본문 바로가기 주메뉴 바로가기
국회도서관 홈으로 정보검색 소장정보 검색

초록보기



The cause and pathogenesis of inflammatory bowel disease remain unknown and no definitetherapy exists until now. The present study was conducted to investigate the anti-inflammatory effectsof a herbal preparation (HemoHIM) in colitis induced by 30 mg of trinitrobenzene sulfonic acid (TNBS)in rats. Sprague-Dawley rats were divided into 5 groups. Each group was treated with 1 mg ofHemoHIM/ml of drinking water, 4 mg of HemoHIM/ml of drinking water, 50 mg of HemoHIM/kgof body weight (i.p. once every other day) or 10 mg/kg of HemoHIMof body weight (i.p. onceevery other day) from the next day. After 2 weeks, rats were sacrificed and morphologic featuresof colons were examined. Ulceration, adhesion, thickening and dilatation were noticed in the colonicmucosa after TNBS instillation. Intraperitoneal injection of HemoHIM (50 and 100 mg/kg of bodyweight) showed the anti-inflammatory effect on adhesion, thickening, dilatation, ulceration, and theinhibition effect on damage score by 72.7% and 90.9%, respectively. Histologically, the colon of TNBS-treated rat showed inflammatory cell infiltration by polymorphonuclear cells, multiple erosive lesionsignificant improvement in these symptoms. The results obtained suggest marked anti-inflamatoryactivity of the HemoHIM at the dose levels examined.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
원유 및 젖샘조직 내 osteopontin의 동정 강재윤 ;김희철 ;김동식 ;지영흔 ;신태균 pp.1-6

흰쥐 왼쪽관상동맥의 분지 양상에 관한 해부학적 연구 안동춘 ;김인식 pp.7-17

Trinitrobenzene sulfonic acid에 의해 유발된 랫드의 대장염에서 HemoHIM의 항염증 효과 이해준 ;김세라 ;문창종 ;김종춘 ;배춘식 ;강성수 ;정우희 ;박혜란 ;조성기 ; pp.19-24

비 지질 산화손상에 대한 어성초 뿌리의 항산화 효과 하대식 ;김충희 ;김의경 ;강정부 ;김종수 pp.25-32

젖소 유방염 유즙에서 분리한 Streptococcus uberis의 항생제 감수성 및 유전학적 특성 이 길 ;강현미 ;정충일 ;문진산 pp.33-41

개에서 분리한 Staphylococcus aureus와 S. intermedius의 항생제 감수성 변정혜 ;김태중 pp.43-50

우리나라 돼지콜레라 항체 수준 측정을 위한 표본검사의 통계학적 기준 설정 윤하정 ;남향미 ;박최규 ;김병한 ;박지용 ;송재영 ;현방훈 ;위성환 pp.51-57

보기
돼지 위축성 비염 단위 백신 개발을 위한 재조합 파스튜렐라 독소 단백질의 면역원성 검정 이정민 pp.59-65

젖소 유방염으로부터 분리한 그람음성균의 분포 및 항생제 감수성 이은실 ;강현미 ;정충일 ;문진산 pp.67-75

Helicobacter pylori의 감수성과 숙주 연령과의 상관성 연구 이진욱 ;김승희 ;박탄우 ;김옥진 pp.77-84

Multicentric T cell lymphoma in a maltese dog Ji-youl Jung ;Sang-chul Kang ;In-soon Roh ;Hyun-joo Sohn ;Young-min Yun ;Jung-hun Kim ;Kyoung-kap Le pp.85-89

Cutaneous asthenia associated with Ehlers-Danlos syndrome in a Yorkshire terrier Sung-jin Cho ;Okjin Kim pp.91-94

Degenerative joint disease with systemic mycoses in a oriental white stork Sook-jin Lee ;Je-ik Han ;Dong-woo Chang ;Ki-jeong Na pp.95-98

A case of pulmonic stenosis in a Shihtzu dog Chul Park ;Jong-hyun Yoo ;Dong-in Jung ;Ju-won Kim ;Byeong-teck Kang ;Hee-myung Park pp.99-102

Isoflurane으로 마치된 개에 medetomidine, medetomidine-buprenorphine, medetomidine-fentanyl의 경막외 투여 시 심혈관계 반응과 진통효과의 비교 장화석 ;김혜진 ;최치봉 ;이정선 ;김휘율 pp.103-115

자가골 이식에서 이식골편의 처리방법에 따른 골형성능력 비교 이종일 ;송하나 ;김남수 ;최인혁 pp.117-125

Identification of intracerebral hematoma using ultrasonography in a dog Dong-in Jung ;Chul Park ;Byeong-teck Kang ;Jong-hyun Yoo ;Ju-won Kim ;Ha-jung Kim ;Chae-young Lim ;S pp.127-129

개에서 담낭 점액낭종에 의한 담낭 파열 3례 최지혜 ;김현욱 ;반현정 ;김진경 ;장재영 ;김혜진 ;서지민 ;이민정 ;윤정희 pp.131-134

Successful pregnancy following surgical intrauterine insemination using frozen semen in Afghan hound dog Hye Jin Kim ;Hyun Ju Oh ;Goo Jang ;Jung Hee Yoon ;Hyung Suk Lee ;Sang Cheol Kim ;Cheol Young Hwang ; pp.135-138

참고문헌 (28건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 김성호, (2004) 시작품의 장기간 섭취, 최기형성 및 국소독성에 대한 안전성 평가, 한국원자력연구소 미소장
2 이해준 ; 김세라 ; 김종춘 ; 배춘식 ; 조성기 ; 정우희 ; 박혜란 ; 김성호, (2005) 생약복합조성물(HemoHIM?)의 항염증작용, Laboratory Animal Research 미소장
3 Ahlstedt S, (scandjgastroenterol1990) Characteristics of immunecomplex-induced chronic experimental colitis in rats with a therapeutic effect of sulphasalazine, 미소장
4 Cho CH, (2000) Study of the gastrointestinal protective effects of polysaccharides from Angelica sinensis in rats, 미소장
5 Choi YE, (2000) Polyacetylenes from angelica gigas and their inhibitory activity on nitric oxide synthesis in activated macrophages, 미소장
6 Dai Y, (2002) Antipruritic and antiinflammatory effects of aqueous extract from Si-Wu-Tang, 미소장
7 Jo SK, (2005) Protective effect of a herbal preparation (HemoHIM) on the self-renewal tissues and immune system against r-irradiation, 미소장
8 Jo SK, (2000) The effects of Shi-Quan-Dai-Bu-Tang and its ingredients on the survival of jejunal crypt cells and hematopoietic cells in irra-diated mice, 미소장
9 Kim JJ, (1996) The effect of anti-inflammatory drugs on colitis induced by trinitrobenzene sulfonic acid in rats, 미소장
10 Kim SH, (2001) The effects of herbs on the radiation-induced apoptosis in intestinal crypt cells, 미소장
11 Kim SH, (2002) The radioprotective effects of Bu-Zhong-Yi-Qi-Tang: A prescription of traditional Chinese medicine, 미소장
12 Kim SH, (1999) The radioprotective effect of Kuei- Pi-Tang as a prescription of traditional Chinese medicine in mice, 미소장
13 Kim SH, (2001) The radioprotective effects of radices herbs, 미소장
14 Kim SH, (1998) Effect of Si-Wu-Tang and Si-Jun-Zi-Tang on the survival of jejunal crypt cells and hematopoietic cells in irradiated mice, 미소장
15 Lee SE, (1999) Radioprotective effects of two traditional Chinese medicine prescriptions: si-wu-tang and si-junzi- tang, 미소장
16 Lu ZM, (2005) The protective effects of Radix Astragali and Rhizoma Ligustici Chuanxiong on endothelial dysfunction in type 2 diabetic patients with microalbuminuria, 미소장
17 Morris GP, (1989) Hapten-induced model of chronic inflammation and ulceration in the rat colon, 미소장
18 Oh H, (2002) Protective effects of Paeonia japonica against radiationinduced dam-age, 미소장
19 Park HR, (2005) Effect of a herb mixture (HIM-I) on the protection of the hematopoietic-immune system and self-renewal tissues against radiation damage, 미소장
20 Pullman WE, (gastroenterology1992) Enhanced mucosal cytokine production in inflammatory bowel disease, 미소장
21 Simon PL, (gastroenterology1989) Inflammatory mediators of experimental colitis in rats, 미소장
22 Robbins SL, (1994) Pathologic Basis of Disease, 미소장
23 Sartor RB, (gastroenterology1994) Cytokines in intestinal inflammation, 미소장
24 (digdissci1985) Animal models of inflammatory bowel disease-an overview, 미소장
25 Salas A, (gastroenterology1990) Participation of thromboxane and other eicosanoid synthesis in the course of experimental inflammatory colitis, 미소장
26 Wallace JL, Release of platelet-activating factor and accelerated healing induced by a PAF antagonist in an animal model of chronic colitis, 미소장
27 Yamada Y, (gastroenterology1992) A comparative analysis of two models of colitis in rats, 미소장
28 Nast CC, (gastroenterology1987) In vivo production of leukotriene B4 and leukotriene C4 in rabbit colitis Relationship to inflammation, 미소장