Contents
About Public Health England 2
Executive Summary 4
1. Background 5
2. Objectives 6
3. Definition of a confirmed case of IMD 6
3.1. Men A/C/W/Y IMD 6
3.2. MenB IMD 7
3.2.1. A confirmed case of MATS positive MenB IMD case is defined as: 7
3.2.2. A non-MenB MATS positive confirmed case of IMD is defined as: 7
4. Enhanced Surveillance for meningococcal disease 8
4.1. Existing national surveillance activities 8
4.2. Routine laboratory investigation of IMD at MRU 8
4.3. Neisseria meningitidis isolate characterisation 8
4.3.1. Phenotypic characterisation 8
4.3.2. Genotypic characterisation 8
4.4. Antibiotic susceptibility testing 9
4.5. Acute and Convalescent serum samples 9
4.6. Optimum clinical specimens for suspected meningococcal disease 9
5. National surveillance database 10
6. Follow up procedures 10
6.1. SUSPECTED IMD CASES reported to HPTs 12
6.2. CONFIRMED CASES reported to PHE Colindale 12
7. Possible future considerations for further investigations 13
8. Measurement of vaccine coverage 13
9. Calculation of vaccine effectiveness 14
10. Dissemination of information and outputs 14
11. References 15
Appendix 1. Surveillance questionnaire(Form MENSV01, August 2015) 17
Appendix 2. PHE Letters 20
Appendix 3. Sample submission form 24
Appendix 4. Clinical questionnaire(Form MENSV02, August 2015) 26
FIGURE 1. Overview of laboratory surveillance processes 16