Title Page
Contents
ABSTRACT 8
Ⅰ. Introduction 10
Ⅱ. Materials and Methods 13
2.1. Patients and study design 13
2.2. Definition of the conventional scoring systems 14
2.2.1. Systemic inflammatory response syndrome 14
2.2.2. Quick sequential organ failure assessment 14
2.2.3. Acute patient physiology and laboratory evaluation 15
2.3. Criteria of the modified qSOFA scoring systems 17
2.3.1. qSIRS model 17
2.3.2. qSOFA-lactate model 17
2.3.3. qSOFA-CRP model 18
2.4. Statistical analysis 20
Ⅲ. Results 21
3.1. Case identification 21
3.2. Determination of cutoff value for qSOFA-CRP model 24
3.3. Comparison between survivors and non-survivors for each scoring system 26
3.4. Comparative evaluation of mortality prediction by each scoring system 28
Ⅳ. Discussion 32
Ⅴ. Conclusion 37
References 38
Abstract (in Korean) 43
Table 1. SIRS, qSOFA, and APPLEfast criteria definition 16
Table 2. qSIRS, qSOFA-lactate criteria definition 19
Table 3. Patients' characteristics and comparison of physical and laboratory findings between survivors and non-survivors, with mean ± SD or median (range) calculations 23
Table 4. Statistical significance comparison of scoring systems between survivor and non-survivor groups 27
Table 5. Contingency tables showing the sensitivity, specificity, positive and negative predictive values and odds ratios for mortality prediction 31
Figure 1. Receiver operating characteristic curve of C-reactive protein. 25
Figure 2. Receiver operating characteristic (ROC) curve of SIRS, qSOFA, APPLEfast, qSIRS, qSOFA-lactate, qSOFA-CRP model. 29