Title Page
Contents
국문초록 8
ABSTRACT 10
I. Introduction 12
II. Objectives 15
III. Materials and Methods 16
1. Materials 16
1.1. Ethical approval 16
1.2. Study data and population 16
1.3. Sampling strategy of PZA 17
1.4. Plasma Quantification of PZA 17
2. Methods 19
2.1. Population Pharmacokinetic Modeling and Simulation 19
IV. Results 23
V. Discussion 36
VI. Conclusion 41
References 42
Table 1. Patient demographic characteristics 24
Table 2. PZA population PK parameter estimates for the final model and bootstrap results. 27
Table 3. Prediction Errors Calculated by Population Prediction and Individual Prediction With External Validation. 32
Figure 1. Goodness-of-fit plots of the final model. 29
Figure 2. Prediction-corrected visual predictive checks. 30
Figure 3. External validation and model comparison. 31
Figure 4. Relationship between age and DM with PK parameters. 34