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초록보기

Scutellaria barbata was examined to evaluate its modulatory effects on the functional activation of macrophages

under lipopolysaccharide (LPS) treatment. To do this, hot water extract (Sb-HWE) was prepared from Scutellaria barbata

and several inflammatory parameters such as nitric oxide (NO) production, phagocytosis, reactive oxygen species

(ROS) determination and intracellular signaling pathway were selected to be tested. Sb-HWE strongly blocked NO production

in LPS-activated RAW264.7 cells in a dose-dependent manner. However, it did not suppress inducible NO synthase

(iNOS). In agreement, Sb-HWE did not diminish inflammatory signaling composed of NF-κB and its upstream activation

signaling enzymes such as Akt and IκBα. Sb-HWE protected RAW264.7 cells from LPS-induced cytotoxicity up to 80% at

400㎍/㎖. Furthermore, this extract blocked phagocytic uptake of FITC-dextran, while sodium nitroprusside (SNP)-

induced ROS generation in RAW264.7 cells was not decreased. Therefore, our data suggest that Sb-HWE may have differential

immunoregulatory function depending on macrophage-mediated immune responses.

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기사명 저자명 페이지 원문 목차
Self-incompatibility and embryo development in Astragali radix Young Guk Kim ;Hong Seob Yu ;Nak Sul Seong ;Ho Ki Park ;Seok Yong Son pp.287-293

병풀의 초음파 추출 시 용매에 따른 면역활성 증진 효과 권민철 ;한재건 ;하지혜 ;오성호 ;김 영 ;정향숙 ;최근표 ;황 백 ;이현용 pp.294-300

아주까리(비麻子) 수집종의 조지방 및 지방산 분석 김인재 ;남상영 ;김민자 ;노창우 ;윤 태 ;김홍식 ;송항림 ;정헌상 pp.301-305

수확시기에 따른 구기자 품종의 성분변화 이희철 ;이봉춘 ;김수동 ;이가순 ;백승우 ;이석수 ;김성민 pp.306-312

반지련 (Scutellaria barbata D. Don) 추출물이 lipopolysaccharide에 의해 활성화된 대식세포에 미치는 영향 센팅 ;이용진 ;조재열 pp.313-319

후박추출물의 나노입자화를 통한 치콘의 저장기간 연장 권민철 ;한재건 ;하지혜 ;김 영 ;최근표 ;박욱연 ;이달호 ;이현용 pp.320-325

Extracts of Artemisia princeps pampanini inhibit lipopolysaccharide-induced nitric oxide, cyclooxygenase-2, prostaglandin E₂, and tumor necrosis factor-α production from murine macrophage RAW 264.7 cells Jun-yong Yun ;Se-Yong Choi ;Pyo Jam Park ;Hae Gon Chung ;Heung Mook Shin ;Kyoungho Suk ;Beong Ou Lim pp.326-331

Changes of protopanaxadiol ginsenosides in ginseng leaves by far infrared and steaming heat treatments Seok Hyun Eom ;Su Hyun Seo ;Amal Kumal Gimery ;Cheng Wu Jin ;Eun Young Kang ;Wie Soo Kang ;Ill Min C pp.332-336

갯방풍의 자생지역별 지방산 조성과 phytosterols의 함량 김성민 ;신동일 ;송홍선 ;윤성탁 pp.337-340

Screening for human ACAT-2 and ACAT-2 inhibitory activity of edible plant extracts Dae young Lee ;Tae Sook Jeong ;Ha Na Lyu ;Myun Ho Bang ;Yoon Hee Hong ;Youn Hyung Lee ;Nam IN Baek pp.341-348

곰의말채 부위별 추출물의 항암 및 면역증진 효과 김 영 ;한재건 ;하지혜 ;정향숙 ;김철희 ;권민철 ;이학주 ;강하영 ;최근표 ;이 pp.349-355

식물자원의 항산화활성 탐색 이승은 ;성정숙 ;장인복 ;김금숙 ;안태진 ;한희선 ;김지은 ;김영옥 ;박충범 ; pp.356-370

남한 개모시풀의 자생지 환경특성과 혼생식물종 분포 김성민 ;신동일 ;송홍선 ;윤성탁 ;조용구 pp.371-375

참고문헌 (27건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Nitric oxide, oxidative stress, and apoptosis. 네이버 미소장
2 Chen F, (2002) NF-kappaB, a pivotal transcription factor in silica-induced diseases, Mol. Cell. Biochem 미소장
3 Chen LG, Wogonin, a bioactive flavonoid in herbal tea, inhibits inflammatory cyclooxygenase-2 gene expression in human lung epithelial cancer cells, Mol. Nutr. Food Res. May 21. [Epub ahead of print]. 미소장
4 Inhibitory Effect of Extracts from Woody Plants on Tumor Necrosis Factor-α Production in Lipopolysaccharide-Stimulated RAW264.7 cells 소장
5 Cho JY, (2001) Savinin, a lignan from Pterocarpus santalinus inhibits tumor necrosis factor-alpha production and T cell proliferation, Biol. Pharm. Bull 미소장
6 New neo-Clerodane Diterpenoid Alkaloids from Scutellaria barbata with Cytotoxic Activities 네이버 미소장
7 Five new neo-clerodane diterpenoid alkaloids from Scutellaria barbata with cytotoxic activities. 네이버 미소장
8 Blockade of NF-kappaB activation and donation of nitric oxide: new treatment options in inflammatory bowel disease? 네이버 미소장
9 Biochemical and functional characterization of three activated macrophage populations. 네이버 미소장
10 Lipopolysaccharide-induced macrophage inflammatory response is regulated by SHIP. 네이버 미소장
11 Signaling by the Respiratory Burst in Macrophages 네이버 미소장
12 Science and Technology Medalists 네이버 미소장
13 Polyphenolic antioxidant (-)-epigallocatechin-3-gallate from green tea reduces UVB-induced inflammatory responses and infiltration of leukocytes in human skin. 네이버 미소장
14 Dual effect of nitric oxide in immortalized and malignant human oral keratinocytes: induction of apoptosis and differentiation 네이버 미소장
15 Immunomodulatory effect of Hibiscus cannabinus extract on macrophage functions 네이버 미소장
16 Inhibitory Effect of Extracts from Woody Plants on Tumor Necrosis Factor-α Production in Lipopolysaccharide-Stimulated RAW264.7 cells 소장
17 Regulatory effects of Codonopsis lanceolata on macrophage-mediated immune responses 네이버 미소장
18 Src kinase‐targeted anti‐inflammatory activity of davallialactone from Inonotus xeranticus in lipopolysaccharide‐activated RAW264.7 cells 네이버 미소장
19 Anti‐inflammatory effect of heme oxygenase 1: Glycosylation and nitric oxide inhibition in macrophages 네이버 미소장
20 AH23848 accelerates inducible nitric oxide synthase degradation through attenuation of cAMP signaling in glomerular mesangial cells. 네이버 미소장
21 Exercise and the Nitric Oxide Vasodilator System 네이버 미소장
22 Apoptosis and Aging: Role of p66Shc Redox Protein 네이버 미소장
23 Sato Y, (2000) Phytochemical flavones isolated from Scutellaria barbata and antibacterial activity against methicillin-resistant Staphylococcus aureus, J. Ethnopharmacol 미소장
24 Phagocytosis and antigen presentation in dendritic cells 네이버 미소장
25 Chemoprevention of Scutellaria bardata on human cancer cells and tumorigenesis in skin cancer 네이버 미소장
26 Nitric oxide: a key regulator of myeloid inflammatory cell apoptosis 네이버 미소장
27 Inflammatory cells and chronic obstructive pulmonary disease. 네이버 미소장

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