Title Page
Contents
ABSTRACT 7
Ⅰ. Introduction 9
Ⅱ. Materials & Methods 12
2.1. Animals 12
2.2. Materials 12
2.3. Preparation of acute hippocampal slices 13
2.4. Synaptosomal fractionation 13
2.5. Western blot 14
2.6. Electrophysiology 14
2.7. Statistics 15
Ⅲ. Results 16
3.1. Confirming the LTP enhancement effects of PT extract 16
3.2. Confirming the LTP enhancement effects of PT components 19
3.3. Confirming the LTP enhancement effects of TMCA 23
3.4. Effects of TMCA on CP-AMPARs 26
3.5. LTP Enhancement effects of TMCA and CP-AMPARs 29
3.6. LTP Enhancement effects of TMCA and PKA 31
Ⅳ. Discussion 33
References 37
Abstract (in Korean) 44
Figure. 1. LTP-enhancing effect of PT extract 17
Figure. 2. Structures of PT components 21
Figure. 3. The effect of PT components on LTP 22
Figure. 4. LTP-enhancing effect of TMCA 24
Figure. 5. Effects of TMCA on GluA1 phosphorylation 27
Figure. 6. Role of CP-AMPARs in LTP enhancement by TMCA 30
Figure. 7. Role of PKA in LTP enhancement by TMCA 32