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22대 대한민국 국회 국회정보길라잡이 국회의원검색
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Objectives : Fermentation of herbs has been known to be helpful in improving the immune systems and protecting body against disease. The present study was conducted to evaluate anti-inflammatory effects of the fermentation extracts (FE) consisting of soybean, red ginseng and Citrus Unshiu Peel in lipopolysaccharide (LPS)-activated Raw264.7 cells.

Methods : FE were prepared by the fermentation with Bacillus Subtilis and then by extraction with ethanol (95%; prepared by the fermentation process). Cell viability was measured by MTT assay. Nitric oxide (NO) production was measured in culture media by Griess assay. The expression of nuclear factor (NF)-κB and inhibitory kappa B alpha (IκBα) was determined by Western blot.

Results : LPS-induced production of NO and PGE2 was dose-dependently decreased by the treatment of FE in Raw264.7 cells. These suppressive effects of FE on NO and PGE2 production were related to the inhibition of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression. FE inhibited LPS-induced production of pro-inflammatory cytokines, TNF-α, IL-6, and IL-1β in a dose-dependent manner. Furthermore, FE inhibited the NF-κB signaling pathway through the prevention of LPS-induced degradation of IκBα in cytosol and the nuclear translocation of NF-κB.

Conclusions : These findings suggest that FE could have anti-inflammatory effects on LPS-induced inflammatory responses in macrophages.

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半夏白朮天麻湯加味方을 이용한 眩暈 치험2例 = (A)clinical study of two patients on vertigo with Banhabaekchulcheonma-tang gamibang 구진숙, 김봉현, 서부일 pp.1-6
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참고문헌 (38건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
1 Inflammation in Peripheral Artery Disease 네이버 미소장
2 Nitric oxide and macrophage function. 네이버 미소장
3 Chemokines, inflammation and the immune system. 네이버 미소장
4 The advent of the cytokine storm. 네이버 미소장
5 Negative Regulators of Toll-like Receptor 4-Mediated Macrophage Inflammatory Response 네이버 미소장
6 PGE(2) suppression of innate immunity during mucosal bacterial infection. 네이버 미소장
7 Immunity, Inflammation, and Allergy in the Gut 네이버 미소장
8 New insights into atopic dermatitis. 네이버 미소장
9 Increased health functionality of fermented foods 소장
10 Research trends of fermented medicinal herbs 소장
11 Total flavonoids and phenolics in fermented soy products and their effects on antioxidant activities determined by different assays. 소장
12 Son JH, Ha BJ. Antioxidative and antiaging effects of fermented soybean, rice bran, and red ginseng by mixed ratios. J Fd Hyg Safety. 2013 ; 28(4) :354-9. 미소장
13 Fractionation of Angiotensin Converting Enzyme(ACE) Inhibitory Peptides from Soybean Paste 소장
14 Nam EY, Kim DI, Choi MS, Kim HJ. Effects of fermented soybean on body weight, body fat and serum lipid in obese women. J Korean Obstet Gynecol. 2015 ; 28(1) : 58-72. 미소장
15 Professors of herbalogy, Colleges of Korean medicine in Korea. Herbalogy. Seoul : Younglimsa. 2010 :194-5. 미소장
16 Park CD, Jung HK, Park CH, Jung YS, Hong JH, Ko HS, Kang DH, Kim HS. Isolation of citrus peel flavonoid bioconversion microorganism and inhibitory effect on the oxidative dDamage in pancreatic beta cells. KSBB J. 2012 ; 27 : 67-74. 미소장
17 Preparation and Quality Characteristics of the Fermentation product of Ginseng by Lactic Acid Bacteria (FGL) 소장
18 Metabolism of Ginsenosides to Bioactive Compounds by Intestinal Microflora and Its Industrial Application 소장
19 Trinh HT, Han SJ, Kim SW, Lee YC, Kim DH. Bifidus fermentation increases hypolipidemic and hypoglycemic effects of red ginseng. J Microbiol Biotechnol. 2007 ; 17 : 1127-33. 미소장
20 Kim TY. Method for preparing new protein having fungtion and anticancer effects. Korea patent. 2011: number 10-1144471. 미소장
21 The use of the MTT assay to study drug resistance in fresh tumour samples. 네이버 미소장
22 Lee S, Son J, Sohn J, Kim W, Lee S, Lee PJ, Leem K. Effects of herbal composition and fermented Cervi Pantotrichum Cornu on longitudinal bone growth in adolescent male rats. Kor J Herbol. 2009 ; 24(1): 121-31. 미소장
23 Liu RL, Ren SF, Wang YZ. Influence of the fermentation Cordyceps sinensisfy powder on blood uric acid and lipid in the cases of essential hypertension. World Clin Drugs. 2006 ; 27 :498-502. 미소장
24 Effect of the New Diabetic Formula on Streptozotocin-induced Diabetic Rats 소장
25 Kim DG, Kim MB, Kim H, Park JH, Lim JP, Hong SH. Herb Medicinal Pharmacognosy. Seoul :Shinilbooks. 2005 : 231-2. 미소장
26 Heo J. Donguibogam. Seoul : Namsandang. 2004: 81. 미소장
27 The immune system in aging: roles of cytokines, T cells and NK cells. 네이버 미소장
28 Tumor necrosis factor 네이버 미소장
29 Cassim B, Mody G, Bhoola K. Kallikrein cascade and cytokines in inflamed joints. Pharmacol Ther. 2002 ; 94 : 1-34. 미소장
30 NFκB: a promising target for natural products in cancer chemoprevention 네이버 미소장
31 NF-κB regulation in the immune system 네이버 미소장
32 Magnani M, Crinelli R, Bianchi M, Antonelli A. The ubiquitin-dependent proteolytic system and other potential targets for the modulation of nuclear factor-κB (NF-κB). Curr Drug Targets. 2000 ; 1: 387-99. 미소장
33 Effects of Fermented Red Ginseng Extracts on Hyperglycemia in Streptozotocin-induced Diabetic Rats 소장
34 Antioxidant Effects of Fermented Red Ginseng Extracts in Streptozotocin-Induced Diabetic Rats 소장
35 Ra KS, Choi JW. Enhancement of cyclo-His-Pro (CHP) content from soybean fermented with Bacillus amyloliquefaciens CHP-12 and its anti-diabetic effect. KSBB J. 2011 ; 26 : 41-8. 미소장
36 Fermented soybeans by Rhizopus oligosporus reduce femoral bone loss in ovariectomized rats 소장
37 Contents of Naringin, Hesperidin and Neohesperidin in Premature Korean Citrus Fruits 소장
38 Song MH, Bae JT, Ko HJ, Jang YM, Lee JD, Lee GS, Pyo HB. Anti-oxidant effect and anti-inflammatory of fermented Citrus Unshiu peel extract by using Schizophyllum commune. J Soc Cosmet Sci Korea. 2011 ; 37(4) : 351-6. 미소장

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