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22대 대한민국 국회 국회정보길라잡이 국회의원검색
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정보검색

소장정보 검색

국회도서관 홈으로 정보검색 소장정보 검색
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국문초록

Contents

Introduction 7

Materials and methods 9

1. Study design 9

2. Isolation and primary culture of ADSCs 11

3. Induction of AMI and cell transplantation 11

4. Cardiac function measurement 12

5. Histopathology and immunohistochemistry 13

6. Statistical analysis 14

Results 15

1. Cell culture of ADSCs 15

2. Assessment of cardiac function 16

3. Histopathological studies of ADSCs transplatation 22

4. Immunohistological studies of ADSCs transplantation 22

Discussion 26

REFERENCES 30

Abstract 35

List of Tables

Table 1. Results of echocardiographic analyses 17

Table 2. Comparison of echocardiographic data in study mice 18

List of Figures

Figure 1. Study design (see text for details): MI = myocardial infarction; HBSS = Hank's balanced salt solution Echo = echocardiography; ADSCs = adipose tissue-derived stromal cells. 10

Figure 2. Typical images of cultured ADSCs. This panel showed phase contrast images of cultured ADSCs under optical microscope at 7 days. Cultured ADSCs have fibroblast-like morphology and can be... 15

Figure 3. Change of cardiac functional parameters: The LVEF and FS (%) in cell transplant group were significantly greater than those in control group (p=0.0023 and p=0.006). 19

Figure 4. Change of left ventricle dimensions: LVEDD in ADSCs transplant (control) to 4.14±0.53 mm (ADSCs), but there was no statistical difference... 20

Figure 5. Assessment of cardiac function in mice. The FS in cells transplanted group was significantly better than that in control group (p=0.006). The LVEF improved in cells transplanted group at 2 weeks to compare with control group... 21

Figure 6. Masson' s trichrome staining of ischemic hearts. Significant differences between ADSCs transplant group and control group in injury size, infarct area, wall thickness or scar formation at 2 weeks after myocardial... 23

Figure 7. Migration of transplanted ADSCs into infarct zone. Red fluorescence (B, D) indicate ADSCs labeled with cell tracker CM-Dil. Transplanted ADSCs was found to be migrated into the injured site and integrated into the scar area. 24

Figure 8. Immunohistochemistry of endothelial cells: Immunolabeling for the endothelial cell marker vWF showed the presence of endothelial cells in the range of blood vessel sizes from large arteries to small capillaries (white... 25

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