This study conducted Japan in person to study wellness tourism in Japan. A survey was conducted targeting Japanese wellness tourists, and a survey through expert interviews was conducted in parallel. The survey period was conducted from January to April 2023. To verify the research hypothesis, model analysis using structural equations was conducted. SPSS 24.0 and AMOS 24.0 were used as statistical package programs for data analysis. First, the causal relationship between wellness tourism and quality of life is verified by only significant causal relationships between social wellness, which is a sub-factor of wellness tourism, self-esteem and self-achievement, which are sub-factors of quality of life, and physical wellness and self-esteem. A positive (+) relationship was established, and it was confirmed that a significant positive (+) causal relationship was not established for the sub-factors. Second, the results and implications of verifying differences in wellness tourism according to demographic characteristics are as follows. As a result of verifying the differences in wellness tourism according to gender, it was found that there were no significant differences in all sub-factors of wellness tourism according to gender. As a result of verifying the differences in wellness tourism according to age, it was found that there were significant differences in all sub-factors of wellness tourism according to age. As a result of verifying the difference in wellness tourism according to marital status, it was found that there was no significant difference in all sub-factors of wellness tourism depending on marital status. As a result of verifying the difference in wellness tourism according to educational background, it was found that there was a significant difference in emotional wellness and intellectual wellness, which are sub-factors of wellness tourism according to educational background, but there was no significant difference in social wellness and physical wellness.