Purpose: This study was conducted to identify the clinical characteristics and risk factors on the occurrence of variant
angina, and to examine the predicting factors on the vascular endothelial dysfunction of the patients with variant angina.
Methods: A total of 134 patients diagnosed with variant angina were recruited from 2006 to 2008. The degrees of
endothelial dysfunction were measured and recorded by the researcher using the values of flow-mediated vasodilation
of their brachial arteries and Nitroglycerine-mediated dilation. Subjects' demographic data and risk factors were
gathered after obtaining informed consent, and their electronic medical records were reviewed to collect laboratory
data. Results: The mean age was 54.2 ?9.6 years and 52% was male patients. More than 50% of the male patients
were cigarette smokers and had hypercholesterolemia. 84% of the male patients and 70% of the female patients had
more than one risk factor of cardiovascular disease. A stepwise multiple regression analysis showed that smoking and
Tailored educational interventions for smoking cessation and cholesterol management are needed to prevent
recurrence of angina attack for patients with variant angina and to prevent cardiovascular disease for middle-aged
workers.