본문 바로가기 주메뉴 바로가기
22대 대한민국 국회 국회정보길라잡이 국회의원검색
회원가입 로그인
HOME

정보검색

소장정보 검색

국회도서관 홈으로 정보검색 소장정보 검색
결과 내 검색 동의어 포함
결과 내 검색 동의어 포함

-

목차보기

title page

Contents

(Abstract) 5

Introduction 7

Materials and methods 9

Materials 9

Degradation of HA 9

Preparation of cisplatin-incorporated nanoparticles of HA 10

Measurement of the drug contents and loading efficiency of nanoparticles of HA 10

Measurement by gel permeation chromatography(GPC) 11

Transmission electron microscopy (TEM) observation 11

Particle size and zeta potential measurement 11

X-ray powder diffractometry (XRD) measurement 12

Drug release study 12

Hyaluronidase extraction from tumor cell lines 12

Zymography of hyaluronic acid 13

Results 15

Characterization of degraded HA 15

Preparation of cisplatin-incorporated nanoparticles 15

Cisplatin release from nanoparticles 16

Discussion 18

Conclusion 20

References 21

〈초록〉 36

List of Table

Table1. Characterization of cisplatin-incorporated HA nanoparticles 28

List of Figure

Fig. 1. Schematic illustrations of nanoparticle formation by ion complex between HA and cisplatin. Cisplatin incorporated HA nanoparticles are formed by ion complex between carboxyl groups... 29

Fig. 2. GPC chromatogram of degraded HA. the GPC system was composed of a waters 515 HPLC pump, waters 410 differential refractometer, waters 486 tunable absorbance detector,... 30

Fig. 3. Particle size distribution against drug contents. A sample solution prepared by the dialysis method was used for the particle size measurement (concentration: 0.1 w/v). 31

Fig. 4. Morphology of cisplatin-incorporated HA nanoparticles (100/10 of table 1 ) observed by TEM. A drop of nanoparticle suspension was placed onto a carbon film coated on a copper grid for TEM... 32

Fig. 5. XRD patterns of cisplatin-incorporated polymeric micelle of HAgPEG. cisplatin (a), HA (b), cisplatin-incorporated nanoparticles(100/5 in table 1) (c), cisplatin-incorporated nanoparticles (100/10) ... 33

Fig. 6. The effect of drug contents (a) and presence of hyaluronidase (b) on the cisplatin release from HA nanoparticles. the hyaluronidase (100 units/ml ) was added to the dialysis tube containing... 34

Fig.7. HA zymography using U343MG and U87MG cell lines (a). the effect of extracted hyaluronidase from U343MG and U87MG cell lines (b). the hyaluronidase activity was determined in the form... 35

추천서가 (다양한 추천 자료를 만나보세요)

권호기사보기

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 기사목차