2666 is the ambitious literary testament of Roberto Bolano which focuses on Santa Teresa, the fictionalized Ciudad Juarez. The mysterious killings, based on a real-life serial crimes that broke out in Ciudad Juarez in the nineties, become the center of 2666. This supernovel consists of five parts, each with autonomous life and form. This article studies not only the form and the meaning of “The Part of the Crimes”, the fourth part which is the figuratively and literally heart of the novel, but also its relation with another four Parts of the novel. “The Part of the Crimes” details in forensic style the deaths or the discovery of the corpses of the 108 women murdered in Santa Teresa and the surrounding area in the period between January 1993 and December 1997. Most of them were raped and tortured and then tossed aside like so much garbage. In this novel, a woman reporter comments on this femicide: No one pays attention to these killings, but the secret of the world is hidden in them. To reveal this secret, this article attempts to explain the use of the documentary style and the meaning of terrific fugue-like sequences and damning repetitions. The semantic relation of this part with the epigraph and mysterious title will be carried out as a final step for the revelation of the apocalyptical sense of this novel.