Pig chronic wasting disease, including porcine reproductive and respiratory syndrome (PRRS) and postweaning multisystemic wastingsyndrome (PMWS), have made a continuous economic damage in pig farms. Airborne spread of livestock viruses are an importantspread factor which is difficult to analyze due to invisible airflow and limitation of measurement. The objective of this study is toanalyze airborne disease spread between buildings in the experimental pig farm by means of field experiment and computational fluiddynamics (CFD). The field experiments were conducted to capture airborne virus using air sampler and teflon filter along multi pointsin the experimental pig farm. The samples were tested in terms of virus detection resulting in positive reaction for PRRS and PCV-2viruses, which can be a firm evidence of airborne virus spread. The CFD simulation model was developed by considering complextopography, wind conditions, building arrangement, and ventilation systems and was used to analyze airborne virus spread accordingto different wind conditions. The CFD computed result showed a possibility of airborne virus spread via livestock aerosol from infectedpig house to neighboring pig houses according to wind directions. The CFD simulation technique is expected to provide significantdata for estimating and making a counterplan against airborne disease spread.