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대표형(전거형, Authority) | 생물정보 | 이형(異形, Variant) | 소속 | 직위 | 직업 | 활동분야 | 주기 | 서지 | |
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The mouse hepatitis virus (MHV-2) induces broad collapses, focal necrosis and cytolysis of hepatocytes, and
leads to death after three to five days of intraperitoneal injection in mice. The present study investigated whether the combinatorial
treatment of dimethyl dicarboxylate/amantadine (2 : 1) showed hepatoprotective and/or antiviral properties in
MHV-2 infected ICR mice. In the study, we found that dimethyl dicarboxylate/amantadine group (VDDBA) increased the
survival rate (30.8%) when compared to positive control, VL (7.7%) and that VDDBA lengthened the survival time (4.2 d)
after MHV-2 infection. In addition, ALT and AST were well regulated when treated with VDDBA (p<0.01). Finally, we concluded
that those results were probably from the inhibition of viral replication and at least antiproliferative effect on MHV-2.번호 | 참고문헌 | 국회도서관 소장유무 |
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1 | (2002) Chronic hepatitis B, | 미소장 |
2 | (2005) Hepatocellular carcinoma in Korea introduction and overview, | 미소장 |
3 | (1989) Hepatitis B virus structure and biology, | 미소장 |
4 | (2007) Prevalence of occult HBV infection among subjects with normal serum ALT levels in Korea, | 미소장 |
5 | (1993) Effect of alpha-interferon treatment in patients with hepatitis B e antigen-positive chronic hepatitis B, | 미소장 |
6 | (2000) Effects of extended lamivudine therapy in Asian patients with chronic hepatitis B, | 미소장 |
7 | (2004) Antiviral drugs in current clinical use, | 미소장 |
8 | (2002) The anti fibrogenic effect of a pharmaceutical composition of and dimethyl 4 4 dimethoxy 5 6 5 6' dimethylene dioxybiphenyl 2 2 dicarboxylate , | 미소장 |
9 | (2006) The M2 proton channels of influenza A and B viruses, | 미소장 |
10 | (1993) Ion channel activity of influenza A virus M2 protein characterization of the amantadine block, | 미소장 |
11 | (2006) Interferon signal transduction of biphenyl dimethyl dicar boxylate amantadine and anti HBV activity in HepG2 2, | 미소장 |
12 | (1995) Spread of a neurotropic coronavirus to spinal cord white matter via neurons and astrocytes, | 미소장 |
13 | (1995) Neurovirulence test for oral live poliovaccines using poliovirus sensitive transgenic mice, | 미소장 |
14 | (1976) Preparation of isolated rat liver cells, | 미소장 |
15 | (2000) Protective effects of murine recombinant interferon b administered by intravenous intramuscular or subcutaneous route on mouse hepatitis virus infection, | 미소장 |
16 | (2005) The potential anti HBV effect of amantadine in combination with ursodeoxycholic acid and biphenyl dimethyl dicarboxylate in HepG2 2, | 미소장 |
17 | (2003) Synergistic antiviral effect of a combination of mouse interferon alpha and interferon gamma on mouse hepatitis virus, | 미소장 |
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