Purpose: To investigate whether volumetric analysis based on T2WI and contrastenhanced(CE) T1WI can distinguish between isocitrate dehydrogenase-1 mutationpositive(IDH1P) and -negative (IDH1N) glioblastomas (GBMs).
Materials and Methods: We retrospectively enrolled 109 patients with histopathologicallyproven GBMs after surgery or stereotactic biopsy and preoperative MR imaging.
We measured the whole-tumor volume in each patient using a semiautomaticsegmentation method based on both T2WI and CE T1WI. We compared the tumorvolumes between IDH1P (n = 12) and IDH1N (n = 97) GBMs using an unpaired t-test.
In addition, we performed receiver operating characteristic (ROC) analysis for thedifferentiation of IDH1P and IDH1N GBMs using the tumor volumes based on T2WIand CE T1WI.
Conclusion: Volumetric analysis of T2WI and CE T1WI could enable IDH1P GBMs tobe distinguished from IDH1N GBMs. We assumed that secondary GBMs with IDH1Punderwent stepwise progression and were more infiltrative than those with IDH1N,which might have resulted in the differences in tumor volume.