Objectives : This study was designed to evaluate the effects of Desmodii herb pharmacopuncture (DH-HA) at KI_10_(Umgok) on nephritis induced by lipopolysaccharide(LPS) in rat.
Methods : Rats were injected LPS to induce nephritis. DH-HA group was treated with DH-HA at KI_10_ three times for a week, NP group with 26 gauge needle, saline group with normal saline. To evaluate the effects of DH-HA at KI_10_ on nephritis in rats, RBC, WBC, neutrophil in blood, TNF-a, CINC-1 in serum, creatinine and total protein in urine, renal TNF-a, renal MPO were measured and renal tissue was analyzed.
Results : WBC in blood, CINC-1 in serum, renal MPO significantly reduced in DH-HA group.
Conclusions : DH-HA at KI_10_ is effective for nephritis in LPS-induced rats. Therefore, DH-HA at KI_10_ may be useful for nephritis in clinical field.