Deciding on the appropriate antiplatelet therapy is a challenge when treating patients with idiopathic thrombocytopenicpurpura (ITP) and who are undergoing percutaneous coronary intervention (PCI). We describe here acase of PCI in a patient with chronic, refractory ITP. A 61-year-old woman presented with exertional chest painand a low platelet count (4×109/L) at admission. Coronary angiography revealed 99% stenosis of the mid leftanterior descending artery and 95% stenosis of the mid left circumflex artery. Antiplatelet agents couldn’t beadministered because of the risk of bleeding. After transfusion of platelets and administering intravenous immunoglobulin,we deployed baremetal stents in both lesions without administering any antiplatelet agents. Althoughfocal in-stent restenosis developed 5 months later, there was no episode of stent thrombosis despite not usingantiplatelet agents. The present case suggests that the rate of stent thrombosis may be lower was previously thoughtand antiplatelet therapy may be considered on a case by case for patient suffering with thrombocytopenia.