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제1장 서론 10

제2장 이론 12

2.1. 눈의 구조 12

2.2. 백내장 14

2.2.1. 백내장의 정의 14

2.2.2. 백내장의 역사 14

2.2.3. 백내장의 종류 16

2.3. 인공수정체 18

2.3.1. 인공수정체 정의 18

2.3.2. 인공수정체 역사 18

2.3.3. 인공수정체 분류 21

2.3.4. 인공수정체의 재질 22

2.3.5. 인공수정체의 제조 23

제3장 실험 25

3.1. 시약 및 재료 25

3.2. 실험 방법 28

3.3. 분석 방법 30

3.3.1. 투과율 30

3.3.2. 접촉각 31

3.3.3. 평형함수율 32

3.3.4. 굴절률 32

3.3.5. 시차주사열량분석 33

3.3.6. 반짝임 변성 33

제4장 결과 및 고찰 34

4.1. 투과율 34

4.2. 접촉각 39

4.3. 평형함수율 44

4.4. 굴절률 49

4.5. 시차주사열량분석 54

4.6. 반짝임 변성 59

제5장 결론 68

참고문헌 70

ABSTRACT 75

Table 1. Classification according to different shapes of IOL 21

Table 2. Chemical Structure of Materials used in this work 26

Table 3. Experimental condition for preparation of hydrophobic acrylic... 27

Figure 1. Anatomy of Eye. 13

Figure 2. Types of cataracts. A: Nuclear cataract. B: PSC... 17

Figure 3. Timeline showing the six major generations of IOL. 20

Figure 4. Manufacturing method of Intraocular lens. A: Casting... 24

Figure 5. Flow chart for preparation of IOL. 29

Figure 6. Measurement of Transmittance. 30

Figure 7. Measurement of Contact Angle using sessile drop method. 31

Figure 8. Transmittance of hydrophobic acrylic IOL prepared with... 35

Figure 9. Transmittance of hydrophobic acrylic IOL prepared with... 36

Figure 10. Transmittance of hydrophobic acrylic IOL prepared with... 37

Figure 11. Transmittance of hydrophobic acrylic IOL prepared with... 38

Figure 12. Water Contact Angle of hydrophobic acrylic IOL prepared... 40

Figure 13. Water Contact Angle of hydrophobic acrylic IOL prepared... 41

Figure 14. Water Contact Angle of hydrophobic acrylic IOL prepared... 42

Figure 15. Water Contact Angle of hydrophobic acrylic IOL prepared... 43

Figure 16. Equilibrium Water Content of hydrophobic acrylic IOL... 45

Figure 17. Equilibrium Water Content of hydrophobic acrylic IOL... 46

Figure 18. Equilibrium Water Content of hydrophobic acrylic IOL... 47

Figure 19. Equilibrium Water Content of hydrophobic acrylic IOL... 48

Figure 20. Refractive Index of hydrophobic acrylic IOL prepared with... 50

Figure 21. Refractive Index of hydrophobic acrylic IOL prepared with... 51

Figure 22. Refractive Index of hydrophobic acrylic IOL prepared with... 52

Figure 23. Refractive Index of hydrophobic acrylic IOL prepared with... 53

Figure 24. DSC curve of hydrophobic acrylic IOL prepared with... 55

Figure 25. DSC curve of hydrophobic acrylic IOL prepared with... 56

Figure 26. DSC curve of hydrophobic acrylic IOL prepared with... 57

Figure 27. DSC curve of hydrophobic acrylic IOL prepared with... 58

Figure 28. Optical microscopy images of hydrophobic acrylic... 60

Figure 29. Glistening Number of hydrophobic acrylic IOL prepared with... 61

Figure 30. Optical microscopy images of hydrophobic acrylic... 62

Figure 31. Glistening Number of hydrophobic acrylic IOL prepared with... 63

Figure 32. Optical microscopy images of hydrophobic acrylic... 64

Figure 33. Glistening Number of hydrophobic acrylic IOL prepared with... 65

Figure 34. Optical microscopy images of hydrophobic acrylic... 66

Figure 35. Glistening Number of hydrophobic acrylic IOL prepared with... 67

초록보기

 In the present study, we copolymerized hydrophilic and hydrophobic monomers to produce hydrophobic acrylic intraocular lenses with reduced glistening. The effect of the type and content of hydrophilic monomer on the hydrophobic acrylic intraocular lens was confirmed. The Hydrophobic monomers were 2-phenoxyethyl acrylate (POEA). The hydrophilic monomers were 2-Hydroxyethyl acrylate (HEA), Hydroxypropyl acrylate (HPA), 4-Hydroxybutyl acrylate (HBA), and 2-Hydroxyethyl methacrylate (HEMA). In addition, hydrophobic acrylic intraocular lenses were prepared by casting molding using ethylene glycol dimethacrylate (EGDMA) and azobisisobutyronitrile (AIBN) as cross-linking agents and thermal initiators, respectively. Transmittance, contact angle, equilibrium water content, refractive index, the glistening, and glass transition temperature were measured to confirm the change in physical properties of the sample according to the addition of the hydrophilic monomer.

1. Transmittance of all samples showed a transmittance of 90% or more, and the addition of hydrophilic monomer did not have an effect on the transmittance. As the amount of hydrophilic monomer is increased, the contact angle and water content tend to increase. This seems to be due to the increased hydrophilicity by the hydrophilic monomer. The refractive index tended to decrease with increasing water content with a relatively low refractive index.

2. Glistening tended to decrease as the amount of hydrophilic monomer was increased. This is because the hydroxyl group induces hydrogen bonding between polymer and the water molecule so that the water molecules do not gather between the polymer structures and diffuses.

3. As a result of measuring the glass transition temperature, it was confirmed that the hydrophobic monomer and the hydrophilic monomer were copolymerized by showing one glass transition temperature value. As the amount of HEA, HPA, and HEMA is increased, the glass transition temperature shows to increase. but the addition of HBA reduces the glass transition temperature. The glass transition temperatures of all samples were lower than room temperature.

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