Title Page
Contents
Ⅰ. Introduction 8
Ⅱ. Literature review 11
1. Autosomal dominant polycystic kidney disease (ADPKD) 11
2. Dietary patterns for complications of kidney disease 13
3. Risk of sarcopenia in patient with kidney disease 16
4. Dietary recommendation for sarcopenia 18
Ⅲ. Methods 20
1. Study subjects 20
2. Measurement 21
3. Diagnostic criteria of sarcopenia 24
4. Dietary pattern index 25
5. Statistical analysis 28
Ⅳ. Results 29
1. General characteristics of subjects according to the presence of sarcopenia 29
2. Anthropometric indices of subjects according to the presence of sarcopenia 32
3. Blood pressure and organ volumes of the subjects according to the presence of sarcopenia 34
4. Biochemical parameters of the subjects according to the presence of sarcopenia 36
5. Dietary intake of the subjects according to the presence of sarcopenia 41
6. Energy-adjusted dietary intake of the subjects according to the presence of sarcopenia 41
7. Dietary pattern indices of the subjects according to the presence of sarcopenia 49
8. Score of each food group that constitutes DASH score of the subjects according to the presence of sarcopenia 51
9. Intake of each food group that constitutes DASH score of the subjects according to the presence of sarcopenia 51
10. Specific foods intake in the food groups that constitute DASH score of the subjects according to the presence of sarcopenia 54
11. Correlation coefficients between dietary pattern indices and HGS (max) 62
12. Correlation coefficients between dietary pattern indices and HGS (average) 62
13. Odds ratios for sarcopenia by dietary pattern indices 64
14. Factor analysis for score of food groups constituting DASH score in the subjects 66
15. Regression analysis for DASH score and sarcopenia by DASH score food group factors in the subjects 69
Ⅴ. Discussion 72
References 76
국문초록 96
Table 1. Diagnostic criteria for sarcopenia of different international consensus 17
Table 2. Scoring criteria for DASH and aMED 26
Table 3. General characteristics of the subjects 30
Table 4. Anthropometric indices of the subjects 33
Table 5. Blood pressure and organ volumes of the subjects 35
Table 6. Biochemical parameters of the subjects 37
Table 7. Dietary intake of the subjects 42
Table 8. Energy-adjusted dietary intake (per 1,000 kcal) of the subjects 46
Table 9. Dietary pattern indices of the subjects 50
Table 10. Comparison of DASH score components score in subjects 52
Table 11. Comparison of DASH score components intake in subjects 53
Table 12. Comparison of DASH score component of specific foods in subjects 56
Table 13. Pearson correlation coefficients between dietary pattern indices and HGS (max) 63
Table 14. Pearson correlation coefficients between dietary pattern indices and HGS (average) 63
Table 15. Factor analysis for score of food groups constituting DASH score in the subjects 67
Table 16. Comparison of presence or absence of sarcopenia and tertiles of HGS according to DASH score factors 68
Table 17. Multiple logistic regression analysis for DASH score by DASH score food group factors in total subjects 70
Table 18. Multiple logistic regression analysis for DASH score by DASH score food group factors in non-sarcopenia group 70
Table 19. Multiple logistic regression analysis for DASH score by DASH score food group factors in sarcopenia group 70
Table 20. Multiple logistic regression analysis for HGS by DASH score food group factors in total subjects 71
Table 21. Logistic regression analysis for sarcopenia by DASH score food group factors in total subjects 71
Table 22. Multinomial logistic regression analysis for tertiles of HGS by DASH score food group factors in total subjects 71
Figure 1. Flow diagram of patients who were enrolled, and participated in this study 20
Figure 2. Forest plot of odds ratios for the risk of sarcopenia by dietary pattern indices 65