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용역연구사업 연구결과보고서[개인신상정보 삭제]
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목차
연구결과보고서 요약문[개인신상정보 삭제] 5
Summary[개인신상정보 삭제] 7
총괄연구개발과제 연구결과 9
제1장 총괄연구개발과제의 최종 연구개발 목표 9
제2장 총괄연구개발과제의 최종 연구개발 내용 및 방법 12
제3장 총괄연구개발과제의 최종 연구개발 결과 28
제4장 총괄연구개발과제의 최종 연구결과 고찰 및 결론 32
제5장 총괄연구개발과제의 연구성과 35
제6장 기타 중요변경사항 37
제7장 참고문헌 38
제8장 첨부서류 41
총괄 연구과제 요약[개인신상정보 삭제] 223
8.1. F344 랫드에 대한 목단피의 2주 반복경구투여 독성시험(DRF) 41
Table 1. Mortality of F344 rats 43
Table 2. Clinical signs of F344 rats 43
Table 3. Body weights of male F344 rats 44
Table 4. Body weights of female F344 rats 45
Table 5. Urinalysis values of male F344 rats 46
Table 6. Urinalysis values of female F344 rats 47
Table 7. Hematological values of male F344 rats 48
Table 8. Hematological values of female F344 rats 49
Table 9. Blood Chemical values of male F344 rats 50
Table 10. Blood Chemical values of female F344 rats 51
Table 11. Absolute organ weights of F344 rats 52
Table 12. Relative organ weights of F344 rats 53
8.2. 목단피의 13주 반복경구투여 독성시험 102
Table 1. Mortality of F344 rats 104
Table 2. Clinical signs of F344 rats 104
Table 3-1. Body weights of 13 weeks oral toxicity study in male F344 rats 105
Table 3-2. Body weights of 13 weeks oral toxicity study in female F344 rats 105
Table 4-1. Feed consumptions of 13 weeks oral toxicity study in male F344 rats 106
Table 4-2. Feed consumptions of 13 weeks oral toxicity study in female F344 rats 106
Table 5-1. Water consumptions of 13 weeks oral toxicity study in male F344 rats 107
Table 5-2. Water consumptions of 13 weeks oral toxicity study in female F344 rats 107
Table 6-1. Urinalysis results of 13 weeks oral toxicity study in male F344 rats 108
Table 6-2. Urinalysis results of 13 weeks oral toxicity study in female F344 rats 108
Table 7-1. Hematological values of 13 weeks oral toxicity study in male F344 rats 109
Table 7-2. Hematological values of 13 weeks oral toxicity study in female F344 rats 110
Table 8-1. Blood chemistry values of 13 weeks oral toxicity study in male F344 rats 111
Table 8-2. Blood chemistry values of 13 weeks oral toxicity study in female F344 rats 112
Table 9. Necropsy findings of 13 weeks oral toxicity study in F344 rats 113
Table 10-1. Organ weights of 13 weeks oral toxicity study in F344 rats 116
Table 10-2. Organ weight to body weights ratio of 13 weeks oral toxicity study in F344 rats 117
Table 11-1. Histopathological findings of 13 weeks oral toxicity study in male F344 rats 118
Table 11-2. Histopathological findings of 13 weeks oral toxicity study in female F344 rats 121
Table 12. Sperm morphology of 13 weeks oral toxicity study in male F344 rats 124
Table 13. Vaginal cytology of 13 weeks oral toxicity study in female F344 rats 124
Appendix 1. Clinical signs of male F344 rats 54
Appendix 2. Clinical signs of female F344 rats 57
Appendix 3. Body weights of male F344 rats 60
Appendix 4. Body weights of female F344 rats 63
Appendix 5. Urinalytical values of male F344 rats 66
Appendix 6. Urinalytical values of female F344 rats 72
Appendix 7. Hematological values of male F344 rats 78
Appendix 8. Hematological values of female F344 rats 84
Appendix 9. Blood Chemical values of male F344 rats 90
Appendix 10. Blood Chemical values of female F344 rats 96
Appendix 1. Clinical signs of male F344 rats 125
Appendix 2-1. Body weights of 13 weeks oral toxicity study in male F344 rats 173
Appendix 2-2. Body weights of 13 weeks oral toxicity study in female F344 rats 175
Appendix 3-1. Urinalysis results of 13 weeks oral toxicity study in male F344 rats 177
Appendix 3-2. Urinalysis results of 13 weeks oral toxicity study in female F344 rats 178
Appendix 4-1. Hematological values of 13 weeks oral toxicity study in male F344 rats 179
Appendix 4-2. Hematological values of 13 weeks oral toxicity study in female F344 rats 182
Appendix 5-1. Blood chemistry values of 13 weeks oral toxicity study in male F344 rats 185
Appendix 5-2. Blood chemistry values of 13 weeks oral toxicity study in female F344 rats 188
Appendix 6-1. Necropsy findings of 13 weeks oral toxicity study in male F344 rats 191
Appendix 6-2. Necropsy findings of 13 weeks oral toxicity study in female F344 rats 192
Appendix 7-1. Organ weights of 13 weeks oral toxicity study in male F344 rats 193
Appendix 7-2. Organ weights of 13 weeks oral toxicity study in female F344 rats 195
Appendix 8-1. Organ weight to body weight ratio of 13 weeks oral toxicity study in male F344 rats 197
Appendix 8-2. Organ weight to body weight ratio of 13 weeks oral toxicity study in female F344 rats 199
Appendix 9-1. Histopathological findings of 13 weeks oral toxicity study in male F344 rats 201
Appendix 9-2. Histopathological findings of 13 weeks oral toxicity study in female F344 rats 203
Appendix 10. Sperm morphology of 13 weeks oral toxicity study in male F344 rats 205
Appendix 11. Vaginal cytology of 13 weeks oral toxicity study in female F344 rats 207
Fig. 1. Body weights of 2 weeks oral tokicity study in F344 rats 42
Fig. 1. Body weights of 13 weeks oral toxicity study in male F344 rats 103
Fig. 2. Body weights of 13 weeks oral toxicity study in female F344 rats 103