표제지
목차
국문 초록 10
ABSTRACT 13
제1장 서론 17
제2장 이론적 배경 20
1. 결명자의 효능 20
2. 방사선의 인체 내 생물학적 작용 22
A. 전리방사선 22
B. 흡수선량, 등가선량, 유효선량 23
C. 방사선의 간접작용 26
D. 방사선 피폭에 의한 인체 내 방사선 장해 27
E. 인체 내 방사선 방호물질의 작용 28
F. 자유라디칼과 항산화 작용 30
3. 천연 방사선 방호제의 선행연구 31
4. 연구의 목적 32
제3장 실험재료 및 실험방법 33
1. 실험재료 33
A. 결명자 에탄올 추출물의 제조 33
B. 실험동물 사육 34
C. 실험군 편성 34
2. 실험방법 36
A. 방사선 조사 37
B. 시료채취 40
C. 혈액 시료 채취 및 혈액학적 변화 분석 40
D. SOD 활성도 평가 40
E. 조직 채취 및 조직학적 분석 42
F. 통계처리 42
제4장 결과 43
1. 혈구 성분의 변화 43
A. 적혈구 43
B. 혈소판 45
C. 백혈구 47
D. 림프구 49
2. SOD 활성 분석 51
3. 조직학적 변화 관찰 53
A. 비장 53
4. 조직학적 변화 55
B. 간 55
C. 소장 62
제5장 고찰 70
제6장 결론 76
참고문헌 78
Table 1. Radiation weighting factors in from ICRP Publication 103 24
Table 2. Tissue weighting factors in from ICRP Publication 103 25
Table 3. Experimental animal group 35
Table 4. Result of Red blood cell in rats at 1 and 7 days 44
Table 5. Result of Platelt in rats at 1 and 7 days 46
Table 6. Result of White blood cell in rats at 1 and 7 days 48
Table 7. Result of Lymphocyte in rats at 1 and 7 days 50
Table 8. Result of SOD activity of blood in rats at 7 days 52
Table 9. Result of spleen index in SD rats at 1, 7 days 54
Table 10. Result of Villi Length in SD Rat at 1 Day, 7 days 69
Figure 1. Survey on the number of radiation workers 19
Figure 2. Scheme of the experimental method. 36
Figure 3. Observation of liver cells in male rats on H&E stained by opt ical microscopy at 1 day (2 Gy) 56
Figure 4. Observation of liver cells in male rats on H&E stained by opt ical microscopy at 1 day (7 Gy) 57
Figure 5. Observation of liver cells in male rats on H&E stained by opt ical microscopy at 1 day (12 Gy) 58
Figure 6. Observation of liver cells in male rats on H&E stained by opt ical microscopy at 7 days (2 Gy) 59
Figure 7. Observation of liver cells in male rats on H&E stained by opt ical microscopy at 7 days (7 Gy) 60
Figure 8. Observation of liver cells in male rats on H&E stained by opt ical microscopy at 7 days (12 Gy) 61
Figure 9. Observation of after radiation 1 day rat's intestine cells and v illi length on H&E stained by optical microscopy (2 Gy) 63
Figure 10. Observation of after radiation 1 day rat's intestine cells and villi length on H&E stained by optical microscopy (7 Gy) 64
Figure 11. Observation of after radiation 1 day rat's intestine cells and villi length on H&E stained by optical microscopy (12 Gy) 65
Figure 12. Observation of after radiation 7 days rat's intestine cells and villi length on H&E stained by optical microscopy (2 Gy) 66
Figure 13. Observation of after radiation 7 days rat's intestine cells and villi length on H&E stained by optical microscopy (7 Gy) 67
Figure 14. Observation of after radiation 7 days rat's intestine cells and villi length on H&E stained by optical microscopy (12 Gy) 68