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초록보기
In an effort to elucidate the differential actions of blueberry(BB) in both normal and cancer cells, we utilized human
breast cell lines to assess the accumulation of radical oxygen species(ROS) and ROS-associated apoptosis in both human
normal breast epithelial(MCF10A) and breast cancer(MCF7) cells. BB extract was added to the cultures at a final concentration
of 20 ㎍/㎖ for 0(control), 6, 12, and 24 hr intervals. The MCF10A cells evidenced no marked ROS accumulation
in the presence of BB, whereas the MCF7 cells evidenced clear ROS accumulation upon BB treatment from 12 hours
forward. The number of dying or dead cells did not increase in the BB-treated MCF10A cell groups, whereas that number
increased profoundly from 12 hr forward. Furthermore, the expression levels of certain stress-related, and pro- and antiapoptotic
gene products evidenced differential responses to BB treatment between the MCF10A and MCF7 cell groups.
These results indicate that the components of BB extract differentiate cancer cells by not preventing ROS accumulation
within cells and by inducing ROS-associated cell death in cancer cells. However, no marked ROS accumulation or induction
of cell death was noted in the normal breast epithelial cells. The fact that BB extract exerted a differential effect on cancer
cells opens further directions of research regarding the specific components that exert the differential BB-mediated effects
in the selective prevention of normal cells and therapy for cancer tissues in the physiological body.권호기사
참고문헌 (29건) : 자료제공( 네이버학술정보 )
| 번호 | 참고문헌 | 국회도서관 소장유무 |
|---|---|---|
| 1 | Naczk, M., (2006) Phenolics in cereals, fruits and vegetables: Occurrence, extraction and analysis, J. Pharm. Biomed. Anal | 미소장 |
| 2 | Hertog, M. G. L., (1997) Antioxidant flavonols and coronary heart disease risk, Lancet | 미소장 |
| 3 | Flavonoid Intake And Coronary Mortality In Finland: A Cohort Study  |
미소장 |
| 4 | Dietary flavonoids, antioxidant vitamins, and incidence of stroke: the Zutphen study. |
미소장 |
| 5 | Dietary flavonoids and the risk of lung cancer and other malignant neoplasms. |
미소장 |
| 6 | Bagchi, D, (2004) Anti-angiogenic, antioxidant, and anti-carcinogenic properties of a novel anthocyanin-rich berry extract formula, Biochem | 미소장 |
| 7 | Screening of selected flavonoids and phenolic acids in 19 berries |
미소장 |
| 8 | Cell transplantation: stem cells in the spotlight. |
미소장 |
| 9 | Bioactive Properties of Wild Blueberry Fruits |
미소장 |
| 10 | Anticarcinogenic Activity of Strawberry, Blueberry, and Raspberry Extracts to Breast and Cervical Cancer Cells |
미소장 |
| 11 | Antimutagenic activity of berry extracts | 소장 |
| 12 | Cranberry and blueberry: evidence for protective effects against cancer and vascular diseases. |
미소장 |
| 13 | Phenolic compounds from blueberries can inhibit colon cancer cell proliferation and induce apoptosis. |
미소장 |
| 14 | Inhibition of cancer cell proliferation in vitro by fruit and berry extracts and correlations with antioxidant levels. |
미소장 |
| 15 | Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro. |
미소장 |
| 16 | Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10. |
미소장 |
| 17 | Cathepsin D in breast cancer cells can digest extracellular matrix in large acidic vesicles. |
미소장 |
| 18 | Flow cytometric analysis of respiratory burst activity in phagocytes with hydroethidine and 2',7'-dichlorofluorescin. |
미소장 |
| 19 | Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction |
미소장 |
| 20 | Oxidative stress as a mediator of apoptosis |
미소장 |
| 21 | Superoxide dismutase delays neuronal apoptosis: A role for reactive oxygen species in programmed neuronal death |
미소장 |
| 22 | ROS, stress-activated kinases and stress signaling in cancer. |
미소장 |
| 23 | Catechin and proanthocyanidin B4 from grape seeds prevent doxorubicin-induced toxicity in cardiomyocytes |
미소장 |
| 24 | Breast cancer risk assessment models |
미소장 |
| 25 | Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms. |
미소장 |
| 26 | Cyclooxygenase-2 expression during immortalization and breast cancer progression. |
미소장 |
| 27 | Bcl-2 and the Regulation of Programmed Cell Death |
미소장 |
| 28 | bcl-2 in normal human breast and carcinoma, association with oestrogen receptor-positive, epidermal growth factor receptor-negative tumours and in situ cancer. |
미소장 |
| 29 | Anthocyanin fraction from potato extracts is cytotoxic to prostate cancer cells through activation of caspase-dependent and caspase-independent pathways |
미소장 |
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도서위치안내: 정기간행물실(524호) / 서가번호: 국내13
2021년 이전 정기간행물은 온라인 신청(원문 구축 자료는 원문 이용)
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