Objectives : This study was designed to investigate the effects of acupuncture on Taegye(KI₃) Taebaek(SP₃) draining and determine the mechanism of action of PCBL by measuring the changes of regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in normal rats.
Methods : This study was designed to investigate whether acupuncture on Taegye(KI₃)·Taebaek(SP₃) draining affect Regional cerebral blood flow(rCBF), Mean arterial blood pressure(MABP) in normal rats. To make manifest whether acupuncture on Taegye(KI₃)·Taebaek(SP₃) draining was mediated by inhibitor of cyclooxygenase or guanylate cyclase which diate arterial diameter.
Results
1. Acupuncture on Taegye(KI₃)·Taebaek(SP₃) draining significantly increased rCBF but decreased MABP. This result suggests that Acupuncturing on Taegye(KI₃)·Taebaek(SP₃) draining might significantly increase rCBF by dilating arterial diameter.
2. Acupuncture on Taegye(KI₃)·Taebaek(SP₃) draining induced increase of rCBF was significantly inhibited by pretreatment with indomethacin (1 mg/kg, i.p.), an inhibitor of cyclooxygenase.
3. This result suggests that the action of Acupuncture on Taegye(KI₃)·Taebaek(SP₃) draining might be mediated by cyclooxygenase.