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22대 대한민국 국회 국회정보길라잡이 국회의원검색
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소장정보 검색

국회도서관 홈으로 정보검색 소장정보 검색
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약어 목록 6

Abstract 7

I. 서론 9

II. 연구대상 및 방법 11

1. 연구대상 11

2. 연구방법 11

1) 심초음파도 검사 11

2) GBP(Gated blood pool) 스캔 12

3. 통계적 방법 12

III. 결과 15

IV. 고찰 26

V. 결론 29

참고문헌 30

표목차

Table 1. Clinical characteristics of patients 16

Table 2. Baseline echocardiographic parameters 17

Table 3. Echocardiographic parameters after follow-up 18

Table 4. GBP scan parameters after follow-up 22

그림목차

Figure 1. Schematic diagram of M-mode of the left ventricle. 13

Figure 2. Protocols of dobutamine gated blood pool scan... 14

Figure 3. Changes of echocardiogrphic parameters... 19

Figure 4. Changes of echocardiogrphic parameters... 20

Figure 5. Changes of EF_GBP by dobutamine stress 23

Figure 6. Changes of △EF_GBP/EF_GBP rest at follow-up 24

Figure 7. Correlation between △EF_Echo and △EF_GBP 25

초록보기

Background: The prognosis of patients with DCMP(dilated cardiomyopathy) is variable. The predictive value of currently utilized tests is suboptimal. The purpose of this study is to examine the prognostic value of dobutamine GBP(Gated blood pool) scan and to evaluate the functional reserve in the DCMP.

Methods: Twenty patients (10 men, 10 women) with diagnosed as DCMP underwent echocardiography and GBP scan. Left ventricular ejection fraction (LVEF) before and after low dose dobutamine infusion (10μg/kg/min) were determined by GBP scan. A follow-up echocardiographic assessment was done at 9.4 months after initial evaluation.

Results: Patients were divided into two groups based on ΔEF 7% on echocardiography. Baseline echocardiographic parametes were as follows; EF(41.26±8.02% vs 36.04±12.5%), LVESD(47.25 ±11.14 vs 51.8±7.9mm), LV mass( 276.27±98.55g vs 331.1±122.7g), LVMI( 183.88±61.1g/㎡ vs 208.11±74.55g/㎡). Follow-up echocardiographic parametes were as follows; EF(40.75±7.36% vs 53.46±10.02%), LVESD(48.51±7.51 vs 43.73±7.83mm), LV mass(244.67±66.91g vs 259.02±79.73g) and LVMI(167.68±53.58g/㎡ vs 164.405±51.20g/㎡ ). EF_GBP rest was 39±17.91% vs 36±15.37%. EF_GBP dobu was 42±16.56% vs 41±14.7%. ΔEF≥7% group was significant increased in ΔEF_GBP(3±2.33% vs 5±3.47%)(p ＝0.02) and ΔEF_GBP/EF_GBP rest(0.12±0.10 vs 0.16±0.14)(p＝0.038).

Conclusion: This study demonstrates that dobutamine GBP scan may predict the improvement or deterioration of cardiac function in DCMP. Dobutamine GBP scan may be used as a simple and valuable diagnostic method to evaluate the myocardial functional reserve in DCMP patients.

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