표제지
목차
보고서 초록 3
요약문 4
SUMMARY 6
제1장 명상기반 정량화 뇌파와 24시간 심전도를 이용한 심-뇌 상관성 분석을 위한 임상연구 모델구축 10
Ⅰ. 연구 대상인 '심(心)'에 대한 명확한 인식론 확립 10
Ⅱ. 예비적 임상연구: 정량화 뇌파와 24시간 활동심전도의 상관성 연구를 위한 명상기반 예비적 임상연구 18
가. 연구목적 18
나. 연구방법 18
다. 연구결과 25
Ⅲ. 본 임상연구 수행: 정량화 뇌파와 24시간 활동심전도의 상관성 연구를 위한 명상기반 임상연구 35
가. 연구목적 35
나. 연구대상 및 방법 35
1. 硏究對象 35
2. 硏究方法 36
3. 명상 시행 방법 및 내용 45
4. 統計處理 49
다. 연구결과 50
1. 연구대상자들의 사회 인구학적 특징과 차이 검증 50
2. FFMQ-S, K-PANAS, CSEI-S 설문지 검사 53
3. 24시간 활동 심전도(24-hours holter monitoring)를 통한 HRV 측정 56
4. 정량화 뇌파(QEEG) 분석 결과 59
5. 정량화뇌파(QEEG)와 24시간 Holter Monitoring의 HRV간 상관 관계 84
라. 고찰 및 결론 134
제2장 한의 빅데이터 기반 Heart-Mind 평가 모델개발 143
Ⅰ. 한의 빅데이터 기반 심주신지 모델 개발 143
1. 선행연구 기반 심혈관 정량지표 후보변수 탐색 143
Ⅱ. 심주신지 평가모델 예비검정 146
1. KDC 코호트 자료를 활용한 심장 관련 변수들의 상관성 분석 146
2. 정신관련 (미병, PWI, 수면) 그룹별 심장평가 변수의 차이: 단면분석 149
3. 대전대 visit1-visit3 간 변화(호전/악화)에 따른 심혈관 지표 차이 검정: 경시적 분석 156
4. 한의변증(한열)에 따른 sub-group 분석 161
5. 중재연구 데이터와의 연계성 162
[별첨 1] HRV 주요변수별 4분위 그룹에 따른 정신평가 점수 차이 검정 165
[별첨 2] 변증(한열)유형에 따른 심장평가변수 탐색 179
[부록] 연구데이터 관리계획 187
참고문헌 188
제1장 명상기반 정량화 뇌파와 24시간 심전도를 이용한 심-뇌 상관성 분석을 위한 임상연구 모델구축 11
Ⅰ. 연구 대상인 '심(心)'에 대한 명확한 인식론 확립 11
표 1. 심의 6가지 분류 11
표 2. 심장으로서 심 11
표 3. 마음 혹은 정신으로서 심 12
표 4. 마음 혹은 정신으로서 심 12
표 5. Heart as One of Five Elements 13
표 6. Meridian으로서 심 14
표 7. '심'이 포함된 복합어 15
Ⅱ. 예비적 임상연구: 정량화 뇌파와 24시간 활동심전도의 상관성 연구를 위한 명상기반 예비적 임상연구 20
Table 1. 임상시험 연구 진행표 20
Table 2. 연구대상자의 특징 25
Table 3. Screening 유효검사 빈도 26
Table 4. Screening 유효검사 하위 군 분류 26
Table 5. Statistical Change of main-test result 28
Table 6. 명상 기반 프로그램 전 후 24시간 Holter Mornitoring의 변화 30
Table 7. 2단계(RM중)과 4단계(SM중) absolute power 비교 33
Table 8. 2단계(RM중)과 4단계(SM중) Relative power 비교 34
Ⅲ. 본 임상연구 수행: 정량화 뇌파와 24시간 활동심전도의 상관성 연구를 위한 명상기반 임상연구 51
Table 1. Demographic Descriptive Statistics 51
Table 2/Table 3. Paired t-test of RM group about questionnaires between pre and post meditation 53
Table 3/Table 4. Paired t-test of SM group about questionnaires between pre and post meditation 54
Table 4/Table 5. Independent t-test about questionnaires between RM and SM group 55
Table 5/Table 6. Paired t-test of RM group about components of HRV measured by 24-h holter monitoring 57
Table 6/Table 7. Paired t-test of SM group about components of HRV measured by 24-h holter monitoring 58
Table 7/Table 8. Paired t-test of Absolute Power(uV Sq) using Linked Ear Montage between pre and post meditation at RM group (Eye closed state) 60
Table 8/Table 9. Paired t-test of Absolute Power(uV Sq) using Linked Ear Montage between pre and post meditation at SM group (Eye closed state) 63
Table 9/Table 10. Paired t-test of Relative Power(uV Sq) using Linked Ear Montage between pre and post meditation at RM group (Eye closed state) 66
Table 10/Table 11. Paired t-test of Relative Power(uV Sq) using Linked Ear Montage between pre and post meditation at SM group (Eye closed state) 69
Table 11/Table 12. Difference of absolute power(uV Sq) using linked ear montage between pre and post RM (Eye closed state) 72
Table 12/Table 13. Difference of absolute power(uV Sq) using linked ear montage between pre and post SM (Eye closed state) 74
Table 13/Table 14. Difference of relative power(uV Sq) using linked ear montage between pre and post RM (Eye closed state) 77
Table 14/Table 15. Difference of relative power(uV Sq) using linked ear montage between pre and post SM (Eye closed state) 79
Table 15/Table 16. RM군 , SM군 눈감은 상태에서의 Alpha1의 absolute power 집단 간의 변화 82
Table 16/Table 17. RM군 , SM군 눈감은 상태에서의 Alpha2의 relative power 집단 간의 변화 83
Table 17/Table 18. The results of correlation analysis between HRV of 24-h holter monitoring and Delta absolute power of QEEG in RM group(pre meditation, step1) 85
Table 18/Table 19. The results of correlation analysis between HRV of 24-h holter monitoing and Delta absolute power of QEEG in SM group(pre meditation, step1) 86
Table 19/Table 20. The results of correlation analysis between HRV of 24-h holter monitoing and Delta relative power of QEEG in RM group(pre meditation, step1) 87
Table 20/Table 21. The results of correlation analysis between HRV of 24-h holter monitoing and Delta relative power of QEEG in SM group(pre meditation, step1) 88
Table 21/Table 22. The results of correlation analysis between HRV of 24-h holter monitoing and Delta absolute power of QEEG in RM group(being meditation, step2) 89
Table 22/Table 23. The results of correlation analysis between HRV of 24-h holter monitoing and Delta absolute power of QEEG in SM group(being meditation, step2) 90
Table 23/Table 24. The results of correlation analysis between HRV of 24-h holter monitoing and Delta relative power of QEEG in RM group(being meditation, step2) 91
Table 24/Table 25. The results of correlation analysis between HRV of 24-h holter monitoing and Delta absolute power of QEEG in SM group(being meditation, step2) 92
Table 25/Table 26. The results of correlation analysis between HRV of 24-h holter monitoing and Delta absolute power of QEEG in RM group(post meditation, step3) 93
Table 26/Table 27. The results of correlation analysis between HRV of 24-h holter monitoing and Delta absolute power of QEEG in SM group(post meditation, step3) 94
Table 27/Table 28. The results of correlation analysis between HRV of 24-h holter monitoing and Delta relative power of QEEG in RM group(post meditation, step3) 95
Table 28/Table 29. The results of correlation analysis between HRV of 24-h holter monitoing and Delta relative power of QEEG in SM group(post meditation, step3) 96
Table 29/Table 30. The results of correlation analysis between HRV of 24-h holter monitoring and Theta absolute power of QEEG in RM group(pre meditation, step1) 97
Table 30/Table 31. The results of correlation analysis between HRV of 24-h holter monitoing and Theta absolute power of QEEG in SM group(pre meditation, step1) 98
Table 31/Table 32. The results of correlation analysis between HRV of 24-h holter monitoing and Theta relative power of QEEG in RM group(pre meditation, step1) 99
Table 32/Table 33. The results of correlation analysis between HRV of 24-h holter monitoing and Theta relative power of QEEG in SM group(pre meditation, step1) 101
Table 33/Table 34. The results of correlation analysis between HRV of 24-h holter monitoing and Theta absolute power of QEEG in RM group(being meditation, step2) 102
Table 34/Table 35. The results of correlation analysis between HRV of 24-h holter monitoing and Theta absolute power of QEEG in SM group(being meditation, step2) 103
Table 35/Table 36. The results of correlation analysis between HRV of 24-h holter monitoing and Theta relative power of QEEG in RM group(being meditation, step2) 104
Table 36/Table 37. The results of correlation analysis between HRV of 24-h holter monitoing and Theta absolute power of QEEG in SM group(being meditation, step2) 105
Table 37/Table 38. The results of correlation analysis between HRV of 24-h holter monitoing and Theta absolute power of QEEG in RM group(post meditation, step3) 106
Table 38/Table 39. The results of correlation analysis between HRV of 24-h holter monitoing and Theta absolute power of QEEG in SM group(post meditation, step3) 107
Table 39/Table 40. The results of correlation analysis between HRV of 24-h holter monitoing and Theta relative power of QEEG in RM group(post meditation, step3) 108
Table 40/Table 41. The results of correlation analysis between HRV of 24-h holter monitoing and Theta relative power of QEEG in SM group(post meditation, step3) 109
Table 41/Table 42. The results of correlation analysis between HRV of 24-h holter monitoring and Alpha absolute power of QEEG in RM group(pre meditation, step1) 110
Table 42/Table 43. The results of correlation analysis between HRV of 24-h holter monitoing and Alpha absolute power of QEEG in SM group(pre meditation, step1) 111
Table 43/Table 44. The results of correlation analysis between HRV of 24-h holter monitoing and Alpha relative power of QEEG in RM group(pre meditation, step1) 112
Table 44/Table 45. The results of correlation analysis between HRV of 24-h holter monitoing and Alpha relative power of QEEG in SM group(pre meditation, step1) 113
Table 45/Table 46. The results of correlation analysis between HRV of 24-h holter monitoing and Alpha absolute power of QEEG in RM group(being meditation, step2) 114
Table 46/Table 47. The results of correlation analysis between HRV of 24-h holter monitoing and Alpha absolute power of QEEG in SM group(being meditation, step2) 115
Table 47/Table 48. The results of correlation analysis between HRV of 24-h holter monitoing and Alpha relative power of QEEG in RM group(being meditation, step2) 116
Table 48/Table 49. The results of correlation analysis between HRV of 24-h holter monitoing and Alpha absolute power of QEEG in SM group(being meditation, step2) 117
Table 49/Table 50. The results of correlation analysis between HRV of 24-h holter monitoing and Alpha absolute power of QEEG in RM group(post meditation, step3) 118
Table 50/Table 51. The results of correlation analysis between HRV of 24-h holter monitoing and Alpha absolute power of QEEG in SM group(post meditation, step3) 119
Table 51/Table 52. The results of correlation analysis between HRV of 24-h holter monitoing and Alpha relative power of QEEG in RM group(post meditation, step3) 120
Table 52/Table 54. The results of correlation analysis between HRV of 24-h holter monitoing and Alpha relative power of QEEG in SM group(post meditation, step3) 121
Table 53/Table 55. The results of correlation analysis between HRV of 24-h holter monitoring and Beta absolute power of QEEG in RM group(pre meditation, step1) 122
Table 54/Table 56. The results of correlation analysis between HRV of 24-h holter monitoing and Beta absolute power of QEEG in SM group(pre meditation, step1) 123
Table 55/Table 57. The results of correlation analysis between HRV of 24-h holter monitoing and Beta relative power of QEEG in RM group(pre meditation, step1) 124
Table 56/Table 58. The results of correlation analysis between HRV of 24-h holter monitoing and Beta relative power of QEEG in SM group(pre meditation, step1) 125
Table 57/Table 59. The results of correlation analysis between HRV of 24-h holter monitoing and Beta absolute power of QEEG in RM group(being meditation, step2) 126
Table 58/Table 60. The results of correlation analysis between HRV of 24-h holter monitoing and Beta absolute power of QEEG in SM group(being meditation, step2) 127
Table 59/Table 61. The results of correlation analysis between HRV of 24-h holter monitoing and Beta relative power of QEEG in RM group(being meditation, step2) 128
Table 60/Table 62. The results of correlation analysis between HRV of 24-h holter monitoing and Beta absolute power of QEEG in SM group(being meditation, step2) 129
Table 61/Table 63. The results of correlation analysis between HRV of 24-h holter monitoing and Beta absolute power of QEEG in RM group(post meditation, step3) 130
Table 62/Table 64. The results of correlation analysis between HRV of 24-h holter monitoing and Beta absolute power of QEEG in SM group(post meditation, step3) 131
Table 63/Table 65. The results of correlation analysis between HRV of 24-h holter monitoing and Beta relative power of QEEG in RM group(post meditation, step3) 132
Table 64/Table 66. The results of correlation analysis between HRV of 24-h holter monitoing and Beta relative power of QEEG in SM group(post meditation, step3) 133
제2장 한의 빅데이터 기반 Heart-Mind 평가 모델개발 144
표 1. HRV를 활용하여 건강을 평가한 주요 선행연구 144
표 2. 인구학적 정보 146
표 3. 미병 그룹 간 심장평가 변수들의 차이 149
표 4. PWI 그룹 간 심장평가 변수들의 차이 152
표 5. PSQI 그룹 간 심장평가 변수들의 차이 154
표 6. PSQI 변화 그룹에 따른 심혈관 변수 차이 157
표 7. PWI 변화 그룹에 따른 심혈관 변수 차이 159
Fig. 1. 연구 진행과정 20
Fig. 2. The Sub-Factors of FFMQ-S, K-PANAS, CESI Change's mean 29
Fig. 3. 명상 기반 프로그램 전 후 24시간 Holter Mornitoring의 변화 31
Fig. 4. Absolute power independent t-Test(2-4 Step) 32
Fig. 5. Relative power independent t-Test(2-4 Step) 32
Fig. 6. Coherence Independent (t-Test(2-4 Step) 32
Ⅲ. 본 임상연구 수행: 정량화 뇌파와 24시간 활동심전도의 상관성 연구를 위한 명상기반 임상연구 37
Fig. 1. Summary of clinical trial design 37
Fig. 2. Procedure of this study 38
Fig. 3. Script of resource mindfulness 47
Fig. 4. Script of resource mindfulness 48
Fig. 5. Study flow chart 50
Fig. 6. Brain Mapping of Distribution and the result of paired t-test of Absolute Power(uV Sq) using Linked Ear Montage between pre and post meditation at RM group (Eye closed state) 61
Fig. 7. Brain Mapping of Distribution and the result of paired t-test of Absolute Power(uV Sq) using Linked Ear Montage between pre and post meditation at SM group (Eye closed state) 64
Fig. 8. Brain Mapping of Distribution and the result of paired t-test of Relative Power(uV Sq) using Linked Ear Montage between pre and post meditation at RM group (Eye closed state) 67
Fig. 9. Brain Mapping of Distribution and the result of paired t-test of Relative Power(uV Sq) using Linked Ear Montage between pre and post meditation at SM group (Eye closed state) 70
Fig. 10. Brain Mapping of Difference of absolute power(uV Sq) of Alpha, Alpha1, Alpha2 wave between pre and post RM 73
Fig. 11. Brain Mapping of Difference of absolute power(uV Sq) of Alpha, Alpha1, Alpha2 wave between pre and post SM 75
Fig. 12. Brain Mapping of Difference of relative power(uV Sq) of Alpha, Alpha1, Alpha2 wave between pre and post RM 78
Fig. 13. Brain Mapping of Difference of relative power(uV Sq) of Alpha, Alpha1, Alpha2 wave between pre and post SM 80
Fig. 14. Brain Mapping of Paired t-test of FFT coherence of Alpha band between pre and post meditation 81
별첨표목차
Table 1. 삶의 질에 따른 분류 시 인구학적 특성 179
Table 2. 삶의 질 호전/악화 그룹간 기기 및 설문지표 차이 (한증/비한증) 180
Table 3. 삶의 질 호전/악화 그룹간 기기 및 설문지표 차이 (열증/비열증) 182
Table 4. 피로(CFS)에 따른 분류 시 인구학적 특성 184
Table 5. 피로 호전/악화 그룹간 기기 및 설문지표 차이 (비한증/한증) 185
Table 6. 피로 호전/악화 그룹간 기기 및 설문지표 차이 (비열증/열증) 186