Ontological addiction theory (OAT) is a metaphysical model of human suffering which asserts that human beings are 1. inclined to construct and become addicted to flawed beliefs concerning the manner in which they exist, and that 2. these beliefs can become maladaptive, leading to range of functional impairments. The theoretical underpinnings of OAT derive from Buddhist theory, metaphysics and to a lesser extent clinical psychology, with a central view being that all phenomena, including the self, do not manifest independently or inherently. By synthesizing the theoretical and empirical contributions to OAT from the past decade, the present paper provides an updated perspective on how the theory continues to evolve. A further aim of the paper is to further outline and evaluate the path to treating ontological addiction, which involves phases of 1. becoming aware of the self, 2. deconstructing the self, and 3. reconstructing a dynamic and non-dual self. It is concluded that these treatment phases highlight the underlying assumption in OAT that although suffering is a fundamental aspect of the human condition, life itself can be lived as a practice of meditation, with each moment reflecting an opportunity for growth, insight and spiritual transcendence.