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Bisphenol A (BPA), a environmental endocrine disruptor, is considered to bind to estrogen receptors and to regulate the expressions of estrogen responsive genes. This study was to evaluate the effect of BPA administration on body weight, sex ratio and litter size on 18 days in prenatal periods, the effect of reproductive organ weight and blood hematological values on 24 days postpartum in pregnant mice. The female mice was administrated to low doses of BPA (0, 0.05, 0.5 and 5.0 mg/kg B.W.) by intraperitoneal injection in gestation days 0~15 with 5 times at 3 days interval. The maternal body weight, litter size and sex ratios were similar to in all experimental groups, but body weights of male and female offspring was significantly lower in 5.0 mg BPA group when compared to any other groups (P<0.05). No treatment-related effects on body weight, ovary weight and blood hematological values were observed in dams on 24 days after delivery. The uterine weight in 5.0 mg BPA group was slightly higher than those of any other groups, but not significantly difference. The histological evaluation of ovary in dam mice on 24 days after dilivery was not difference in all experimental groups, but the endometriosis of uterus in dam mice were significantly increased in 0.5 mg BPA group when compared to control group. These results indicates that low concentration of BPA should not be considered as a selective reproductive toxicant.

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기사명 저자명 페이지 원문 목차
나노 독성의 개념 및 나노입자에 대한 위해성 평가의 필요성 맹승희 ;유일재 pp.87-98

광염색체이상시험의 광발암성 예측능력에 대한 평가 홍미영 ;김지영 ;이영미 ;이미가엘 pp.99-105

BARODON^® ^에 의한 human gastric adenocarcinoma AGS 세포고사 조은혜 ;최수일 ;김수림 ;조성대 ;안남식 ;정지원 ;양세란 ;박준석 ;황재웅 ; pp.107-113

Antioxidative activity and irritation response of Lespedeza bicolor Yang-suk Lee ;Zhiqiang Chang ;Seung-chun Park ;Nac-ryong Rim ;Nam-woo Kim pp.115-119

면역독성학적 분석에 의한 축산업 종사자들의 건강 유해성 평가 김형아 ;이경숙 ;김경란 ;김광호 ;허 용 pp.121-128

Styrene-mediated oxidative stresses in rat sperm cells Young-jin Chun ;Hyun Min Lee ;Jee Hye Han ;Young Kun Oh pp.129-134

가족성 해면혈관종에서 염색체 7q CCM1 염기서열의 가족간 연관성 분석 심기범 ;이창섭 ;김승기 ;왕규창 ;김영임 ;조병규 pp.135-140

1,3-Dichloropropanol 흡입에 의한 랫드간의 조직변화에 관한 연구 김성화 ;박오성 ;이성배 ;최종윤 ;권효정 ;손석우 ;박일권 ;이경열 ;손화영 ; pp.141-150

환경호르몬인 p,p-DDE의 흡입 시 ICR 마우스의 폐에 미치는 독성병리학적 연구 최해윤 ;정태영 ;구세광 ;양희복 ;이형식 pp.151-160

임신중인 생쥐에 bisphenol A 투여가 모체의 생식독성과 태아의 성비에 미치는 영향 박동헌 ;장현용 ;김정익 ;정희태 ;박춘근 ;양부근 pp.161-165

임신중인 생쥐에 bisphenol A 투여 후 태어난 차산자의 생식독성과 혈액성분에 관한 연구 박동헌 ;장현용 ;김정익 ;정희태 ;박춘근 ;양부근 pp.167-173

Uterotrophic and hershberger assay for butyl ρ-hydroxybenzoic acid Ji Yun Ahn ;Sung Ran Kim ;Tae Youl Ha ;Sung Su Kim ;Chan Kyu Han pp.175-178

90-day inhalation toxicity of dimethylamine in F344 rats Kyung Seuk Song ;Kun Ho Park ;Jeong Hyun Kim ;Dong Un Han ;Chan Hee Chae ;Sung Jin Park ;Hyun Woo Ki pp.179-186

참고문헌 (16건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
1 (1999) Lack of effects for low dose levels of bisphenol A and diethylstilbestrol on the prostate gland of CF1 mice exposed in utero, 미소장
2 (1999) Tissue compartment-specific estrogen receptor-a participation in the mouse uterine epithelial secretory response, 미소장
3 (1999) Normal reproductive organ develoment in Wistar rats exposed to bisphenol A in the drinking water, 미소장
4 (1987) Degradation of bisphenol A in the natural waters, 미소장
5 (1992) RP-HPLC-TSP-MS of epoxy resins bisphenol A diglycidylether type, 미소장
6 (1981) Testiny of selected workplace chemicals for teratogenic potential, 미소장
7 (1999) Estrogen receptor activation via activation function 2 predicts agonism of xenoestrogen in normal and neoplastic cells of the uterine myometrium, 미소장
8 (1995) Polycarbonate : high-performance resin, 미소장
9 (1997) Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors a and b, 미소장
10 (1981) Interplay between estradiol and prolactin in the regilation of steroid hormone receptor levels nature and functionality in normal mouse mammary tissue, 미소장
11 (2000) Differential effects of xenoestrogen on coactivator recruitment by ERa and ER, 미소장
12 (1996) Effects on testicular development and function, 미소장
13 (1998) A review of the environmental fate effects and exposures of biapnenol A, 미소장
14 (1998) differentiation and c-fos gene expression in the female reproductive tract, 미소장
15 (1999) Prepubertal exposure to compounds that increase prolactin secretion in the male rat effect on the adult prostate, 미소장
16 (1998) A physiologically based approach to the study of bisphenol A and other estrogenic chemicals on the size of reproductive organs, 미소장