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Objectives : The aim of this study is to investigate anti-inflammatory activity using various extracts of rice straw (DaoCao) extract (RS).

Methods : To investigate the anti-inflammatory effect of RS, we examined the effect of RS on cytokines production on THP-1 cell. Cells were cultured in incubator (37℃, CO2 5%, 0.5% FBS-RPMI, 1X106 cells/ml). One hour after, Dermatophagoides pteronissinus (Dp., 10 ug/ml) was treated into cell and at 6 hour after, each different concentrations(0.1, 1 and 10 ug/ml) of RS were treated. The cells were incubated for 16 hours and harvest the supernatant. The levels of IL-4, IL-5, IL-6, IL-8, MCP-1 and TNF-αwere determined using a commercially available ELISA kit.

Results : We investigated whether RS has the inhibition of inflammatory response in Jurkat cells and THP-1 cells. RS suppressed secretion of IL-4, IL-5, and TNF-α induced by house dust mites in Jurkat cells. It showed significant effects for all concentrations. RS suppressed the increased expression of IL-6, IL-8 and MCP-1 after treatment with mite in THP-1 cells. These results suggest that RS may be used as a valuable agent for treating allergic diseases such as atopy due to its anti-inflammatory property.

Conclusions : RS showed significant biological activities with anti-inflammatory in the human T cells. These results suggest that RS may be used as a valuable agent for treating allergic diseases such as atopy due to its anti-inflammatory property. In terms of Korean traditional medicine, we expect the results to contribute to building of EBM (Evidence-Based Medicine).

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기사명 저자명 페이지 원문 목차
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참고문헌 (21건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 HC. Park, Kim YH, Kim JE, Ko JY, Namgoung SJ, Lee CM, Kim YS, Ro YS. Effect of air purifier on indoor air quality and atopic dermatitis. Allergy Asthma Respir Dis. 2013 ; 1(3) : 248-56. 미소장
2 Kim JH. Allergy Asthma & Respiratory Disease Allergy Asthma & Respiratory Disease. 2004 ; 14(1): 12-23. 미소장
3 Conformational stability of B cell epitopes on group I and group II Dermatophagoides spp. allergens. Effect of thermal and chemical denaturation on the binding of murine IgG and human IgE antibodies. 네이버 미소장
4 The presence of IgE on macrophages and dendritic cells infiltrating into the skin lesion of atopic dermatitis 네이버 미소장
5 Guidelines for management of atopic dermatitis. 네이버 미소장
6 Pictorial keys for the identification of domestic mites. 네이버 미소장
7 Induction of atopic dermatitis by inhalation of house dust mite 네이버 미소장
8 The role of contact allergy to aeroallergens in atopic dermatitis. 네이버 미소장
9 Zhonghuabencaobianjiwei. Zhonghuabencao. Shanghai : Shanghaikexuejishuchubanshe. 2002 : 381. 미소장
10 ( Inhibitory Effect of Gamigunggui-tang on Allergic Contact Dermatitis ) 소장
11 House dust mite, Dermatophagoides pteronissinus increases expression of MCP-1, IL-6, and IL-8 in human monocytic THP-1 cells 네이버 미소장
12 Kim IS, Kim EH, Kim DH, Kim JS, Lee JS. Effect of House Dust Mite and CCL2 on S100A8 and S100A9 Expression in Human Monocytes. Biomed Sci Lett. 2013 ; 19(4) : 344-7. 미소장
13 Jung JY, Jung HA. Effect of Phellinus igniarius Quel Extract on the Anti-inflammatory, Anti allergy, Anti-oxidant, Anti-wrinkle reaction. J Korean Orient Med Ophthalmol Otolaryngol Dermatol. 2010 ;23(3) : 42-65. 미소장
14 IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice 네이버 미소장
15 Yazdanbakhsh M, van den Biggelaar A, Maizels RM. Th2 responses without atopy: immuno- regulation in chronic helminth infections and reduced allergic disease. Trends Immunol. 2001 ; 22(7) : 372–7. 미소장
16 Nuttall TJ, Hill PB, Bensignor E, Willemse T House dust and forage mite allergens and their role in human and canine atopic dermatitis. Vet Dermatol. 2006 ; 17(4) : 223-35. 미소장
17 Park JM, Chae JW. Effects of Rice Straw (RS) on Allergic Contact Dermatitis (ACD) Induced by DNCB in Mice. J Pediatr Korean Med. 2013 ; 27(4) 39-49. 미소장
18 Sato IN. Stuffy nose of hay fever was completely healed in fermented rice straw. Modern agriculture. 2009 : 284-5. 미소장
19 Regulation of immune tolerance by anti-inflammatory neuropeptides. 네이버 미소장
20 The Concept of Type-1 and Type-2 Helper T Cells and Their Cytokines in Humans 네이버 미소장
21 Relevant B cell epitopes in allergic disease. 네이버 미소장

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