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초록보기

Obesity has become one of the main public health problems. Saussurea lappa (Asteraceae), syn Aucklandia

lappa and Saussurea costus, is a well-known herbal medicine that has been used for treating various ailments, such as

inflammatory and gastrointestinal diseases. The present study examined the anti-obesity effect of S. lappa extract (SLE) in

3T3-L1 adipocytes and high fat diet (HFD)-induced obese mouse model. SLE significantly inhibited the differentiation from

preadipocytes to adipocytes of cultured 3T3-L1 in dose-dependent manner. In addition, SLE significantly decreased the

body weight gain and the food efficiency ratio of mice fed HFD during 9 weeks. Further study must be performed for the

pharmacological mechanism and safety of SLE as well as the identification of active compound in SLE. Our results revealed

that S. lappa suppresses the adipogenesis in cultured cells and the obesity in rodent models. Therefore, S. lappa may be useful

toward the development of new potent anti-obesity drugs.

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기사명 저자명 페이지 원문 목차
상황 균사체 배양에 의한 파삼의 항암 활성 증진 하지혜 ;정명훈 ;서용창 ;최운용 ;정헌상 ;정재헌 ;유광원 ;이현용 pp.135-142

마황 추출물의 나노 입자화를 통한 항암 활성 증진 정향숙 ;김승섭 ;오성호 ;정명훈 ;최운용 ;서용창 ;나천수 ;곽형근 ;이현용 pp.143-150

Anti-obesity activity of extract from Saussurea lappa Tae Sook Yoon ;Yoon Young Sung ;Ja Young Jang ;Won Kyung Yang ;Yunui Ji ;Ho Kyoung Kim pp.151-156

초고압 추출 공정을 통한 고로쇠 목부 추출물의 항암활성 증진 정명훈 ;최운용 ;서용창 ;강하영 ;최근표 ;이현용 pp.157-167

유기질 퇴비 시용이 황금의 생육 및 수량에 미치는 영향 김명석 ;최진경 ;김희권 ;정병준 ;방극필 ;김정근 ;박민수 ;안영섭 ;김영국 ; pp.168-172

현삼속 식물의 종판별을 위한 Mitochondrial DNA의 염기서열 및 PCR-RFLP 분석 이정훈 ;조익현 ;이제완 ;박춘근 ;방경환 ;김홍식 ;박충범 pp.173-179

Genetic diversity and genetic structures in ginseng landraces (cultivars) by SRAP analysis Yong Hua Xu ;Hui Jin ;Young Chang Kim ;Kyong Hwan Bang ;Seon Woo Cha ;Lian Xue Zhang pp.180-185

5S와 45S rDNA 유전자를 이용한 제주도산 애기더덕 (Codonopsis minima)과 더덕 (C. lanceolata)의 FISH 패턴 분석 김수영 ;김찬수 pp.186-190

Effects of temperature and UV irradiation on stability of anthocyanin-polyphenol copigment complex in mulberry fruits In Soo Bang ;Chang Yeon Yu ;Jung Dae Lim pp.191-200

품종이 다른 여우구슬 추출물의 항산화 효과 김태수 ;김진숙 ;박춘근 ;박소이 ;주영운 ;강명화 pp.201-207

참고문헌 (34건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Beneficial role of dietary phytoestrogens in obesity and diabetes. 네이버 미소장
2 Medicinal strategies in the treatment of obesity. 네이버 미소장
3 High-fat diets: modeling the metabolic disorders of human obesity in rodents. 네이버 미소장
4 Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. 네이버 미소장
5 Active compounds from Saussurea lappa Clarks that suppress hepatitis B virus surface antigen gene expression in human hepatoma cells 네이버 미소장
6 [Effect of Saussurea lappa on gastric functions]. 네이버 미소장
7 Cytotoxic and pro-apoptotic activities of cynaropicrin, a sesquiterpene lactone, on the viability of leukocyte cancer cell lines 네이버 미소장
8 Inhibitory effect of sesquiterpene lactones from Saussurea lappa on tumor necrosis factor-alpha production in murine macrophage-like cells. 네이버 미소장
9 Feve B. (2005). Adipogenesis: cellular and molecular aspects. Best Practice & Research Clinical Endocrinology & Metabolism. 19:483-499. 미소장
10 Leptin and the regulation of body weight in mammals. 네이버 미소장
11 Costunolide, a sesquiterpene lactone from Saussurea lappa, inhibits the VEGFR KDR/Flk-1 signaling pathway 네이버 미소장
12 Hibiscus sabdariffa L. water extract inhibits the adipocyte differentiation through the PI3-K and MAPK pathway 네이버 미소장
13 Saussurea lappa induces G2-growth arrest and apoptosis in AGS gastric cancer cells 네이버 미소장
14 Obesity as a medical problem. 네이버 미소장
15 Obesity and colorectal cancer 네이버 미소장
16 Inhibitory effects of Oriental herbal medicines on IL-8 induction in lipopolysaccharide-activated rat macrophages. 네이버 미소장
17 Amelioration of Plasma Glucose and Cholesterol levels in Db/db Mice by a Mixture of Chinese Herbs 소장
18 Screening of biological activities of the extracts from Rubus coreanus Miq 소장
19 Plasma adiponectin decrease in women with nonalcoholic Fatty liver. 네이버 미소장
20 Absolute Stereostructures and Syntheses of Saussureamines A, B, C, D and E, Amino Acid–Sesquiterpene Conjugates with Gastroprotective Effect, from the Roots of Saussurea lappa 네이버 미소장
21 Adipokines: implications for female fertility and obesity. 네이버 미소장
22 Effects of green tea catechin‐induced lipolysis on cytosol glycerol content in differentiated 3T3‐L1 cells 네이버 미소장
23 Dehydrocostus lactone enhances tumor necrosis factor-alpha-induced apoptosis of human leukemia HL-60 cells. 네이버 미소장
24 Pandey MM, Rastogi S and Rawat AK. (2007). Saussurea costus: botanical, chemical and pharmacological review of an ayurvedic medicinal plant. Journal of Ethnopharmacology. 110:379-390. 미소장
25 The obesity epidemic: pathophysiology and consequences of obesity. 네이버 미소장
26 A new sesquiterpene lactone from the roots of Saussurea lappa: Structure–anticancer activity study 네이버 미소장
27 The transcriptional basis of adipocyte development 네이버 미소장
28 Monocyte Chemoattractant Protein 1 in Obesity and Insulin Resistance 네이버 미소장
29 Vasoactive Substances from Saussurea lappa 네이버 미소장
30 Costunolide and dehydrocostus lactone as inhibitors of killing function of cytotoxic T lymphocytes. 네이버 미소장
31 Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. 네이버 미소장
32 Serum leptin levels in patients with nonalcoholic steatohepatitis 네이버 미소장
33 Obesity Hypertension in the Atherosclerosis Risk in Communities Cohort: Implications of Obesity Guidelines. 네이버 미소장
34 Saussurea lappa inhibits the growth, acid production, adhesion, and water-insoluble glucan synthesis of Streptococcus mutans 네이버 미소장

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