한국학술지인용색인(NRF)
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초록보기
본 연구에서는 3T3-L1 지방전구세포가 지방세포로 분화되는 과정에서 진피 에탄올 추출물(ethanol extracts of citrus peel, EECP)이 유발하는 항비만 효능에 대해서 조사하였다. 3T3-L1 세포의 생존율 및 증식에 영향을 미치지 않는 농도의 EECP를 처리하였을 경우 지방세포에서 특징적으로 나타나는 lipid droplet의 형성과 triglyceride의 생성도 억제되는 것으로 나타났다. EECP가 유발하는 지방세포로의 분화억제에는 PPARγ, C/EBPα, C/EBPβ 및 SREBP-1c 등과 같은 adipogenic transcription factors의 발현억제가 관여하는 것으로 나타났으며, 그 결과로 aP2 및 Leptin과 같은 adipocyte expressed genes의 발현도 억제되는 것으로 조사되었다. 또한 EECP는 AMPK 및 ACC의 인산화를 유발하였으며, AMPK 억제제인 Compound C를 이용하여 AMPK의 활성을 억제하였을 경우 EECP에 의한 AMPK의 인산화와 adipogenic transcription factors의 억제현상이 회복되었다. 이상의 결과에서 EECP는 AMPK signaling pathway를 통하여 항비만 효능을 가진다는 것을 알 수 있었으며, 향후 비만 예방 및 억제와 관련된 기능성 소재로서의 진피의 활용 가능성을 제시한 것으로서 그 가치가 매우 높을 것으로 생각된다.
Citrus peel (CP) is used as a traditional herb with diverse beneficial pharmacological activities, such as anti-inflammatory, anti-oxidant, and anti-allergic effects. However, the anti-obesity effects of citrus peel are poorly defined. The aim of this study was to evaluate ethanol extracts of citrus peel (EECP) for its adipocyte differentiation and adipogenesis in 3T3-L1 preadipocytes. The aim of this study was to evaluate an EECP for its adipocyte differentiation and adipogenesis in 3T3-L1 preadipocytes. Treatment with EECP significantly suppressed the terminal differentiation of 3T3-L1 preadipocytes in a dose-dependent manner, as confirmed by a decrease in lipid droplet number and lipid content and an accumulation of cellular triglyceride. EECP exhibited potential adipogenesis inhibition and down- regulated the expression of pro-adipogenic transcription factors, such as sterol regulatory element- binding protein-1c (SREBP-1c), peroxisome proliferator-activated receptor-γ (PPARγ), CCAAT/enhancer- binding proteins α (C/EBPα) and C/EBPβ, and adipocyte expressed genes, such as adipocyte fatty acid binding protein (aP2) and Leptin. In addition, EECP treatment effectively activated the AMP-activated protein kinase (AMPK) signaling pathway; however, compound C, a specific inhibitor of AMPK, significantly reduced the EECP-induced inhibition of adipogenesis. Taken together, these results indicate EECP showed strong anti-obesity effects through the AMPK signaling pathway, and further studies will be needed to identify the active compounds that confer the anti-obesity activity of EECP.
Citrus peel (CP) is used as a traditional herb with diverse beneficial pharmacological activities, such as anti-inflammatory, anti-oxidant, and anti-allergic effects. However, the anti-obesity effects of citrus peel are poorly defined. The aim of this study was to evaluate ethanol extracts of citrus peel (EECP) for its adipocyte differentiation and adipogenesis in 3T3-L1 preadipocytes. The aim of this study was to evaluate an EECP for its adipocyte differentiation and adipogenesis in 3T3-L1 preadipocytes. Treatment with EECP significantly suppressed the terminal differentiation of 3T3-L1 preadipocytes in a dose-dependent manner, as confirmed by a decrease in lipid droplet number and lipid content and an accumulation of cellular triglyceride. EECP exhibited potential adipogenesis inhibition and down- regulated the expression of pro-adipogenic transcription factors, such as sterol regulatory element- binding protein-1c (SREBP-1c), peroxisome proliferator-activated receptor-γ (PPARγ), CCAAT/enhancer- binding proteins α (C/EBPα) and C/EBPβ, and adipocyte expressed genes, such as adipocyte fatty acid binding protein (aP2) and Leptin. In addition, EECP treatment effectively activated the AMP-activated protein kinase (AMPK) signaling pathway; however, compound C, a specific inhibitor of AMPK, significantly reduced the EECP-induced inhibition of adipogenesis. Taken together, these results indicate EECP showed strong anti-obesity effects through the AMPK signaling pathway, and further studies will be needed to identify the active compounds that confer the anti-obesity activity of EECP.
권호기사
참고문헌 (36건) : 자료제공( 네이버학술정보 )
| 번호 | 참고문헌 | 국회도서관 소장유무 |
|---|---|---|
| 1 | Effects of leptin on apoptosis and adipogenesis in 3T3-L1 adipocytes  |
미소장 |
| 2 | Changes in the phospholipid fatty acid composition of the lipid droplet during the differentiation of 3T3-L1 adipocytes |
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| 3 | Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. |
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| 4 | Chen, H. C., and Farese, R. V. Jr. (2000). DGAT and triglyceride synthesis: a new target for obesity treatment? Trends Cardiovasc. Med, 10, 188-192. | 미소장 |
| 5 | AMPK activation regulates apoptosis, adipogenesis, and lipolysis by eIF2alpha in adipocytes. |
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| 6 | Functions of AMP‐activated protein kinase in adipose tissue |
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| 7 | The citrus flavonoids hesperidin and naringin do not affect serum cholesterol in moderately hypercholesterolemic men and women. |
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| 8 | Trans-10,cis-12 conjugated linoleic acid reduces triglyceride content while differentially affecting peroxisome proliferator activated receptor gamma2 and aP2 expression in 3T3-L1 preadipocytes. |
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| 9 | Activation and signaling by the AMP-activated protein kinase in endothelial cells. |
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| 10 | The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation. |
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| 11 | Adipose tissue as an endocrine organ |
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| 12 | Developmental Origin of Fat: Tracking Obesity to Its Source |
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| 13 | Triglyceride: one molecule at the center of health and disease. |
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| 14 | Balancing Cellular Energy |
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| 15 | Effect of heat treatment on the antioxidant activity of extracts from citrus peels. |
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| 16 | Autophagy regulates lipolysis and cell survival through lipid droplet degradation in androgen-sensitive prostate cancer cells. |
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| 17 | AMPK control of myocardial fatty acid metabolism fluctuates with the intensity of insulin-deficient diabetes |
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| 18 | Effect of Different Part of Mandarin Intake on Antioxidative Capacity in 15-month-old Rats | 소장 |
| 19 | ADD1/SREBP1 Activates PPARγ through the Production of Endogenous Ligand |
미소장 |
| 20 | Le Lay, S., and Dugail, I. (2009), "Connecting lipid droplet biology and the metabolic syndrome", Prog. Lipid Res, 48, 191-195. | 미소장 |
| 21 | Suppressive actions of eicosapentaenoic acid on lipid droplet formation in 3T3-L1 adipocytes |
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| 22 | Inhibitory effect of (-)-epigallocatechin-3-gallate on lipid accumulation of 3T3-L1 cells. |
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| 23 | Obesity and Colorectal Cancer | 소장 |
| 24 | Clinical Guidelines of Treatment of Obesity in Adults | 소장 |
| 25 | Global nutrition transition and the pandemic of obesity in developing countries. |
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| 26 | Exaggerated replication in culture of adipocyte precursors from massively obese persons |
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| 27 | The potential for strategies using micronutrients and heterocyclic drugs to treat invasive gliomas |
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| 28 | Ca2+/calmodulin-dependent protein kinase kinase is involved in AMP-activated protein kinase activation by alpha-lipoic acid in C2C12 myotubes. |
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| 29 | Functional analysis of unfermented and fermented citrus peels and physical properties of citrus peel-added doughs for bread making |
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| 30 | Obesity and the Regulation of Energy Balance |
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| 31 | Vázquez-Vela, M. E., Torres, N., and Tovar, A. R. (2008), "White adipose tissue as endocrine organ and its role in obesity", Arch. Med. Res, 39, 715-728. | 미소장 |
| 32 | Xu, X. J., Valentine, R. J., and Ruderman, N. B. (2014), "AMP-activated Protein Kinase (AMPK): Does this master regulator of cellular energy state distinguish insulin sensitive from isulin resistant obesity? Curr", Obes. Rep, 3, 248-255. | 미소장 |
| 33 | Beta-very low density lipoprotein induces triglyceride accumulation through receptor mediated endocytotic pathway in 3T3-L1 adipocytes. |
미소장 |
| 34 | Isolation of the Anti-tumor Promoters from Citrus Peels | 소장 |
| 35 | Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor alpha. |
미소장 |
| 36 | Structure of the LKB1-STRAD-MO25 Complex Reveals an Allosteric Mechanism of Kinase Activation |
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