Title Page
Contents
ABSTRACT 9
Ⅰ. Introduction 10
Ⅱ. Materials and Methods 15
2.1. Seasonal variation and amniotic fluid volume 15
2.1.1. Patients enrollment of seasonal variation and amniotic fluid volume 15
2.1.2. Measuring the amniotic fluid index according to the seasons 18
2.1.3. Statistical analysis and Institutional review board approval 19
2.2. Seasonal variation and spontaneous preterm birth 20
2.2.1. Patient enrollment of seasonal variation and spontaneous preterm birth 20
2.2.2. Definition of the four seasons and spontaneous preterm birth 22
2.2.3. Statistical analysis and institutional review board approval 23
Ⅲ. Result 24
3.1. Seasonal variation and amniotic fluid volume 24
3.1.1. Average amniotic fluid index throughout each gestational age 24
3.1.2. Maternal characteristics of the study participants 25
3.1.3. Amniotic fluid index differences between summer and non-summer seasons 26
3.1.4. Borderline oligohydramnios risk 28
3.1.5. Neonatal outcomes 29
3.2. Seasonal variation and Spontaneous preterm birth 31
3.2.1. Maternal characteristics of Spontaneous preterm birth at the time of admission 31
3.2.2. Spontaneous preterm birth rate based on seasons at delivery 33
3.2.3. SPB rates based on the seasons at delivery according to the etiologies 34
Ⅳ. Discussion 35
4.1. Seasonal variation and amniotic fluid volume 35
4.2. Seasonal variation and spontaneous preterm birth 37
Ⅴ. Conclusion 42
References 43
Abstract (in Korean) 48
〈Table 1〉 Clinical characteristics of the study population 25
〈Table 2〉 Amniotic fluid index, temperature, and humidity in the summer versus non-summer seasons for 15 years 26
〈Table 3〉 Correlation among amniotic fluid index, temperature, and humidity in the late 2nd and 3rd trimester of pregnancy.[이미지참조] 27
〈Table 4〉 Risk of borderline oligohydramnios in summer versus non-summer seasons on 2nd and 3rd trimester of pregnancy.[이미지참조] 28
〈Table 5〉 Comparison of neonatal outcomes between the normal AFI and borderline oligohydramnios groups in the 3rd trimester[이미지참조] 30
〈Table 6〉 Maternal characteristics at the time of admission for preterm birth 32
〈Figure 1〉 Patient enrollment for seasonal variation and amniotic fluid volume 16
〈Figure 2〉 Patient enrollment data for seasonal variation and spontaneous preterm birth 21
〈Figure 3〉 Average amniotic fluid index for each gestational age 24
〈Figure 4〉 SPB rate based on the seasons at delivery 33
〈Figure 5〉 The SPB rate based on the seasons at delivery according to etiology 34