbon-DNA adduct formation in epidermis and lungs of SENCAR mice by naturally occurring plant phenols. 네이버 미소장
29 Validation of raw data measurements in the comet assay. 네이버 미소장
30 Particle-induced oxidative damage is ameliorated by pulmonary antioxidants 네이버 미소장
31 Morphological changes in rat lung after long-term exposure to diesel emissions. 네이버 미소장
32 Diesel exhaust: a critical analysis of emissions, exposure and health effects. A Special Report of the Institute's Diesel Working GrouP 미소장
33 Comparison of the pro-oxidative and proinflammatory effects of organic diesel exhaust particle chemicals in bronchial epithelial cells and macrophages. 네이버 미소장
34 Inhibition of clastogenicity of benzo[a]pyrene and of its trans-7,8-dihydrodiol in mice in vivo by fruits, vegetables, and flavonoids. 네이버 미소장
35 Anticlastogenic effect of flavonoid against mutagen-induced micronuclei in mice 미소장
36 Health effects of diesel exhaust emissions—a mixture of air pollutants of worldwide concern 네이버 미소장
37 Diesel fuel and exhaust emissions. International Program on Chemical Safety 미소장

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