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Objectives : Laver (Porphyra tenera), a red algae species, is one of the most widely consumed edible seaweed in Korea. Laver contains various substances such as essential amino acid, fiber, minerals and polyphenols that benefit human health. In the present study, we prepared ethanol extracts from commercially processed product of Porphyra tenera, and evaluated the growth inhibitory effect against human oral squamous carcinoma YD-10B cells.

Methods : Cell viability was measured by MTT assay. Apoptosis was confirmed by TUNEL assay and flow cytometry with the green fluorescent dye FITC annexin V entering apoptotic cells and the red fluorescent dye PI not entering. The expression of the relevant proteins was detected using Western blot.

Results : Ethanol extracts of Porphyra tenera (PTE, 50-200 ㎍/㎖) caused a significant decrease of cell viability in a dose dependant manner. The cell death occurred as a result of apoptotic process as determined by TUNEL assay and flow cytometric analysis. In line with this observation, decrease in procaspase proteins and increase in cytosolic cytochrome c were observed in cells treated with PTE. In addition, exposure to PTE decreased the expression levels of Bcl-2, and induced PARP cleavage and AIF translocation from mitochondria to nucleus.

Conclusions : In conclusion, PTE exerts anti-cancer effects by inducing apoptosis via caspase activation and AIF nuclear translocation in YD-10B cells. These results provide evidence for the possible therapeutic effect of Porphyra tenera in oral cancer cells.

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참고문헌 (25건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 [Nutritional evaluation and physiological effects of edible seaweeds]. 네이버 미소장
2 The korean association of university professors of herbology. Herbology. Seoul : Younglimsa. 1992 :471-4, 511-4. 미소장
3 Park CK, Kang TJ. The nutritional and functional constituents of laver. Bull Fish Sci Inst Yosu Nat'l Univ. 2000 ; 9 : 133-7. 미소장
4 Analysis of Biochemical Compositions and Nutritive Values of Six Species of Seaweeds 소장
5 A Study on the Development of High-fiber supplements for the Diabetic Patients -Effect of Seaweed Supplementation on the Lipid and Glucose Metabolism in Streptozotocin-induced Diabetic Rats- 네이버 미소장
6 The Effect of Porphyra tenera Extract on Serum Lipid Content in Ovariectomized Rats 소장
7 Effect of Natural Plant Components on the Nitrite-scavenging 네이버 미소장
8 Effect of Natural Foods on the Inhibition of N-Nitrosodimethylamine Formation 네이버 미소장
9 Effects of Porphyra tenera Extracts on Formation of Collagen Cross - link in Ovariectomized Rats 소장
10 Antimicrobial activities of ethanolic extracts of marine resources against Propionibacterium acnes 소장
11 Hong YK, Park IS, Jung YH, Song SH, Hong SY. Effect of the seaweed porphyra yezoensis extract on triton WR-1339 induced hypercholesterolemia in mouse. J Korean Fish Soc. 1998 ; 31(4) :508-15. 미소장
12 The Correlation of Antioxidative Effects of 5 Korean Common Edible Seaweeds and Total Polyphenol Content 소장
13 Effect of Porphyran Isolated from Laver, Porphyra yezoensis on Calcium, Magnesium and Potassium Contents in Hyperlipidemic Rats 소장
14 Clinical Diagnosis of Oral Cancer 소장
15 Kerr JF, Winterford CM, Harmon BV. Apoptosis. Its significance in cancer and cancer therapy. Cancer. 1994 ; 73(8) : 2013-26. 미소장
16 Expression of Apoptosis Related Genes from HaCaT Cell after UVB Irradiation 소장
17 Herbal medicine as inducers of apoptosis in cancer treatment. 네이버 미소장
18 Studies on the Anti-cancer Effect and the Mechanism of Apoptosis by Baekduong-tang in Human Colon Cancer Cell Line HCT-116 소장
19 Caspases: the executioners of apoptosis. 네이버 미소장
20 Role of Bcl-2 family proteins and caspases in the regulation of apoptosis 네이버 미소장
21 Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. 네이버 미소장
22 Boulares AH, Yakovlev AG, Ivanova V, Stoica BA, Wang G, Iyer S, Smulson M. Role of poly (ADP-ribose) polymerase (PARP) cleavage in apoptosis. Caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells. J Bio Chem. 1999 ; 274(33) : 22932-40. 미소장
23 Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. 네이버 미소장
24 Apoptosis inducing factor (AIF): a phylogenetically old, caspase-independent effector of cell death 네이버 미소장
25 Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor 네이버 미소장

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