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Danggui is one of the most popular herbal medicines consumed by patients in different clinical settings in Asian countries. In this study, the two major pyranocoumarin compounds extracted from the Korean Angelica gigas root decursin (DC) and decursinol angelate (DA) were examined in vitro with regard to their abilities to inhibit hepatic CYP1A1/2, CYP2D15, and CYP3A12 catalytic activities in canine liver microsomes. The two components were capable of inhibiting CYP1A1/2, CYP2D15, and CYP3A12 catalytic activities, but the potencies varied. DC and DA selectively and noncompetitively inhibited CYP1A1/2 activity, with Ki values of 90.176 and 67.560 μM, respectively. On the other hand, they exhibited slight inhibitory effects on CYP2D15 and CYP3A12 with Ki values of 666.180 and 872.502 μM, 990.500 and 909.120 μM (1’hydroxymidazolam, MDZ1’H), and 802.800 and 853.920 μM (4- hydroxymidazolam, MDZ4H), respectively. Additionally, they showed increased inhibition after preincubation, which suggests the involvement of a mechanism-based inhibition. In sum, this in vitro data should be heeded as a signal of possible in vivo interactions. The use of human liver preparations would considerably strengthen the practical impact of the data generated from this study.

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A new abietane diterpenoid from Isodon inflexus Chul Lee ;Seong Su Hong ;Xiang Hua Han ;Qinghao Jin ;Dayu Li ;Tae Ook Kim ;Hyun-kyu Kim ;Jeongrai Le pp.1381-1384

Enhancement of the immune responses of mice to Bacillus anthracis protective antigen by CIA07 combined with alum Su Hee Kim ;Shin Ae Park ;Hye Kyeong Kim ;Yang Je Cho ;Kwang Sung Kim ;Yeon Hee Kim ;Jeong Hoon Chun pp.1385-1392

One-pot conversion of trimethylsilyl ethers into urethanes using chlorosulfonyl isocyanate :application to the synthesis of a novel neuromodulator carisbamate Guang Ri Dong ;Qing Ri Li ;Seol Hee Woo ;In Su Kim ;Young Hoon Jung pp.1393-1398

Apoptosis-inducing effect of akebia saponin D from the roots of Dipsacus asper wall in U937 cells Seung-il Jeong ;Beng Zhou ;Jin-beom Bae ;Nam-seok Kim ;Sun-geun Kim ;Jin Kwon ;Dae-keun Kim ;Tae-yon pp.1399-1404

Inhibitory activities of the alkaloids from coptidis rhizoma against aldose reductase Hyun Ah Jung ;Na Young Yoon ;Hyun Ju Bae ;Byung-sun Min ;Jae Sue Choi pp.1405-1412

Topoisomerase Ⅰ and Ⅱ inhibitory constituents from the bark of Tilia amurensis Jae-young Choi ;Chang-seob Seo ;Ming-shan Zheng ;Chong-soon Lee ;Jong-keun Son pp.1413-1418

Bavachin and isobavachalcone, acyl-coenzyme A: cholesterol acyltransferase inhibitors from Psoralea corylifolia Jung Ho Choi ;Mun-chual Rho ;Seung Woong Lee ;Ji Na Choi ;Koanhoi Kim ;Gyu Young Song ;Young Kook Ki pp.1419-1423

In vitro inhibitory potential of decursin and decursinol angelate on the catalytic activity of cytochrome P-450 1A1/2, 2D15, and 3A12 isoforms in canine hepatic microsomes A. M. Abd El-Aty ;Syed Sher Shah ;Bo-mee Kim ;Jeong-heui Choi ;Hee-jung Cho ;Hee-Yi ;Byung-joon Chan pp.1425-1435

Signaling mechanisms of sphingosine 1-phosphate-induced ERK1/2 activation in cultured feline esophageal smooth muscle cells Fa Yong Chung ;Hyun Ju Song ;Sun Young Park ;Hyeon Soo Jang ;Dong-seok Kim ;Sang Soo Sim ;Uy Dong So pp.1437-1445

Tectorigenin inhibits IFN-γ/LPS-induced inflammatory responses in murine macrophage RAW 264.7 cells Cheol-ho Pan ;Eun Sun Kim ;Sang Hoon Jung ;Chu Won Nho ;Jae Kwon Lee pp.1447-1456

Neuroprotective effects of chronic hesperetin administration in mice Eun Jeong Choi ;Woong Shick Ahn pp.1457-1462

Cytotoxicity of amphotericin B-incorporated polymeric micelles composed of poly(DL-lactide-co-glycolide)/dextran graft copolymer Je-yong Bang ;Chae-eun Song ;Chan Kim ;Woo-dae Park ;Ki-rae Cho ;Pyoung-il Kim ;Sang-rak Lee ;Wan-ta pp.1463-1469

Expression of thymosin α1-thymopentin fusion peptide in Pichia pastoris and its characterization Demin Gao ;Xulong Zhang ;Jian Zhang ;Jichao Cao ;Fengshan Wang pp.1471-1476

New phenylpropanoid esters of sucrose from Polygonum hydropiper and their antioxidant activity Phan Van Kiem ;Nguyen Xuan Nhiem ;Nguyen Xuan Cuong ;Tran Quynh Hoa ;Hoang Thanh Huong ;Le Mai Huong pp.1477-1482

Compound K suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair in human keratinocytes Bao-xiang Cai ;Dan Luo ;Xiang-fei Lin ;Jie Gao pp.1483-1488

Antidiabetic activity of angelan isolated from Angelica gigas NaKai Hwan Mook Kim ;Jong Soon Kang ;Song-kyu Park ;Kiho Lee ;Jee Youn Kim ;Yeon Jin Kim ;Jin Tae Hong ;Yo pp.1489-1496

Enhanced dissolution of ibuprofen using solid dispersion with poloxamer 407 Madhuri Newa ;Krishna Hari Bhandari ;Dong Hoon Oh ;Young Ran Kim ;Joon Ho Sung ;Jung Oh Kim ;Jong So pp.1497-1507

Microencapsulation of antibiotic rifampicin in poly(3-hydroxybutyrate-co-3-hydroxyvalerate) N. Durán ;M.A. Alvarenga ;E.C. Da Silva ;P.S. Melo ;P.D. Marcato pp.1509-1516

The effects of ketorolac tromethamine and baicalein on the levels of inflammatory factors in human synoviocytes Jae-heon Yang ;Mi-young Yun ;Nam-hee Lee ;Dae-keun Kim ;Young-il Kim ;Young-hee Noh ;Tae-youl Kim ;S pp.1517-1523

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