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Background : Despite recent advances in cancer management, prognosis of ovarian cancer is poor. Anticancer effects of herbal medicine, such as Euonymus alatus Sieb, Oldenlandia diffusa (Willd.) Roxburgh, and Orostachys japonicus A. Berger, have been reported in treatment of ovarian and cervical cancers, but the systematic approaches to explain their molecular mechanism(s) have not yet been established. Objectives : To establish a basis of understanding for anti-cancer mechanisms of herbal medicine, we profiled protein expression in human ovarian and cervical cancer cells treated with the extracts from Euonymus alatus Sieb, Oldenlandia diffusa (Willd.) Roxburgh and Orostachys japonicus A. Berger. Methods : Human ovarian cancer cell line NIH:OVCAR-3, and human cervical cancer cell line HeLa were employed in the present study. Whole protein was obtained from the cells harvested at 48 hours after the treatment with herbal water-extract, and analyzed by 2DE-based proteomic approach. Results : Various changes of protein expression induced by the herbal treatment were monitored : down-regulation of molecular chaperone (calreticulin variant), glycolytic enzymes (D-3-phosphoglycerate dehydrogenase, glyceraldehyde 3-phosphate dehydrogenase and alpha-enolase), RNA processing molecules (hnRNP A2/B1), and antioxidant protein (peroxiredoxin 1). Conclusions : Repression of glycolysis has been accepted as the mechanism to increase anticancer reagent's effect. Thus, down-regulation of glycolytic enzymes by the herbal extracts suggested a possible synergistic effect of herbs in the presence of platinum-based therapeutics. In further study, as well as the synergistic effect of the herbs, it has to be further validated whether artificial regulation of hnRNP A2/B1 in ovarian cancer cells affects various cancer survival factors, since RNA processing can be interrupted by deranged expression of hnRNP subtypes, and it results in an inhibition of cancer cell growth.

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기사명 저자명 페이지 원문 목차
Phenylhydrazine으로 유발된 흰쥐의 용혈성 빈혈에 미치는 三七根의 효과 이재열 ,이장훈 pp.1-9

기관지천식 환자의 효과적인 치료를 위한 淸上補下湯의 임상적 관찰 방지현 ,정희재 ,정승기 pp.10-25

비알콜성지방간의 유병율과 병리기전에 대한 문헌적 고찰 박연화 ,유사라 ,손창규 pp.26-32

귀전우, 백화사설초, 와송 추출물을 처치한 난소암과 자궁경부암 세포에서의 단백질 발현 변화 김경순 ,예성철 ,유병철 ,조종관 ,이연월 ,유화승 pp.33-42

續命湯이 C6 glial cell 보호 및 허혈성 뇌손상에 미치는 영향 안가영 ,최은희 ,김인수 ,강성순 ,이영수 ,홍석 ,전상윤 pp.43-55

고농도 포도당에 노출된 마우스 신장상피세포에서 桑枝의 산화 스트레스 억제 효과 장수영 ,신현철 pp.56-67

赤石脂散과 托裏消毒飮의 火傷治療 효과 이대현 ,한현진 ,서의석 ,정현숙 ,강세영 ,장인수 pp.68-74

역류성 식도염의 변증과 처방에 관한 문헌적 고찰 :중국 논문 중심으로 최가영 ,선승호 ,김병우 ,이선주 ,오현석 ,한인식 ,고재언 pp.75-86

徐靈胎와 吉益東洞의 학술사상 비교 연구 .2 ,학술 사상이 같고 다른 원인에 대한 분석 尹哲浩 ,黃煌 pp.87-99

Effects of electroaccupuncture in immobilization stress responses :a study on inhibitory avoidance task, forced swimming test, and stress hormones So-yeon Kwon ,Min-soo Kim ,Sang-kwan Lee ,Jun-tae Je ,Jae-gun Oh ,Jong-deok Lee ,Kang-keyng Sung pp.100-112

진행성 비소세포성 폐암환자에 대한 항암플러스의 치료효능 :연속증례보고 정홍매 ,윤정원 ,이연월 ,조종관 ,오달석 ,유화승 pp.113-120

메니에르 병 환자의 虛實別 치험례 장수영 ,신현철 pp.121-128

항암화학요법과의 순차적, 그리고 병행적 요법으로서의 aRVS 투여로 장기 생존과 좋은 삶의 질을 유지한 전이성 비소세포폐암 증례보고 이진수 ,박형준 ,채진 ,김경석 ,정현식 ,이상헌 ,최원철 ,전성하 pp.129-135

재발성 음경지속발기증 1례 박성환 ,백선호 ,한수련 ,안영민 ,안세영 ,이병철 pp.136-143

체내에서 침이 발견된 사례 보고 양나래 ,김미경 ,최동준 ,한창호 pp.144-151

참고문헌 (25건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Inhibitory activity of euonymus alatus against alpha-glucosidase in vitro and in vivo 소장
2 Hwang JS, Kwon HK, Lee CK, Jeon WK, Ko BS, Im SH. Development of T Cell Immunomodulators from Natural Products. Research Focus on Natural Products and the Body's Immune and Inflammatory. 2007:253-73. 미소장
3 Ryu DS, Baek GO, Kim EY, Kim KH, Lee DS. Effects of polysaccharides derived from Orostachys japonicus A. Berger on induction of cell cycle arrest and apoptotic cell death in human colon cancer cells. BMB Rep. 2010; 43(11):750-5. 미소장
4 Membrane proteins and membrane proteomics. 네이버 미소장
5 Application of Proteomics and Protein Chip Analysis in the Diagnosis of Neurodegenerative Disorders 소장
6 [Application of genomics and proteomics in study of traditional Chinese medicine]. 네이버 미소장
7 Application of Proteomics in Chinese Medicine Research 네이버 미소장
8 Herbogenomics: from traditional Chinese medicine to novel therapeutics. 네이버 미소장
9 The role of traditional Chinese medicine in colorectal cancer treatment 네이버 미소장
10 Pinelliae Rhizoma Herbal-Acupuncture Solution Induced Apoptosis in Human Cervical Cancer Cells, SNU-17 네이버 미소장
11 Apoptotic B16-F1 cells coated with recombinant calreticulin mediated anti-tumor immune response in mice 네이버 미소장
12 The immunogenicity of tumor cell death. 네이버 미소장
13 Identification of Calreticulin as a Prognosis Marker and Angiogenic Regulator in Human Gastric Cancer 네이버 미소장
14 Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death. 네이버 미소장
15 Comparative proteomic analysis of paclitaxel sensitive A2780 epithelial ovarian cancer cell line and its resistant counterpart A2780TC1 by 2D-DIGE: the role of ERp57. 네이버 미소장
16 Nuclear proteome analysis of cisplatin-treated HeLa cells 네이버 미소장
17 Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is pyruvylated during 3-bromopyruvate mediated cancer cell death. 네이버 미소장
18 Anti-alpha-enolase autoantibodies are down-regulated in advanced cancer patients. 네이버 미소장
19 Ziprem Y, Nicole E. Willmarth, Jie Z, Sanjay K, Min W, Yang L, Peter AM, Andrew AQ, Michael PLi, Richard GP. MicroRNA 17/20 inhibits cellular inbasion and tumor metastasis in breast cancer by heterotypic signaling. Cell Biology. 2010;107(18):8231-36. 미소장
20 Protein Expression Profiling in the Spectrum of Renal Cell Carcinomas 네이버 미소장
21 Heterogeneous Nuclear Ribonucleoprotein A2 Is a Common Transcriptional Coactivator in the Nuclear Transcription Response to Mitochondrial Respiratory Stress 네이버 미소장
22 A Common Pathway for All Autoimmune Diseases? The Unholy Alliance of Environment, Cell Death and Nucleic Acids 네이버 미소장
23 Selective Association of Peroxiredoxin 1 with Genomic DNA and COX-2 Upstream Promoter Elements in Estrogen Receptor Negative Breast Cancer Cells 네이버 미소장
24 Prx1 enhances androgen receptor function in prostate cancer cells by increasing receptor affinity to dihydrotestosterone. 네이버 미소장
25 Joshi G, Aluise CD, Cole MP, Sultana R, Pierce WM, Vore M, St Clair DK, Butterfield DA. Alterations in brain antioxidant enzymes and redox proteomic identification of oxidized brain proteins induced by the anti-cancer drug adriamycin: implications for oxidative stress- mediated chemobrain. Neuroscience. 2010;166(3) :796-807. 미소장

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