Title Page
Contents
ABSTRACT 8
I. Introduction 10
II. Objectives 11
III. Materials and Methods 12
IV. Results 17
V. Discussion 20
VI. Conclusion 23
References 24
Figure legends 44
Table 1. Baseline characteristics of the patients 30
Table 2. Risk of mortality according to the acidosis trajectories 32
Table 3. Comparison of mortality after matching propensity scores 33
Figure 1. Flow diagram for study subjects. ABGA, artery blood gas analysis. 34
Figure 2. Clustering of pH trajectories during the first 24 hours after starting continuous renal replacement therapy. 35
Figure 3. Kaplan–Meier curves of pH clusters for all-cause mortality. 36
Figure 4. Clustering of trajectories in high sensitivity C-reactive protein between 24 and 72 hours after starting continuous renal replacement therapy. 37
Figure 5. Kaplan–Meier survival curves of high-sensitivity C-reactive protein clusters for all-cause mortality. 38
Figure 6. Distribution of high-sensitivity C-reactive protein (CRP) clusters according to pH clusters. 39
Figure S1. Histogram of arterial partial pressure level of carbon dioxide according to pH clusters. 40
Figure S2. Histogram of arterial bicarbonate level according to pH clusters. 41
Figure S3. Histogram of serum anion gap according to pH clusters. 42
Figure S4. Histogram of serum lactate level according to pH clusters. 43