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Objectives : The aim of this study is to investigate cell viability, anti-inflammatory, antioxidant, immuno-enhancing activity using various extracts of Yeonsan Ogye.

Methods : In order to evaluate cytotoxicity, MTT assay was performed. We investigated production levels of pro-inflammatory cytokines such as tumor necrosis factor (TNF)-α and interleukin (IL)-6, and nitric oxide(NO) in LPS-induced RAW 264.7 cells. NO production in RAW 264.7 cells was measured by using Griess reagent. Cytokines including IL-6 and TNF-α were measured by Luminex and ROS was measured by Flow cytometry.

Results : No cytotoxicity of various extracts of Yeonsan Ogye was observed in RAW 264.7 cells. Productions of ROS in RAW 264.7 cells were increased from extraction of bones and decreased from extraction of skin. Also, productions of NO in RAW 264.7 cells were increased to bone extract and decreased at skin extract. In addition, productions of pro-inflammatory cytokines (IL-6 and TNF-α) in LPS-induced RAW 264.7 cells were decreased at skin, meat extracts, respectively. Finally, the levels of immune-related cytokines (IL-6 and TNF-α) were increased compared to those of the normal group.

Conclusions : It is concluded that Yeonsan Ogye extracts seem to have significant biological activities likes anti-inflammatory, antioxidant, immuno-enhancing etc. These results may be developed as a raw material for new health food and new therapeutics to ease the symptoms related with inflammatory and oxidative stress. In terms of oriental traditional medicine, we expect that it contribute to building of EBM (Evidence-Based Medicine) from the this result.

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기사명 저자명 페이지 원문 목차
半夏白朮天麻湯加味方을 이용한 眩暈 치험2例 = (A)clinical study of two patients on vertigo with Banhabaekchulcheonma-tang gamibang 구진숙, 김봉현, 서부일 pp.1-6
한의사들의 천연물 신약 처방의사에 관한 연구 = (A)Study on Prescription Intention of Botanical Drug in Korean Medicine Doctors 권용찬, 빈성오, 구진숙, 서부일 pp.7-13
통현이팔단 에탄올 추출물의 Methicillin Resistant Staphylococcus aureus에 대한 항균활성 = Antibacterial activity of Tonghyeonipal-dan against Methicillin-resistant Staphylococcus aureus 김인원, 강옥화, 공룡, 권동렬 pp.15-21
동의보감에 수재된 烏鷄에 대한 생리활성 연구 = (The)Study on Biological Activities of Yeonsan Ogye listed on Dong-ui-bo-gam 김진우, 심부용, 최학주, 이해진, 김동희 pp.23-28
薄荷의 국내·외 연구동향과『본초학』, 한국표준질병사인분류의 상관관계에 대한 연구 = (The)Literature Study of Research Trend of Menthae Herba and Relationship Between the Herbology and KCD-code 김현석, 정종길, 이숭인 pp.29-43
糯草 에탄올추출물이 Human 유래 Jurkat 세포와 THP-1 세포의 알러지 및 염증 사이토카인에 미치는 영향 = Effect of 'DaoCao' on the inflammatory cytokines in Human Jurkat cell and THP-1 cell 이영근, 김청택, 노성수, 최학주 pp.45-49
한약재 복합 추출물의 항산화, 항균 및 항염 효과 = Antioxidant, Antimicrobial and Anti-inflammatory of Mixed Medicinal Herb Extract 이인철, 김미경 pp.51-58
대두, 홍삼, 진피로 구성된 발효 추출물의 항염증 효능에 관한 연구 = Anti-inflammatory effects of the fermentation extracts consisting of soybean, red ginseng and Citrus Unshiu Peel 이종록, 김영우, 변성희, 김상찬, 박숙자 pp.59-65
해독금화산 물추출물이 LPS로 유도된 대식세포의 염증반응에 미치는 영향 = Effects of Haedokgumhwa-san Water Extracts on LPS-induced Inflammatory Response in Macrophage 임재수, 강옥화, 서윤수, 권동렬 pp.67-74
동북아 4개국 약전의 한약제제 비교분석 = Comparative analysis of herbal formulas in Pharmacopoeia of 4 countries in Northeast Asia 장진호, 이해니, 김지훈, 김윤경 pp.75-83

참고문헌 (20건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
1 Oh JH. HF-IFF: Applying TF-IDF to Measure Symptom-Medicinal Herb Relevancy and Visualize Medicinal Herb Characteristics -Studying Formulations in Cheongkangeuigam-. Kor J Herbol. 2015 ; 30(3): 63-8. 미소장
2 Cultural Heritage Administration. Natural heritage Division. http://www.cha.go.kr/korea/heritage/search /Culresult_Db_View.jsp?mc=NS_04_03_01&VdkVgwK ey=16,02650000,34. 미소장
3 Heo J. DongEuiBoGam. Seoul : BubInBooks. 2007 :1065, 1858-9. 미소장
4 Chae HS, Ahn CN, Yoo YM, Ham JS, Lee JM, Yoon SK, Choi YI. The Effects of the High Pressure Boiled Extracts (HPBE) of the Ogol Chicken with Herbs on the Hormones, Cytokine, Specific Antibody of Serum in the Rat. Korean J Food Sci Anim Res. 2004 ; 24(3) : 283-92. 미소장
5 Choi BK, Jung SY, Park KS, Jo JH. Reactive Oxygen Substances and Diseases. Seoul : SinIlBooks. 2004 : 34-7. 미소장
6 Effect of buchu (Allium tuberosum) on lipid peroxidation and antioxidative defense system in streptozotocin-induced diabetic rats 소장
7 Park SM. Effect of Natural Products on Skin Cells -Action and Suppression of Reactive Oxygen Species-. Soc Cosmet Sci Korea. 1999 ; 32(10) : 77-127. 미소장
8 Kwon HG, Hwang JS, So JS, Lim SH. Immunological homeostasis and inflammatory immune disorders. Korean Soc Mol Cell Biol. 2008 ; 20(1) : 48-69. 미소장
9 Chronic inflammation: importance of NOD2 and NALP3 in interleukin‐1β generation 네이버 미소장
10 Byun SH, Yang CH, Kim SC. Inhibitory effect of Scrophulariae Radix extract on TNF-α, IL-1β, IL-6and nitric oxide production in lipopolysaccharide activated Raw 264.7 cells. Kor J Herbol. 2005 ;20(2) : 7-16. 미소장
11 Chung HT, Pae HO, Choi BM, Billiar TR, Kim YM. Nitric oxide as a bioregulator of apoptosis. Biochem Biophys Res Commun. 2001 ; 282(5) :1075-9. 미소장
12 Han HS. Effect of Fermented Artemisiae Argyi Folium on Human Hepatoma Cell Line HepG2Activity. Kor J Herbol. 2013 ; 28(3) : 107-13. 미소장
13 Tak MJ, Tak MR, Kang KH, Ko WS, Yoon HJ. The Inhibitory Effects of Yang Geouk San Hwa-Tang on LPS-stimulated inflammation in RAW264.7macrophage cells. J Korean Orient Med Ophthalmol Otolaryngol Dermatol. 2010 ; 23(1) : 118-34. 미소장
14 Interleukin-6 and chronic inflammation. 네이버 미소장
15 In vitro Antioxidant and Anti-inflammatory Effects of Ethanol Extracts from Sprout of Evening Primrose (Oenothera laciniata) and Gooseberry (Actinidia arguta) 소장
16 Neutrophil Recruitment by Tumor Necrosis Factor from Mast Cells in Immune Complex Peritonitis 네이버 미소장
17 Effect of osteoprotegerin in combination with interleukin-6 on inhibition of osteoclast differentiation 네이버 미소장
18 Origin and physiological roles of inflammation. 네이버 미소장
19 Jung SY, Seo HS. The Effects of Samhwangseje on Anti-Inflammation in Raw 264.7 cell. J Korean Orient Med Ophthalmol Otolaryngol Dermatol. 2009 ; 22(1) : 108-19. 미소장
20 Cha JH, Kim YS, Lee EM. Effects of Prunellae spica water extract on immune response in macrophage cells. J Orien Obstet Gynecol 2010 ; 23(1) : 91-100. 미소장

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