Objectives : This study aimed to evaluate the effects of Malvae Semen herbal-acupuncture (MS-HA) atKI_10_(Eumgok) on nephritis induced by lipopolysaccharide (LPS) in rat.
Methods : Rats with nephritis induced by LPS, were treated with Malvae Semen herbal-acupuncture(MS-HA) injection at KI_10_. Two control groups, N.P group and Saline group, were treated with 26 gauge needle at KI_10_, 3 times a week. In Saline group, normal saline was injected at KI_10_.
To evaluate the effects of Malvae Semen Herbal-acupuncture at KI_10_ on nephritis in rats, WBC, Neutrophils in blood, BUN, Creatinine, TNF-a, CINC-1 in serum, urinal volume, creatinine, total protein in urine and renal TNF-a, renal tissue were analyzed.
Results : MS-HA at KI_10_ significantly reduced WBC and neutrophil in blood, TNF-α in serum of LPS-stimulated rats. MS-HA at KI_10_ significantly reduced total protein level in urine. MS-HA at KI_10_ reduced accumulation of neutrophil in renal tissue of LPS-stimulated rats.
Conclusions : Taken together, MS-HA at KI_10_ has a therapeutic effect on nephritis in LPS-stimulated rat.
Therefore, it is suggested that MS-HA at KI_10_ may be an useful therapeutics for nephritis in clinical field.