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초록보기
Aim : Natural killer (NK) cells are cytotoxic lymphocytes that lyse certain tumor- and virus-infected cells without any prior stimulation or immunization. This article aims to review the significance of evaluating peripheral blood NK cells to predict anti-tumor immune function and prognosis in cancer patients.
Methods : PubMed was used to create a database for this review. Search words of cancer, natural killer cell, prognosis were used to retrieve related articles. References of the collected articles were also reviewed.
Results : Current evidence indicates that decreased or absent NK cell count or activity is mostly associated with the development or progression of cancer. In patients with various types of cancer, NK cell activity was mostly associated with the cancer prognosis and survival despite some conflicting results.
Conclusion : The data shows the evaluation of anti-tumor immunity in cancer patients through natural killer cell measurement still remains a controversial matter. However, it is clear that the NK cell activity plays an important role in cancer and is associated with prevention of both early stage and metastatic cancer.권호기사
참고문헌 (48건) : 자료제공( 네이버학술정보 )
| 번호 | 참고문헌 | 국회도서관 소장유무 |
|---|---|---|
| 1 | 홍원식 편저. 精校黃帝內經素問. 서울, 동양의학연구원출판사, p37-38, 55, 57, 78,82, 118-119, 122, 181, 213, 249, 256,304, 305, 319, 326, 347-348, 1981. | 미소장 |
| 2 | 조종관. 한방임상종양학. 대전, 주민출판사, p140, 2001. | 미소장 |
| 3 | An overview of current oriental medicine herbal cancer research in Korea  |
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| 4 | Integrative tumor board: a case report and discussion from East-West Cancer Center. |
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| 5 | 박재갑, 박찬일, 김노경. 종양학. 서울, 일조각, p227, 2009. | 미소장 |
| 6 | 이귀녕, 권오헌. 임상병리파일. 서울, 의학문화사, p347, 1045-1049, 1060-1066,1075-1081, 2003. | 미소장 |
| 7 | 烏山 一, 강호일 역. 면역학 일러스트 맵.서울, 월드사이언스, p52, 2009. | 미소장 |
| 8 | Abbas, A,K,, Lichtman, A,H,, 김각균 역.최신면역학입문 3판. 서울, 이퍼블릭, p34,2009. | 미소장 |
| 9 | Characteristics and uses of natural killer cells |
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| 10 | Biology of natural killer cells. |
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| 11 | Role of human natural killer cells in health and disease. |
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| 12 | 미생물 면역분과학회. 최신면역학. 서울,라이프사이언스, p14-15, 2011. | 미소장 |
| 13 | Isolation, phenotyping, and functional analysis of lymphocytes from human liver |
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| 14 | Lessons from T cell responses to virus induced tumours for cancer eradication in general. |
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| 15 | Breast cancer and the immune system. |
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| 16 | Natural cytotoxicity of peripheral blood lymphocytes and regional lymph node cells in breast cancer in women. |
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| 17 | Human breast cancer and impaired NK cell function. |
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| 18 | Correlation of stress factors with sustained depression of natural killer cell activity and predicted prognosis in patients with breast cancer. |
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| 19 | Relationship of natural killer cytotoxicity to clinical and biochemical parameters of primary human breast cancer. |
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| 20 | Competitive prognostic value of clinicopathologic and bioimmunologic factors in primary breast cancer. |
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| 21 | Cell mediated immune status in carcinoma breast. |
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| 22 | Immune changes in patients with advanced breast cancer undergoing chemotherapy with taxanes |
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| 23 | Relationship between natural killer cell activity and histological features of lymphocyte infiltration and partial regression of the primary tumor in melanoma patients. |
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| 24 | Effect of chemotherapy on natural-killer activity and antibody-dependent cell-mediated cytotoxicity in carcinoma of the lung. |
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| 25 | Prospective study of natural cytotoxicity in peripheral blood of patients with nonlymphoid solid malignancies |
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| 26 | Patterns of recurrence from head and neck cancer. An immunologic perspective. |
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| 27 | [Observation on natural killer cell activity in gastric cancer patients and effect of nonspecific immunopotentiator administration on its postoperative reduction]. |
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| 28 | Takeuchi, H,, Maehara, Y,, Tokunaga, E,, Koga, T,, Kakeji, Y,, Sugimachi, K. Prognostic significance of natural killer cell activity in patients with gastric carcinoma: a multivariate analysis. Am J Gastroenterol. 96(2):574-578, 2001. | 미소장 |
| 29 | The prognostic significance of intratumoral natural killer cells in patients with colorectal carcinoma |
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| 30 | The Influence of Host Response on Colorectal Cancer Prognosis |
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| 31 | Natural killer cell activity in patients with urologic cancer. |
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| 32 | Clinical Significance of Natural Killer Activity in Patients with Transitional Cell Carcinoma of the Bladder |
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| 33 | The prognostic value of peripheral blood lymphocyte subsets in patients with bladder carcinoma treated using neoadjuvant M‐VEC chemotherapy |
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| 34 | Natural killer cell activity in women at “high risk” for breast cancer, with and without benign breast syndrome |
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| 35 | Lytic effector cell activity and major depressive disorder in patients with breast cancer: a prospective study |
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| 36 | Natural killer cell activities of patients with breast cancer against different target cells. |
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| 37 | Hersey, P,, Edwards, A,, Milton, G,W,, McCarthy, W,H. No evidence for an association between natural killer cell activity and prognosis in melanoma patients. Nat Immun Cell Growth Regul. 3(2):87-94, 1983-1984. | 미소장 |
| 38 | The effect of surgery and chemotherapy on blood NK cell activity in patients with ovarian cancer. |
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| 39 | Circulating Lymphocyte Subsets in Patients with Lung Cancer and Their Prognostic Value |
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| 40 | 한국세포주은행 http://cancer.snu.ac.kr sub/catalog.php?CatNo=27 | 미소장 |
| 41 | The role of natural killer cells in human disease |
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| 42 | Immune cells in colorectal cancer: prognostic relevance and therapeutic strategies. |
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| 43 | Immunotherapy of malignant brain tumors |
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| 44 | Immunotherapy opportunities in ovarian cancer. |
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| 45 | Prognostic value of intratumoral natural killer cells in gastric carcinoma |
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| 46 | Takanami, I,, Takeuchi, K,, Giga, M. The prognostic value of natural killer cell infiltration in resected pulmonary adenocarcinoma. J Thorac Cardiovasc Surg. 121(6):1058-1063, 2001. | 미소장 |
| 47 | Prognostic significance of intratumoral natural killer cells in primary resected esophageal squamous cell carcinoma. |
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| 48 | Türkseven, M,R,, Oygür, T. Evaluation of natural killer cell defense in oral squamous cell carcinoma. Oral Oncol. 46(5):34-37, 2010. | 미소장 |
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