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국회도서관 홈으로 정보검색 소장정보 검색

초록보기

Objective : Impaired response inhibition has been suggested to play an important role in the pathophysiology of obsessive-compulsive disorder (OCD). The aim of this study was to evaluate the response inhibition in patients with OCD, by using the Go/NoGo paradigm, and to better understand its associations with clinical symptoms.

Methods : The participants included 63 OCD patients and 80 healthy volunteers matched in age and sex. response inhibition was evaluated using computerized Go/NoGo task, in which their commission error rates, omission error rates, and mean response times were measured. The severity of clinical symptoms in the OCD patients was assessed using Montgomery-Asberg Depression Scale and Yale-Brown Obsessive Compulsive Scale.

Result : OCD patients showed significantly impaired inhibition and higher omission errors rates despite their slower response time, compared to normal controls. Clinical symptoms were not correlated with commission errors and omission errors.

Conclusion : The present results indicate that impairment in response inhibition may play a critical role in the pathophysiology of OCD as a trait. These findings suggest that deficit of response inhibition may contribute to developing and maintaining clinical symptoms such as compelling need to repeat certain actions in patients with OCD.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
우울증 자살시도자들에서 표준우울평가척도들의 요인분석 : CRESCEND 연구 홍민아, 김민경, 김정범, 전태연, 임현우, 이민수, 김재민 pp.3-11
성폭력 피해자에서 MMPI 특성 김정현, 도진아, 최인철, 임명호 pp.12-18
성적 노출증 및 접촉도착증의 유병율 및 임상특성 : 예비연구 박선화, 권석현, 왕태종, 홍정민, 김은비, 맹정원, 임명호 pp.19-25
도시거주 결혼이민여성의 정신건강 현황과 영향 요인 박수빈, 용효중, 홍진표 pp.26-32
강박장애 환자의 반응억제 결함 부영준, 김세주, 강지인 pp.33-37
직무스트레스와 우울 및 불안 증상의 연관성 김윤신, 김은진, 임세원, 신동원, 오강섭, 신영철 pp.38-46
범불안장애 환자와 일반인의 걱정 내용 및 심각도의 비교 김휘곤, 김대호, 오대영, 서호준, 허휴정, 채정호 pp.47-53
북한어판 CES-D(Center for Epidemiologic Studies Depression Scale-North Korea ; CES-D-NK)의 신뢰도와 타당도 박승진, 이소희, 전진용, 이태엽, 한정미, 안명희, 홍진표 pp.54-60
경찰공무원에서 외상후스트레스장애와 기질 및 성격 특성의 관계 이정현, 김옥주, 남윤영, 신정하, 이희봉, 김지애, 심민영 pp.61-68
우울장애가 있는 독거노인에 대한 긍정심리 집단치료의 효과 이승원, 하주원, 김현수, 이지희, 이주영, 이정애, 오강섭 pp.69-74

참고문헌 (25건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Ting JT, Feng G. Neurobiology of obsessive-compulsive disorder: insights into neural circuitry dysfunction through mouse genetics. Curr Opin Neurobiol. 2011;21:842-848. 미소장
2 Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: The orbitofronto-striatal model revisited 네이버 미소장
3 Orbitofrontal Dysfunction in Patients with Obsessive-Compulsive Disorder and Their Unaffected Relatives 네이버 미소장
4 Repeated Cortico-Striatal Stimulation Generates Persistent OCD-Like Behavior 네이버 미소장
5 Inhibition and impulsivity: Behavioral and neural basis of response control 네이버 미소장
6 Neuropsychological function in obsessive-compulsive disorder: effects of comorbid conditions on task performance 네이버 미소장
7 Bannon S, Gonsalvez CJ, Croft RJ, Boyce PM. Response inhibition deficits in obsessive-compulsive disorder. Psychiatry Res. 2002;110: 165-174. 미소장
8 Motor inhibition in trichotillomania and obsessive–compulsive disorder 네이버 미소장
9 First MB. User’s guide for the structured clinical interview for DSM-IV-TR axis I disorders: SCID-I;2002. 미소장
10 Impaired response inhibition in obsessive compulsive disorder 네이버 미소장
11 Mapping Motor Inhibition: Conjunctive Brain Activations across Different Versions of Go/No-Go and Stop Tasks 네이버 미소장
12 Neuropsychological analyses of impulsiveness in childhood hyperactivity. 네이버 미소장
13 Long-term test-retest reliability of the P3 NoGo wave and two independent components decomposed from the P3 NoGo wave in a visual Go/NoGo task 네이버 미소장
14 The effects of exposure to traumatic stressors on inhibitory control in police officers: A dense electrode array study using a Go/NoGo continuous performance task 네이버 미소장
15 The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability. 네이버 미소장
16 A new depression scale designed to be sensitive to change. 네이버 미소장
17 Neurocognitive endophenotypes of obsessive-compulsive disorder 네이버 미소장
18 Motor inhibition and cognitive flexibility in obsessive-compulsive disorder and trichotillomania. 네이버 미소장
19 Abnormal visual event-related potentials in obsessive-compulsive disorder without panic disorder or depression comorbidity 네이버 미소장
20 Discrepant target detection and action monitoring in obsessive-compulsive disorder. 네이버 미소장
21 Reduced response-inhibition in obsessive–compulsive disorder measured with topographic evoked potential mapping 네이버 미소장
22 Electrophysiological correlates of behavioral response inhibition in patients with obsessive–compulsive disorder 네이버 미소장
23 Hoarding disorder and obsessive–compulsive disorder show different patterns of neural activity during response inhibition 네이버 미소장
24 Go - No Go Learning After Frontal Lobe Lesions in Humans 네이버 미소장
25 Attentional control and subjective executive function in treatment-naive adults with Attention Deficit Hyperactivity Disorder. 네이버 미소장