표제지
국문초록
목차
I. 서론 10
1. 연구의 필요성 및 목적 10
2. 연구가설 14
II. 연구방법 15
1. 실험동물 및 사육 15
2. 알츠하이머 질환 유도 및 실데나필 투여 15
3. 운동 방법 16
4. 행동검사 16
1) 수동회피검사(Passive avoidance test) 16
2) Nest building test 17
2) 수중미로검사(Water maze test) 18
5. 뇌 적출 18
6. Western blot analysis 19
7. 자료처리방법 19
III. 연구결과 20
1. 행동검사 20
1) 집단 간 수동회피검사(Passive avoidance test) 차이 20
2) 집단 간 Nest building test 차이 21
3) 집단 간 Water maze test 차이 22
2. 알츠하이머 질환의 병리적 특징 23
1) 집단 간 Aβ, PHF-1, TNF α 발현 수준 차이 23
3. 뇌혈관 기능 관련 지표의 변화 24
1) 집단 간 Occludin, Claudin-5, ZO-1 발현 수준 차이 24
4. 항산화 기능의 변화 25
1) 집단 간 SOD-1, SOD-2, CS 발현 수준 차이 25
IV. 논의 26
V. 결론 30
참고문헌 31
ABSTRACT 39
Table 1. Treadmill Exercise Protocol 16
Table 2. Nest building test Rating Scale 17
Figure 1. Latencies to enter dark chamber on retention testing session after 48 hours of acquisition phase in passive avoidance test. CON :... 20
Figure 2. Difference of Nest building test in each group. (A) Nests representative image in each group. (B) Nest formation score in each... 21
Figure 3. Difference of Water maze test in each group. (A) Latency to 1st entrance to target in each group. (B) Distance to target in each group. (C)...[이미지참조] 22
Figure 4. Difference of Aβ, PHF-1, TNFα activation level in each group. (A) Representative image of Aβ, PHF-1, TNFα expression level in... 23
Figure 5. Difference of Occludin, Claudin-5, ZO-1 activation level in each group. (A) Representative image of Occludin, Claudin-5, ZO-1 expression... 24
Figure 6. Difference of SOD-1, SOD-2, CS activation level in each group. (A) Representative image of SOD-1, SOD-2, CS expression level in... 25