Title Page
Contents
국문 요약 7
Abstract 9
Ⅰ. Introduction 11
Ⅱ. Materials and methods 19
A. Materials 19
B. Preparation of IR780/PTX@ MB 20
C. Characterization of IR780/PTX@MB 21
D. NIR-induced drug release profile and temperature change 22
Ⅲ. Results and discussion 23
Ⅳ. Conclusion 31
Reference 32
Figure 1. Schematic illustration of several substances attached to lipid microbubble. 13
Figure 2. Schematic illustration of near-infrared induced on-demand drug release from microbubble. 17
Figure 3. Schematic illustration of preparation of drug-loaded microbubble. (a) Mixture of materials and surfactant (b) Syringe... 23
Figure 4. Optical microscopy images of microbubbles (a-d) without NIR (e-h) NIR 1.0 (i) schematic illustration. 24
Figure 5. Size distribution of microbubbles. 25
Figure 6. Temperature changes upon NIR irradiation with different laser powers. 27
Figure 7. (a) Drug release upon NIR irradiation with different laser powers. (b) Cumulative drug release upon NIR irradiation with 1.0 W/cm². 29