Title Page
Contents
List of Abbreviations 7
Abstract 8
CHAPTER I. General background 12
CHAPTER II. The pharmacological inhibition of ERK5 enhances apoptosis in acute myeloid leukemia cells 19
Introduction 20
Materials and Methods 22
Results 25
Discussion 39
CHAPTER III. BET inhibitor JQ1 enhances the responses to all-trans retinoic acid in HL-60 and MV4-11 leukemia cells 42
Introduction 43
Materials and Methods 45
Results 48
Discussion 61
References 64
Abstract(in Korean) 83
Chapter II. 26
Figure 1. Granulocyte colony-stimulating factor (G-CSF) induces... 26
Figure 2. G-CSF-mediated ERK5 activation induces the... 30
Figure 3. The inhibition of ERK5 by XMD8-92 induces apoptosis... 34
Figure 4. The inhibition of ERK5 by XMD-8-92 regulates on cell... 38
Chapter III. 50
Figure 1. JQ1 synergizes with ATRA to reduce proliferation of... 50
Figure 2. Effect of JQ1 on ATRA-induced HL-60 cell... 53
Figure 3. Effect of combined treatment with JQ1 and ATRA on... 55
Figure 4. Effect of JQ1 and ATRA on the expression of c-Myc... 59
Figure 5. The proposed role of BET inhibitor in ATRA-induced... 60