Wearable sensors designed for strain, pressure, and temperature measurements are essential for monitoring human movements, healthstatus, physiological data, and responses to external stimuli. Notably, recent research has led to the development of high-performancewearable sensors using innovative materials and device structures that exhibit ultra-high sensitivity compared with their commercialcounterparts. However, the quest for accurate sensing has identified a critical challenge. Specifically, the mechanical flexibility of thesubstrates in wearable sensors can introduce interference signals, particularly when subjected to varying external stimuli and environmentalconditions, potentially resulting in signal crosstalk and compromised data fidelity. Consequently, the pursuit of non-interferencesensing technology is pivotal for enabling independent measurements of concurrent input signals related to strain, pressure, andtemperature, ensuring precise signal acquisition. In this comprehensive review, we present an overview of the recent advances in noninterferencesensing strategies. We explore various fabrication methods for sensing strain, pressure, and temperature, emphasizing theuse of hybrid composite materials with distinct mechanical properties. This review contributes to the understanding of critical developmentsin wearable sensor technology that are vital for their ongoing application and evolution in numerous fields.